- Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: Novel 5-fluorouracil analogs that target thymidylate synthase
[作者:Tzioumaki, N; Manta, S; Tsoukala, E; Voorde, JV; Liekens, S; Komiotis, D; Balzarini, J,期刊:European Journal of Medicinal Chemistry, 页码:993-1005 , 文章类型: Article,,卷期:2011年46-4]
- The synthesis of pyrimidine unsaturated keto and exomethylene arabinopyranonucleoside analogs as potential antitumor and antiviral agents is described. Commercially available 1,2,3,4-tetra-O-acetyl-D-arabinopyranose (1) ...
- Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent
[作者:Im, WB; Choi, SH; Park, JY; Choi, SH; Finn, J; Yoon, SH,期刊:European Journal of Medicinal Chemistry, 页码:1027-1039 , 文章类型: Article,,卷期:2011年46-4]
- A series of novel substituted pyridyl phenyl oxazolidinone analogues were synthesized and their structure-activity relationship (SAR) was investigated based on in vitro and in vivo antibacterial activities. The minimum i...
- Synthesis of some novel 3-(1-(1-substitutedpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)-5-substituted phenyl-1,2,4-oxadiazoles as antifungal agents
[作者:Sangshetti, JN; Shinde, DB,期刊:European Journal of Medicinal Chemistry, 页码:1040-1044 , 文章类型: Article,,卷期:2011年46-4]
- A novel series of 3-(1-(1-substituted piperidin-4-yl)-1H-1,2,3-triazol-4-yl)-5-substituted phenyl-1,2, 4-oxadiazoles bearing 1,2,3-triazole and piperidine ring has been synthesized in one step from amidoxime using Carbon...
- Synthesis of 9-substituted derivatives of berberine as anti-HIV agents
[作者:Bodiwala, HS; Sabde, S; Mitra, D; Bhutani, KK; Singh, IP,期刊:European Journal of Medicinal Chemistry, 页码:1045-1049 , 文章类型: Article,,卷期:2011年46-4]
- Naturally occurring protoberberine alkaloids, berberine and berberrubine along with 9-substituted derivatives of berberine were assessed for the anti-human immunodeficiency virus (HIV) activity. Berberine was found to be...
- Synthesis and anticonvulsant activity of 8-alkoxy-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepin-1-one derivatives
[作者:Piao, FY; Han, RB; Zhang, W; Zhang, WB; Jiang, RS,期刊:European Journal of Medicinal Chemistry, 页码:1050-1055 , 文章类型: Article,,卷期:2011年46-4]
- A series of novel 8-alkoxy-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepin-1-one derivatives were synthesized and screened for their anticonvulsant activities by the maximal electroshock (MES) test, subcutaneous penty...
- Synthesis, DNA-binding and topoisomerase inhibitory activity of ruthenium(II) polypyridyl complexes
[作者:Du, KJ; Wang, JQ; Kou, JF; Li, GY; Wang, LL; Chao, H; Ji, LN,期刊:European Journal of Medicinal Chemistry, 页码:1056-1065 , 文章类型: Article,,卷期:2011年46-4]
- Two ruthenium(II) complexes [Ru(bpy)(2)(bfipH)](2+) (I) and [Ru(phen)(2)(bfipH)](2+) (2) have been synthesized and characterized. The DNA-binding behaviors of complexes were studied by using spectroscopic and viscosity m...
- Synthesis and structure-activity relationship of N-(2-arylethyl) isoquinoline derivatives as human scavenger receptor CD36 antagonists
[作者:Wang, YX; Wang, L; Xu, YN; Li, YH; Jiang, JD; Si, SY; Li, YB; Ren, G; Shan, YQ; Hong, B; Song, DQ,期刊:European Journal of Medicinal Chemistry, 页码:1066-1073 , 文章类型: Article,,卷期:2011年46-4]
- By using human scavenger receptor CD36 as the target, twenty-five N-(2-arylethyl) isoquinoline derivatives were designed, synthesized and evaluated for their antagonistic activities for CD36-oxidatively low density lipop...
