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  • LINE-1 ORF1 protein enhances Alu SINE retrotransposition
    [作者:Wallace, N; Wagstaff, BJ; Deininger, PL; Roy-Engel, AM,期刊:Gene, 页码:1-6 , 文章类型: Article,,卷期:2008年419-1-2]
  • Retroelements have contributed over one third of the human genome mass. The currently active LINE-1 (L1) codes for two proteins (ORF1p and ORF2p), both strictly required for retrotransposition. In contrast, the non-codin...
  • Mapping DNase-I hypersensitive sites on human isochores
    [作者:Di Filippo, M; Bernardi, G,期刊:Gene, 页码:62-65 , 文章类型: Article,,卷期:2008年419-1-2]
  • Mapping DNase-I hypersensitive sites (HS) was used in the past to identify regulatory elements of specific genes. More recently, thousands of HS were identified in the human genome by using high-throughput methods. These...
  • Extrapolating ENCODE data to the whole human genome
    [作者:Costantini, M; Di Filippo, M; Bernardi, G,期刊:Gene, 页码:66-69 , 文章类型: Article,,卷期:2008年419-1-2]
  • The ENCODE (ENCyclopedia Of DNA Elements) project was launched three years ago with the purpose of identifying all of the functional elements in the human genome. ENCODE was started with 44 target sequences, which compri...
  • Marker removal from actinomycetes genome using Flp recombinase
    [作者:Fedoryshyn, M; Petzke, L; Welle, E; Bechthold, A; Luzhetskyy, A,期刊:Gene, 页码:43-47 , 文章类型: Article,,卷期:2008年419-1-2]
  • We report here a system for the functional expression of the Flp recombinase in several actinomycetes: Streptomyces coelicolor, S. lividans, and Saccharotrix espanaensis. We have constructed a synthetic gene encoding the...
  • L1 mobile element expression causes multiple types of toxicity
    [作者:Wallace, NA; Belancio, VP; Deininger, PL,期刊:Gene, 页码:75-81 , 文章类型: Article,,卷期:2008年419-1-2]
  • LINE-1 (L1) retrotransposons represent one of the most successful families of autonomous retroelements, accounting for at least 17% of the human genome. The expression of these elements can be deleterious to a cell. L1 e...