- An HNF4 alpha-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis
[作者:Hatziapostolou, M; Polytarchou, C; Aggelidou, E; Drakaki, A; Poultsides, GA; Jaeger, SA; Ogata, H; Karin, M; Struhl, K; Hadzopoulou-Cladaras, M; Iliopoulos, D,期刊:Cell, 页码:1233-1247 , 文章类型: Article,,卷期:2011年147-6]
- Hepatocyte nuclear factor 4 alpha (HNF4 alpha) is essential for liver development and hepatocyte function. Here, we show that transient inhibition of HNF4 alpha initiates hepatocellular transformation through a microRNA-...
- Cofactor Binding Evokes Latent Differences in DNA Binding Specificity between Hox Proteins
[作者:Slattery, M; Riley, T; Liu, P; Abe, N; Gomez-Alcala, P; Dror, I; Zhou, TY; Rohs, R; Honig, B; Bussemaker, HJ; Mann, RS,期刊:Cell, 页码:1270-1282 , 文章类型: Article,,卷期:2011年147-6]
- Members of transcription factor families typically have similar DNA binding specificities yet execute unique functions in vivo. Transcription factors often bind DNA as multiprotein complexes, raising the possibility that...
- Polycomb-Repressed Genes Have Permissive Enhancers that Initiate Reprogramming
[作者:Taberlay, PC; Kelly, TK; Liu, CC; You, JS; De Carvalho, DD; Miranda, TB; Zhou, XJ; Liang, GN; Jones, PA,期刊:Cell, 页码:1283-1294 , 文章类型: Article,,卷期:2011年147-6]
- Key regulatory genes, suppressed by Polycomb and H3K27me3, become active during normal differentiation and induced reprogramming. Using the well-characterized enhancer/promoter pair of MYOD1 as a model, we have identifie...
- Selective Ribosome Profiling Reveals the Cotranslational Chaperone Action of Trigger Factor In Vivo
[作者:Oh, E; Becker, AH; Sandikci, A; Huber, D; Chaba, R; Gloge, F; Nichols, RJ; Typas, A; Gross, CA; Kramer, G; Weissman, JS; Bukau, B,期刊:Cell, 页码:1295-1308 , 文章类型: Article,,卷期:2011年147-6]
- As nascent polypeptides exit ribosomes, they are engaged by a series of processing, targeting, and folding factors. Here, we present a selective ribosome profiling strategy that enables global monitoring of when these fa...
- The STARD9/Kif16a Kinesin Associates with Mitotic Microtubules and Regulates Spindle Pole Assembly
[作者:Torres, JZ; Summers, MK; Peterson, D; Brauer, MJ; Lee, J; Senese, S; Gholkar, AA; Lo, YC; Lei, XY; Jung, K; Anderson, DC; Davis, DP; Belmont, L; Jackson, PK,期刊:Cell, 页码:1309-1323 , 文章类型: Article,,卷期:2011年147-6]
- During cell division, cells form the microtubule-based mitotic spindle, a highly specialized and dynamic structure that mediates proper chromosome transmission to daughter cells. Cancer cells can show perturbed mitotic s...
- Loss of Tankyrase-Mediated Destruction of 3BP2 Is the Underlying Pathogenic Mechanism of Cherubism
[作者:Levaot, N; Voytyuk, O; Dimitriou, I; Sircoulomb, F; Chandrakumar, A; Deckert, M; Krzyzanowski, PM; Scotter, A; Gu, SQ; Janmohamed, S; Cong, F; Simoncic, PD; Ueki, Y; La Rose, J; Rottapel, R,期刊:Cell, 页码:1324-1339 , 文章类型: Article,,卷期:2011年147-6]
- Cherubism is an autosomal-dominant syndrome characterized by inflammatory destructive bony lesions resulting in symmetrical deformities of the facial bones. Cherubism is caused by mutations in Sh3bp2, the gene that encod...
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