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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共9条记录   Targeting the diverse immunological functions expressed by hepatic NKT cells [作者：Duwaerts, CC; Gregory, SH,期刊：Expert Opinion on Therapeutic Targets, 页码：973-988 , 文章类型： Review，,卷期：2011年15-8] Introduction: NKT cells comprise approximately 30% of the hepatic lymphoid population in mice (similar to 50% in humans). Most mouse hepatic NKT cells [invariant (i) NKT cells] express T cell receptors, composed of invar... Connexins as therapeutic targets in lung disease [作者：Losa, D; Chanson, M; Crespin, S,期刊：Expert Opinion on Therapeutic Targets, 页码：989-1002 , 文章类型： Review，,卷期：2011年15-8] Introduction: The lung is a mechanically active system exposed to the external environment and is particularly sensitive to injury and inflammation. Studies have identified intercellular communication pathways that promo... Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in man [作者：Hendriks, RW; Bredius, RGM; Pike-Overzet, K; Staal, FJT,期刊：Expert Opinion on Therapeutic Targets, 页码：1003-1021 , 文章类型： Review，,卷期：2011年15-8] Introduction: X-linked agammaglobulinemia (XLA) is the most common primary immunodeficiency in man, and is caused by a single genetic defect. Inactivating mutations in the Bruton's tyrosine kinase (BTK) gene are invariab... HMGB1, TLR and RAGE: a functional tripod that leads to diabetic inflammation [作者：Nogueira-Machado, JA; Volpe, CMD; Veloso, CA; Chaves, MM,期刊：Expert Opinion on Therapeutic Targets, 页码：1023-1035 , 文章类型： Review，,卷期：2011年15-8] Introduction: Despite advances in treatment of diabetes mellitus, its prevalence continues to rise globally. Medications available are unable to control the vascular complications. Proposals for new therapeutic targets m... The Therapeutic Target Database: an Internet resource for the primary targets of approved, clinical trial and experimental drugs [作者：Liu, X; Zhu, F; Ma, XH; Tao, L; Zhang, JX; Yang, SY; Wei, YQ; Chen, YZ,期刊：Expert Opinion on Therapeutic Targets, 页码：903-912 , 文章类型： Editorial Material，,卷期：2011年15-8] Increasing numbers of proteins, nucleic acids and other molecular entities have been explored as therapeutic targets. A challenge in drug discovery is to decide which targets to pursue from an increasing pool of potentia... Peyronie's disease: perspectives on therapeutic targets [作者：Abdel-Hamid, IA; Anis, T,期刊：Expert Opinion on Therapeutic Targets, 页码：913-929 , 文章类型： Review，,卷期：2011年15-8] Introduction: Peyronie's disease (PD) is an acquired benign connective tissue disorder of the penis, characterized by the development of fibrotic plaques, that can cause different degrees of bending, narrowing or shorten... Molecular targets for selective killing of TRAIL-resistant leukemic cells [作者：Zauli, G; Bosco, R; Secchiero, P,期刊：Expert Opinion on Therapeutic Targets, 页码：931-942 , 文章类型： Review，,卷期：2011年15-8] Introduction: TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines, and shows promising therapeutic activity against solid tumors and lymphomas, in a variety of Phase I and II clinical... Targeting the peroxisome proliferator-activated receptors (PPARs) in spinal cord injury [作者：Esposito, E; Cuzzocrea, S,期刊：Expert Opinion on Therapeutic Targets, 页码：943-959 , 文章类型： Review，,卷期：2011年15-8] Introduction: Traumatic spinal cord injury (SCI) causes severe and permanent functional deficits, due to the primary mechanical insult, followed by secondary tissue degeneration. The direct damage is followed by a second... Targeting miR-375 in gastric cancer [作者：Xu, YJ; Deng, YJ; Yan, XY; Zhou, TH,期刊：Expert Opinion on Therapeutic Targets, 页码：961-972 , 文章类型： Review，,卷期：2011年15-8] Introduction: Gastric cancer remains a major cancer burden in the world, with a poor 5-year survival rate. It is necessary to develop new effective therapeutic strategies to improve the long-term clinical outcome. MicroR...