- The Structures of Coiled-Coil Domains from Type III Secretion System Translocators Reveal Homology to Pore-Forming Toxins
[作者:Barta, ML; Dickenson, NE; Patil, M; Keightley, A; Wyckoff, GJ; Picking, WD; Picking, WL; Geisbrecht, BV,期刊:Journal of Molecular Biology, 页码:395-405 , 文章类型: Article,,卷期:2012年417-5]
- Many pathogenic Gram-negative bacteria utilize type III secretion systems (T3SSs) to alter the normal functions of target cells. Shigella flexneri uses its T3SS to invade human intestinal cells to cause bacillary dysente...
- The Role of Hydration in Protein Stability: Comparison of the Cold and Heat Unfolded States of Yfh1
[作者:Adrover, M; Martorell, G; Martin, SR; Urosev, D; Konarev, PV; Svergun, DI; Daura, X; Temussi, P; Pastore, A,期刊:Journal of Molecular Biology, 页码:413-424 , 文章类型: Article,,卷期:2012年417-5]
- Protein unfolding occurs at both low and high temperatures, although in most cases, only the high-temperature transition can be experimentally studied. A pressing question is how much the low- and high-temperature denatu...
- Protein Synthesis Factors (RF1, RF2, RF3, RRF, and tmRNA) and Peptidyl-tRNA Hydrolase Rescue Stalled Ribosomes at Sense Codons
[作者:Vivanco-Dominguez, S; Bueno-Martinez, J; Leon-Avila, G; Iwakura, N; Kaji, A; Kaji, H; Guarneros, G,期刊:Journal of Molecular Biology, 页码:425-439 , 文章类型: Article,,卷期:2012年417-5]
- During translation, ribosomes stall on mRNA when the aminoacyl-tRNA to be read is not readily available. The stalled ribosomes are deleterious to the cell and should be rescued to maintain its viability. To investigate t...
- The NOXO1 beta PX Domain Preferentially Targets PtdIns(4,5)P-2 and PtdIns(3,4,5)P-3
[作者:Davis, NY; McPhail, LC; Horita, DA,期刊:Journal of Molecular Biology, 页码:440-453 , 文章类型: Article,,卷期:2012年417-5]
- NOX1 beta [NOXO1 (Nox organizer 1) beta] is a cytosolic protein that, in conjunction with NOXA1 (Nox activator 1), regulates generation of reactive oxygen species by the NADPH oxidase 1 (Nox1) enzyme complex. NOX1 beta i...
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