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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   The role of Raf-1 kinase in diabetic retinopathy [作者：Mohammad, G; Kowluru, RA,期刊：Expert Opinion on Therapeutic Targets, 页码：357-364 , 文章类型： Editorial Material，,卷期：2011年15-4] Many metabolic pathways, including oxidative stress, PKC and the polyol pathway have been implicated in the development of diabetic retinopathy, but despite extensive research, its pathogenesis remains unclear. Recent st... Threonine peptidases as drug targets against malaria [作者：Tschan, S; Mordmuller, B; Kun, JFJ,期刊：Expert Opinion on Therapeutic Targets, 页码：365-378 , 文章类型： Review，,卷期：2011年15-4] Areas covered: This review discusses research on plasmodial threonine peptidases along with recent advances in proteasome inhibitor development. Expert opinion: While PfHslV is an attractive drug target in malaria, more ... Pathobiological targets of depression [作者：Chopra, K; Kumar, B; Kuhad, A,期刊：Expert Opinion on Therapeutic Targets, 页码：379-400 , 文章类型： Review，,卷期：2011年15-4] Areas covered: The various pathological factors involved in depression are: monoamine hypothesis, neurotransmitter receptor hypothesis, neurotrophic factor hypothesis, hypothalamic--pituitary--adrenal (HPA) dysregulation... Effect of various treatments on leptin, adiponectin, ghrelin and neuropeptide Y in patients with type 2 diabetes mellitus [作者：Katsiki, N; Mikhailidis, DP; Gotzamani-Psarrakou, A; Yovos, JG; Karamitsos, D,期刊：Expert Opinion on Therapeutic Targets, 页码：401-420 , 文章类型： Review，,卷期：2011年15-4] Areas covered: The present review considers: i) the role of leptin, adiponectin, ghrelin and NPY in patients with T2DM, and, ii) the effect of insulin as well as oral hypoglycemic, antihypertensive, hypolipidemic, antiob... Targeting integrins in hepatocellular carcinoma [作者：Wu, YH; Qiao, XJ; Qiao, SY; Yu, L,期刊：Expert Opinion on Therapeutic Targets, 页码：421-437 , 文章类型： Review，,卷期：2011年15-4] Areas covered: This review summarizes the current knowledge of integrins involved in HCC and the potential of integrin-targeted drugs in HCC therapy. A brief introduction on the structure, biological function and regulat... Common pathogenic mechanisms and pathways in the development of COPD and lung cancer [作者：Yang, IA; Relan, V; Wright, CM; Davidson, MR; Sriram, KB; Francis, SMS; Clarke, BE; Duhig, EE; Bowman, RV; Fong, KM,期刊：Expert Opinion on Therapeutic Targets, 页码：439-456 , 文章类型： Review，,卷期：2011年15-4] Areas covered: This review discusses the common mechanisms for susceptibility to lung cancer and COPD, which in addition to cigarette smoke, may involve inflammation, epithelial--mesenchymal transition, abnormal repair, ... The molecular pathogenesis and management of bronchial carcinoids [作者：Cakir, M; Grossman, A,期刊：Expert Opinion on Therapeutic Targets, 页码：457-491 , 文章类型： Review，,卷期：2011年15-4] Areas covered: The molecular biology and novel molecular pathways and drug targets in bronchial carcinoids are reviewed in this paper. A full data search is performed through PubMed over the years 2000 -- 2010 with key w... Hedgehog-mediated regulation of thyroid hormone action through iodothyronine deiodinases [作者：Dentice, M,期刊：Expert Opinion on Therapeutic Targets, 页码：493-504 , 文章类型： Review，,卷期：2011年15-4] Areas covered: Recent evidences from two independent systems implicate the Hh signaling pathway in regulation of TH action via modulation of deiodinase expression. Interestingly, many critical developmental events, for e... Spinal cord injury therapies in humans: an overview of current clinical trials and their potential effects on intrinsic CNS macrophages [作者：Gensel, JC; Donnelly, DJ; Popovich, PG,期刊：Expert Opinion on Therapeutic Targets, 页码：505-518 , 文章类型： Review，,卷期：2011年15-4] Areas covered: This review provides a comprehensive overview of current SCI clinical trials that are intended to promote neuroprotection, axon regeneration or cell replacement. None of these potential therapies were deve... Targets of chymase inhibitors [作者：Takai, S; Jin, DN; Miyazaki, M,期刊：Expert Opinion on Therapeutic Targets, 页码：519-527 , 文章类型： Review，,卷期：2011年15-4] Areas covered: This review discusses the appropriate targets and safety of chymase inhibitors. Six diseases with notable mortality or morbidity as targets of chymase inhibitors are focused on; abdominal aortic aneurysms ...