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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   Epigenetics Preface [作者：Issa, JP; Just, W,期刊：FEBS Letters, 页码：1993-1993 , 文章类型： Editorial Material，,卷期：2011年585-13] The DNA methylome [作者：Pelizzola, M; Ecker, JR,期刊：FEBS Letters, 页码：1994-2000 , 文章类型： Review，,卷期：2011年585-13] Methylation of cytosines is a pervasive feature of eukaryotic genomes and an important epigenetic layer that is fundamental for cellular differentiation processes and control of transcriptional potential. DNA methylation... Every methyl counts - Epigenetic calculus [作者：Scharf, AND; Imhof, A,期刊：FEBS Letters, 页码：2001-2007 , 文章类型： Review，,卷期：2011年585-13] Histone modifications play an important role in the formation of an epigenetic memory system that maintains cellular identity. Their complex patterns have been suggested to constitute a histone code, which encodes for sp... DNA methylation systems and targets in plants [作者：Meyer, P,期刊：FEBS Letters, 页码：2008-2015 , 文章类型： Review，,卷期：2011年585-13] Plants contain three distinct DNA methyltransferase types that are responsible for the establishment and maintenance of cytosine methylation patterns at heterochromatic and euchromatic target regions. RNA transcripts pla... The role of deubiquitinating enzymes in chromatin regulation [作者：Atanassov, BS; Koutelou, E; Dent, SY,期刊：FEBS Letters, 页码：2016-2023 , 文章类型： Review，,卷期：2011年585-13] Post-translational modifications of the histones are centrally involved in the regulation of all DNA-templated processes, including gene transcription, DNA replication, recombination, and repair. These modifications are ... Histone arginine methylation [作者：Di Lorenzo, A; Bedford, MT,期刊：FEBS Letters, 页码：2024-2031 , 文章类型： Review，,卷期：2011年585-13] Arginine methylation is a common posttranslational modification (PTM). This type of PTM occurs on both nuclear and cytoplasmic proteins, and is particularly abundant on shuttling proteins. In this review, we will focus o... Environmental sensing by chromatin: An epigenetic contribution to evolutionary change [作者：Turner, BM,期刊：FEBS Letters, 页码：2032-2040 , 文章类型： Review，,卷期：2011年585-13] Chromatin structure and function are regulated by families of protein-modifying enzymes that are sensitive to a variety of metabolic and environmental agents. These enzymes, and proteins that read the modifications they ... Chromatin structure as a mediator of aging [作者：Feser, J; Tyler, J,期刊：FEBS Letters, 页码：2041-2048 , 文章类型： Review，,卷期：2011年585-13] The aging process is characterized by gradual changes to an organism's macromolecules, which negatively impacts biological processes. The complex macromolecular structure of chromatin regulates all nuclear processes requ... Environmental regulation of the neural epigenome [作者：Caldji, C; Hellstrom, IC; Zhang, TY; Diorio, J; Meaney, MJ,期刊：FEBS Letters, 页码：2049-2058 , 文章类型： Review，,卷期：2011年585-13] Parental effects are a major source of phenotypic plasticity. Moreover, there is evidence from studies with a wide range of species that the relevant parental signals are influenced by the quality of the parental environ... Genomic imprinting as an adaptative model of developmental plasticity [作者：Radford, EJ; Ferron, SR; Ferguson-Smith, AC,期刊：FEBS Letters, 页码：2059-2066 , 文章类型： Review，,卷期：2011年585-13] Developmental plasticity can be defined as the ability of one genotype to produce a range of phenotypes in response to environmental conditions. Such plasticity can be manifest at the level of individual cells, an organ,... Polycomb proteins in mammalian cell differentiation and plasticity [作者：Prezioso, C; Orlando, V,期刊：FEBS Letters, 页码：2067-2077 , 文章类型： Review，,卷期：2011年585-13] During development cell differentiation is accompanied by progressive restriction of the developmental potential and increased structural and functional specialization of cells. In this context, mechanisms of cell memory... Dissecting DNA hypermethylation in cancer [作者：Estecio, MRH; Issa, JPJ,期刊：FEBS Letters, 页码：2078-2086 , 文章类型： Review，,卷期：2011年585-13] There is compelling evidence to support the importance of DNA methylation alterations in cancer development. Both losses and gains of DNA methylation are observed, thought to contribute pathophysiologically by inactivati... Dysregulation of microRNAs in cancer: Playing with fire [作者：Melo, SA; Esteller, M,期刊：FEBS Letters, 页码：2087-2099 , 文章类型： Review，,卷期：2011年585-13] MicroRNAs [1] have emerged as key post-transcriptional regulators of gene expression, involved in various physiological and pathological processes. It was found that several miRNAs are directly involved in human cancers,... Transcriptional and epigenetic networks in haematological malignancy [作者：Cheung, N; So, CWE,期刊：FEBS Letters, 页码：2100-2111 , 文章类型： Review，,卷期：2011年585-13] Identification of transcription factors as prevalent targets affected by recurring chromosomal translocations has provided the first hint for the importance of transcriptional deregulation in haematological malignancies.... Translational application of epigenetic alterations: Ovarian cancer as a model [作者：Maradeo, ME; Cairns, P,期刊：FEBS Letters, 页码：2112-2120 , 文章类型： Review，,卷期：2011年585-13] Cancer is a disease initiated and driven by the accumulation and interplay of genetic and epigenetic mutations of genes involved in the regulation of cell growth and signaling. Dysregulation of these genes and pathways i... Epigenetic codes of PPAR gamma in metabolic disease [作者：Sugii, S; Evans, RM,期刊：FEBS Letters, 页码：2121-2128 , 文章类型： Review，,卷期：2011年585-13] Peroxisome proliferator-activated receptor gamma (PPAR gamma), a ligand-regulated nuclear hormone receptor, plays critical roles in metabolism and adipogenesis. PPAR gamma ligands such as thiazolidinediones (TZDs) exert ...