- Using entropy of drug and protein graphs to predict FDA drug-target network: Theoretic-experimental study of MAO inhibitors and hemoglobin peptides from Fasciola hepatica
[作者:Prado-Prado, F; Garcia-Mera, X; Abeijon, P; Alonso, N; Caamano, O; Yanez, M; Garate, T; Mezo, M; Gonzalez-Warleta, M; Muino, L; Ubeira, FM; Gonzalez-Diaz, H,期刊:European Journal of Medicinal Chemistry, 页码:1074-1094 , 文章类型: Article,,卷期:2011年46-4]
- There are many drugs described with very different affinity to a large number of receptors. In this work, we selected Drug-Target pairs (DTPs/nDTPs) of drugs with high affinity/non-affinity for different targets like pro...
- Antibodies against beta-fibrin synthetic peptides: A study of their association with the immunogenetic background and disease course of rheumatoid arthritis patients
[作者:Haro, I; Gomara, MJ; Perez, ML; Vinas, O; Ercilla, G; Gomez-Puerta, JA; Sanmarti, R,期刊:European Journal of Medicinal Chemistry, 页码:1095-1102 , 文章类型: Article,,卷期:2011年46-4]
- Preliminary studies have shown the potential application for the diagnosis of Rheumatoid Arthritis (RA) patients with a severe disease course of an epitopic domain of beta-fibrin. The aim of the present work was the anal...
- Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity
[作者:Chorell, E; Bengtsson, C; Banchelin, TS; Das, P; Uvell, H; Sinha, AK; Pinkner, JS; Hultgren, SJ; Almqvist, F,期刊:European Journal of Medicinal Chemistry, 页码:1103-1116 , 文章类型: Article,,卷期:2011年46-4]
- Pilicides are a class of compounds that attenuate virulence in Gram negative bacteria by blocking the chaperone/usher pathway in Escherichia coli. It has also been shown that compounds derived from the peptidomimetic sca...
- Identification, structural properties and chelating capacity of miltipolone as a broad-spectrum inhibitor to cancer cells
[作者:Wang, J; Chen, SP; Cheng, H; Yang, FY; Wan, JT; Bo, JA; Liu, YX; Yang, JY; Liu, JS; Zhou, GC,期刊:European Journal of Medicinal Chemistry, 页码:1117-1121 , 文章类型: Article,,卷期:2011年46-4]
- Miltipolone (1) was discovered as a good and broad-spectrum inhibitor against the growth of cancer cells from "Danshen" based on the activity-driven screening of TCMs. The structural features make 1 easily tautomerize be...
- Design of semisynthetic analogues and 3D-QSAR study of eunicellin-based diterpenoids as prostate cancer migration and invasion inhibitors
[作者:Hassan, HM; Elnagar, AY; Khanfar, MA; Sallam, AA; Mohammed, R; Shaala, LA; Youssef, DTA; Hifnawy, MS; El Sayed, KA,期刊:European Journal of Medicinal Chemistry, 页码:1122-1130 , 文章类型: Article,,卷期:2011年46-4]
- Prostrate cancer constitutes the second leading cause of cancer deaths in men in United States. Eunicellin-based diterpenoids are important bioactive marine natural products isolated from corals of alcyonaria species. Th...
- Carbaboranes as pharmacophores: Similarities and differences between aspirin and asborin
[作者:Scholz, M; Kaluderovic, GN; Kommera, H; Paschke, R; Will, J; Sheldrick, WS; Hey-Hawkins, E,期刊:European Journal of Medicinal Chemistry, 页码:1131-1139 , 文章类型: Article,,卷期:2011年46-4]
- In medicinal chemistry carbaboranes have been used almost exclusively as boron carriers for boron neutron capture therapy (BNCT). Recent developments extended the carrier approach and use carbaboranes as scaffolds for ra...
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