- Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P-2
[作者:Hammond, GRV; Schiavo, G; Irvine, RF,期刊:Biochemical Journal, 页码:23-35 , 文章类型: Article,,卷期:2009年422-Part 1]
- PtdIns4P is the major precursor for the synthesis of the multifunctional plasma membrane lipid, PtdIns(4,5)P-2. Yet PtdIns4P also functions as a regulatory lipid in its own right, particularly at the Golgi apparatus. In ...
- Copper(I)-mediated protein-protein interactions result from suboptimal interaction surfaces
[作者:Banci, L; Bertini, I; Calderone, V; Della-Malva, N; Felli, IC; Neri, S; Pavelkova, A; Rosato, A,期刊:Biochemical Journal, 页码:37-42 , 文章类型: Article,,卷期:2009年422-Part 1]
- The homoeostasis of metal ions in cells is the result of the contribution of several cellular pathways that involve transient, often weak, protein-protein interactions. Metal transfer typically implies the formation of a...
- Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2 beta to the nucleus
[作者:Banfic, H; Visnjic, D; Mise, N; Balakrishnan, S; Deplano, S; Korchev, YE; Domin, J,期刊:Biochemical Journal, 页码:53-60 , 文章类型: Article,,卷期:2009年422-Part 1]
- Although the class II phosphoinositide 3-kinase enzymes PI3K-C2 alpha and PBK-C2 act acutely downstream of cell surface receptors they have also been localized to nuclei in mammalian cells. As with the class I PI3K enzym...
- NCU-G1 is a highly glycosylated integral membrane protein of the lysosome
[作者:Schieweck, O; Damme, M; Schroder, B; Hasilik, A; Schmidt, B; Lubke, T,期刊:Biochemical Journal, 页码:83-90 , 文章类型: Article,,卷期:2009年422-Part 1]
- Until recently, a modest number of approx. 40 lysosomal membrane proteins had been identified and event fewer were characterized in their function. In a proteomic study, using lysosomal membranes from human placenta we i...
- Helicobacter pylori UreE, a urease accessory protein: specific Ni2+- and Zn2+-binding properties and interaction with its cognate UreG
[作者:Bellucci, M; Zambelli, B; Musiani, F; Turano, P; Ciurli, S,期刊:Biochemical Journal, 页码:91-100 , 文章类型: Article,,卷期:2009年422-Part 1]
- The persistence of Helicobacter pylori in the hostile environment of the human stomach is ensured by the activity of urease. The essentiality of Ni2+ for this enzyme demands proper intracellular trafficking of this metal...
- Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts
[作者:Uimari, A; Keinanen, TA; Karppinen, A; Woster, P; Uimari, P; Janne, J; Alhonen, L,期刊:Biochemical Journal, 页码:101-109 , 文章类型: Article,,卷期:2009年422-Part 1]
- SSAT (Spermidine/spermine N-1-acetyltransferase, also known as SAT I), the key enzyme in the catabolism of polyamines, is turned over rapidly and there is only a low amount present in the cell. In the present study, the ...
- Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance
[作者:Skaff, O; Pattison, DI; Davies, MJ,期刊:Biochemical Journal, 页码:111-117 , 文章类型: Article,,卷期:2009年422-Part 1]
- MPO (mycloperoxidase) catalyses the oxidation of chloride, bromide and thiocyanate by H2O2, to HOCl (hypochlorous acid), HOBr (hypobromous acid) and HOSCN (hypothiocyanous acid, also know as cyanosulfenic acid) respectiv...
- Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans
[作者:Tsai, MT; Cheng, CJ; Lin, YC; Chen, CC; Wu, AR; Wu, MT; Hsu, CC; Yang, RB,期刊:Biochemical Journal, 页码:119-128 , 文章类型: Article,,卷期:2009年422-Part 1]
- SCUBE2 [signal peptide, CUB domain, EGF (epidermal growth factor)-like protein 2] belongs to all evolutionarily conserved SCUBE protein family, which possesses domain organization characteristic of an N-terminal signal p...
- Acetylated tubulin associates with the fifth cytoplasmic domain of Na+/K+-ATPase: possible anchorage site of microtubules to the plasma membrane
[作者:Zampar, GG; Chesta, ME; Carbajal, A; Chanaday, NL; Diaz, NM; Casale, CH; Arce, CA,期刊:Biochemical Journal, 页码:129-137 , 文章类型: Article,,卷期:2009年422-Part 1]
- We showed previously that NKA (Na+-/K+-ATPase) interacts with acetylated tubulin resulting in inhibition of its catalytic activity. In the present work we determined that membrane-acetylated tubulin, in the presence of d...
- 8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist
[作者:Kirchberger, T; Moreau, C; Wagner, GK; Fliegert, R; Siebrands, CC; Nebel, M; Schmid, F; Harneit, A; Odoardi, F; Flugel, A; Potter, BVL; Guse, AH,期刊:Biochemical Journal, 页码:139-149 , 文章类型: Article,,卷期:2009年422-Part 1]
- cADPR (cyclic ADP-ribose) is a universal Ca2+ mobilizing second messenger. In T-cells cADPR is involved in sustained Ca2+ release and also in Ca2+ entry. Potential mechanisms for the latter include either capacitative Ca...
- Elevated levels of IL-1 beta in Fanconi anaemia group A patients due to a constitutively active phosphoinositide 3-kinase-Akt pathway are capable of promoting tumour cell proliferation
[作者:Ibanez, A; Rio, P; Casado, JA; Bueren, JA; Fernandez-Luna, JL; Pipaon, C,期刊:Biochemical Journal, 页码:161-170 , 文章类型: Article,,卷期:2009年422-Part 1]
- FA (Fanconi anaemia) is a hereditary disease characterized by congenital malformations, progressive bone marrow failure and an extraordinary elevated predisposition to develop cancer. In the present manuscript we describ...
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