- Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine
[作者:Corti, D; Suguitan, AL; Pinna, D; Silacci, C; Fernandez-Rodriguez, BM; Vanzetta, F; Santos, C; Luke, CJ; Torres-Velez, FJ; Temperton, NJ; Weiss, RA; Sallusto, F; Subbarao, K; Lanzavecchia, A,期刊:Journal of clinical investigation, 页码:1663-1673 , 文章类型: Article,,卷期:2010年120-5]
- The target of neutralizing antibodies that protect against influenza virus infection is the viral protein HA. Genetic and antigenic variation in HA has been used to classify influenza viruses into subtypes (H1-H16). The ...
- Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population
[作者:Antonelli, LRV; Rothfuchs, AG; Goncalves, R; Roffe, E; Cheever, AW; Bafica, A; Salazar, AM; Feng, CG; Sher, A,期刊:Journal of clinical investigation, 页码:1674-1682 , 文章类型: Article,,卷期:2010年120-5]
- Type I IFN has been demonstrated to have major regulatory effects on the outcome of bacterial infections. To assess the effects of exogenously induced type I IFN on the outcome of Mycobacterium tuberculosis infection, we...
- Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain
[作者:Shi, MQ; Li, SS; Zheng, CF; Jones, GJ; Kim, KS; Zhou, H; Kubes, P; Mody, CH,期刊:Journal of clinical investigation, 页码:1683-1693 , 文章类型: Article,,卷期:2010年120-5]
- Infectious meningitis and encephalitis is caused by invasion of circulating pathogens into the brain. It is unknown how the circulating pathogens dynamically interact with brain endothelium under shear stress, leading to...
- Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development
[作者:Lin, FJ; Chen, XP; Qin, J; Hong, YK; Tsai, MJ; Tsai, SY,期刊:Journal of clinical investigation, 页码:1694-1707 , 文章类型: Article,,卷期:2010年120-5]
- The lymphatic system plays a key role in tissue fluid homeostasis. Lymphatic dysfunction contributes to the pathogenesis of many human diseases, including lymphedema and tumor metastasis. However, the mechanisms regulati...
- Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival
[作者:Mellitzer, G; Beucher, A; Lobstein, V; Michel, P; Robine, S; Kedinger, M; Gradwohl, G,期刊:Journal of clinical investigation, 页码:1708-1721 , 文章类型: Article,,卷期:2010年120-5]
- At least 10 enteroendocrine cell types have been identified, and the peptide hormones they secrete have diverse functions that include regulation of glucose homeostasis, food intake, and gastric emptying. Mice lacking in...
- Group III secreted phospholipase A(2) regulates epididymal sperm maturation and fertility in mice
[作者:Sato, H; Taketomi, Y; Isogai, Y; Miki, Y; Yamamoto, K; Masuda, S; Hosono, T; Arata, S; Ishikawa, Y; Ishii, T; Kobayashi, T; Nakanishi, H; Ikeda, K; Taguchi, R; Hara, S; Kudo, I; Murakami, M,期刊:Journal of clinical investigation, 页码:1400-1414 , 文章类型: Article,,卷期:2010年120-5]
- Although lipid metabolism is thought to be important for the proper maturation and function of spermatozoa, the molecular mechanisms that underlie this dynamic process in the gonads remains incompletely understood. Here,...
- Group X phospholipase A(2) is released during sperm acrosome reaction and controls fertility outcome in mice
[作者:Escoffier, J; Jemel, I; Tanemoto, A; Taketomi, Y; Payre, C; Coatrieux, C; Sato, H; Yamamoto, K; Masuda, S; Pernet-Gallay, K; Pierre, V; Hara, S; Murakami, M; De Waard, M; Lambeau, G; Arnoult, C,期刊:Journal of clinical investigation, 页码:1415-1428 , 文章类型: Article,,卷期:2010年120-5]
- Ejaculated mammalian sperm must undergo a maturation process called capacitation before they are able to fertilize an egg. Several studies have suggested a role for members of the secreted phospholipase Ay (sPLA(2)) fami...
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