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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共22条记录   The ubiquitin clan: A protein family essential for life Preface [作者：Wolf, DH,期刊：FEBS Letters, 页码：2769-2771 , 文章类型： Editorial Material，,卷期：2011年585-18] Ubiquitin-family modifications in the replication of DNA damage [作者：Lehmann, AR,期刊：FEBS Letters, 页码：2772-2779 , 文章类型： Review，,卷期：2011年585-18] The cell uses specialised Y-family DNA polymerases or damage avoidance mechanisms to replicate past damaged sites in DNA. These processes are under complex regulatory systems, which employ different types of post-transla... Dynamic regulation of PCNA ubiquitylation/deubiquitylation [作者：Fox, JT; Lee, KY; Myung, K,期刊：FEBS Letters, 页码：2780-2785 , 文章类型： Review，,卷期：2011年585-18] Proliferating Cell Nuclear Antigen (PCNA) ubiquitylation plays a crucial role in maintaining genomic stability during DNA replication. DNA damage stalling the DNA replication fork induces PCNA ubiquitylation that activat... Roles of sequential ubiquitination of PCNA in DNA-damage tolerance [作者：Zhang, WW; Qin, ZSA; Zhang, XJ; Xiao, W,期刊：FEBS Letters, 页码：2786-2794 , 文章类型： Review，,卷期：2011年585-18] Living organisms not only repair DNA damage induced by environmental agents and endogenous cellular metabolites, but have also developed mechanisms to survive in the presence of otherwise lethal lesions. DNA-damage toler... RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response [作者：Shiloh, Y; Shema, E; Moyal, L; Oren, M,期刊：FEBS Letters, 页码：2795-2802 , 文章类型： Review，,卷期：2011年585-18] The DNA damage response (DDR) is emerging as a vast signaling network that temporarily modulates numerous aspects of cellular metabolism in the face of DNA lesions, especially critical ones such as the double strand brea... p53 regulation by ubiquitin [作者：Brooks, CL; Gu, W,期刊：FEBS Letters, 页码：2803-2809 , 文章类型： Review，,卷期：2011年585-18] The ubiquitination pathway is a highly dynamic and coordinated process that regulates degradation as well as numerous processes of proteins within a cell. The p53 tumor suppressor and several factors in the pathway are r... Ubiquitin family modifications and template switching [作者：Branzei, D,期刊：FEBS Letters, 页码：2810-2817 , 文章类型： Review，,卷期：2011年585-18] Homologous recombination plays an important role in the maintenance of genome integrity. Arrested forks and DNA lesions trigger strand annealing events, called template switching, which can provide for accurate damage by... Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best! [作者：Scrima, A; Fischer, ES; Lingaraju, GM; Bohm, K; Cavadini, S; Thoma, NH,期刊：FEBS Letters, 页码：2818-2825 , 文章类型： Review，,卷期：2011年585-18] The DDB1-DDB2-CUL4-RBX1 complex serves as the primary detection device for UV-induced lesions in the genome. It simultaneously functions as a CUL4 type E3 ubiquitin ligase. We review the current understanding of this dua... Ubiquitylation of DNA polymerase lambda [作者：Markkanen, E; van Loon, B; Ferrari, E; Hubscher, U,期刊：FEBS Letters, 页码：2826-2830 , 文章类型： Review，,卷期：2011年585-18] DNA polymerase (pol) lambda, one of the 15 cellular pols, belongs to the X family. It is a small 575 amino-acid protein containing a polymerase, a dRP-lyase, a proline/serine rich and a BRCT domain. Pol lambda shows vari... The emerging role of Mule and ARF in the regulation of base excision repair [作者：Khoronenkova, SV; Dianov, GL,期刊：FEBS Letters, 页码：2831-2835 , 文章类型： Review，,卷期：2011年585-18] The ARF (Alternative Reading Frame) protein is encoded in the Ink4a locus of human chromosome 9 that is frequently mutated in cancer cells. It was recently demonstrated that ARF is induced in response to DNA damage and i... The BRCA1 ubiquitin ligase and homologous recombination repair [作者：Ohta, T; Sato, K; Wu, WW,期刊：FEBS Letters, 页码：2836-2844 , 文章类型： Review，,卷期：2011年585-18] Impairment of homologous recombination (HR), a vital process employed during repair of DNA double strand breaks and stalled DNA replication, provides a valuable opportunity for the cell to become transformed. Once transf... COP9 signalosome function in the DDR [作者：Hannss, R; Dubiel, W,期刊：FEBS Letters, 页码：2845-2852 , 文章类型： Review，,卷期：2011年585-18] The COP9 signalosome (CSN) is a platform for protein communication in eukaryotic cells. It has an intrinsic metalloprotease that removes the ubiquitin (Ub)-like protein Nedd8 from cullins. CSN-mediated deneddylation regu... Ubiquitylation and the Fanconi anemia pathway [作者：Garner, E; Smogorzewska, A,期刊：FEBS Letters, 页码：2853-2860 , 文章类型： Review，,卷期：2011年585-18] The Fanconi anemia (FA) pathway maintains genome stability through co-ordination of DNA repair of interstrand crosslinks (ICLs). Disruption of the FA pathway yields hypersensitivity to interstrand crosslinking agents, bo... Timing and spacing of ubiquitin-dependent DNA damage bypass [作者：Ulrich, HD,期刊：FEBS Letters, 页码：2861-2867 , 文章类型： Review，,卷期：2011年585-18] During its duplication, DNA, the carrier of our genetic information, is particularly vulnerable to decay, and the capacity of cells to deal with replication stress has been recognised as a major factor protecting us from... Degradation-linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: New perspectives for anti-cancer therapy [作者：Ramadan, K; Meerang, M,期刊：FEBS Letters, 页码：2868-2875 , 文章类型： Review，,卷期：2011年585-18] Damaged DNA leads to genomic instability that causes many diseases such as cancer. Cells evolved the DNA damage response (DDR), which recognizes and efficiently repairs damaged DNA through the action of highly coordinate... Destroying the ring: Freeing DNA from Ku with ubiquitin [作者：Postow, L,期刊：FEBS Letters, 页码：2876-2882 , 文章类型： Review，,卷期：2011年585-18] The Ku heterodimer, consisting of the proteins Ku70 and Ku80, is the central component of the non-homologous end joining (NHEJ) pathway of double strand break (DSB) repair. Ku is able to recognize and bind a DSB by virtu...