- PBSCs Sphingoling along S1P/S1P(1) axis
[作者：Christopherson, KW,期刊：Blood, 页码：645-646 , 文章类型： Editorial Material，,卷期：2012年119-3]
- In this issue of Blood, Juarez and colleagues reveal a need for the Sphingosine-1-Phosphate/S1P receptor 1 (S1P/S1P(1)) axis in the egress of hematopoietic stem cells/hematopoietic progenitor cells (HSCs/HPCs) from the b...
- Functional transfer of microRNA by exosomes
[作者：Stoorvogel, W,期刊：Blood, 页码：646-648 , 文章类型： Editorial Material，,卷期：2012年119-3]
- Cells can communicate directly with each other through cell-cell contact or at a distance using secreted soluble mediators. A third mode of intercellular communication may be mediated by exosomes, an emerging novel pathw...
- GRPling with PTEN
[作者：Barber, DL,期刊：Blood, 页码：648-649 , 文章类型： Editorial Material，,卷期：2012年119-3]
- Regulation of the Pten tumor suppressor is complex and mediated by varied mechanisms. In this issue of Blood, Wey and colleagues show in a biallelic conditional knockout mouse model of GRP78 and PTEN that heterozygous lo...
- Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey
[作者：Aggarwal, BB; Gupta, SC; Kim, JH,期刊：Blood, 页码：651-665 , 文章类型： Review，,卷期：2012年119-3]
- Although activity that induced tumor regression was observed and termed tumor necrosis factor (TNF) as early as the 1960s, the true identity of TNF was not clear until 1984, when Aggarwal and co-workers reported, for the...
- Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients
[作者：Shapiro, AD; Ragni, MV; Valentino, LA; Key, NS; Josephson, NC; Powel, JS; Cheng, G; Thompson, AR; Goyal, J; Tubridy, KL; Peters, RT; Dumont, JA; Euwart, D; Li, L; Hallen, B; Gozzi, P; Bitonti, AJ; Jiang, HY; Luk, A; Pierce, GF,期刊：Blood, 页码：666-672 , 文章类型： Article，,卷期：2012年119-3]
- Current factor IX (FIX) products display a half-life (t(1/2)) of similar to 18 hours, requiring frequent intravenous infusions for prophylaxis and treatment in patients with hemophilia B. This open-label, dose-escalation...
- EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases
[作者：Kimura, H; Ito, Y; Kawabe, S; Gotoh, K; Takahashi, Y; Kojima, S; Naoe, T; Esaki, S; Kikuta, A; Sawada, A; Kawa, K; Ohshima, K; Nakamura, S,期刊：Blood, 页码：673-686 , 文章类型： Article，,卷期：2012年119-3]
- EBV-associated T/NK cell lymphoproliferative disease (T/NK-LPD) is defined as a systemic illness characterized by clonal proliferation of EBV-infected T or NK cells. We prospectively enrolled 108 nonimmunocompromised pat...
- High-risk cytogenetics and persistent minimal residual disease by multiparameter flow cytometry predict unsustained complete response after autologous stem cell transplantation in multiple myeloma
[作者：Paiva, B; Gutierrez, NC; Rosinol, L; Vidriales, MB; Montalban, MA; Martinez-Lopez, J; Mateos, MV; Cibeira, MT; Cordon, L; Oriol, A; Terol, MJ; Echeveste, MA; de Paz, R; de Arriba, F; Palomera, L; de la Rubia, J; Diaz-Mediavilla, J; Sureda, A; Gorosquieta, A; Alegre, A; Martin, A; Hernandez, MT; Lahuerta, JJ; Blade, J; Migue, JFS,期刊：Blood, 页码：687-691 , 文章类型： Article，,卷期：2012年119-3]
- The achievement of complete response (CR) after high-dose therapy/autologous stem cell transplantation (HDT/ASCT) is a surrogate for prolonged survival in multiple myeloma; however, patients who lose their CR status with...
- A retrospective multicenter analysis of elderly Hodgkin lymphoma: outcomes and prognostic factors in the modern era
[作者：Evens, AM; Helenowski, I; Ramsdale, E; Nabhan, C; Karmali, R; Hanson, B; Parsons, B; Smith, S; Larsen, A; McKoy, JM; Jovanoyic, B; Gregory, S; Gordon, LI; Smith, SM,期刊：Blood, 页码：692-695 , 文章类型： Article，,卷期：2012年119-3]
- investigated a recent (January 1999 to December 2009) cohort of 95 elderly Hodgkin lymphoma subjects. At diagnosis, median age was 67 years (range, 60-89 years), whereas 61% had significant comorbidity, 26% were unfit, 1...
- CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo
[作者：Song, DG; Ye, QR; Poussin, M; Harms, GM; Figini, M; Powell, DJ,期刊：Blood, 页码：696-706 , 文章类型： Article，,卷期：2012年119-3]
- The costimulatory effects of CD27 on T lymphocyte effector function and memory formation has been confined to evaluations in mouse models, in vitro human cell culture systems, and clinical observations. Here, we tested w...
- Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice
[作者：Juarez, JG; Harun, N; Thien, M; Welschinger, R; Baraz, R; Dela Pena, A; Pitson, SM; Rettig, M; DiPersio, JF; Bradstock, KF; Bendall, LJ,期刊：Blood, 页码：707-716 , 文章类型： Article，,卷期：2012年119-3]
- CXCL12 and VCAM1 retain hematopoietic stem cells (HSCs) in the BM, but the factors mediating HSC egress from the BM to the blood are not known. The sphingosine-1-phosphate receptor 1 (S1P(1)) is expressed on HSCs, and S1...
- Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis
[作者：Carbonneau, CL; Despars, G; Rojas-Sutterlin, S; Fortin, A; Le, O; Hoang, T; Beausejour, CM,期刊：Blood, 页码：717-726 , 文章类型： Article，,卷期：2012年119-3]
- Alterations of the BM microenvironment have been shown to occur after chemoradiotherapy, during aging, and after genetic manipulations of telomere length. Nevertheless, whether BM stromal cells adopt senescent features i...
- Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development
[作者：Lane, SW; De Vita, S; Alexander, KA; Karaman, R; Milsom, MD; Dorrance, AM; Purdon, A; Louis, L; Bouxsein, ML; Williams, DA,期刊：Blood, 页码：736-744 , 文章类型： Article，,卷期：2012年119-3]
- Hematopoietic stem cells (HSCs) interact with osteoblastic, stromal, and vascular components of the BM hematopoietic microenvironment (HM) that are required for the maintenance of long-term self-renewal in vivo. Osteobla...
- Expansion of CD8(+) T cells lacking Sema4D/CD100 during HIV-1 infection identifies a subset of T cells with decreased functional capacity
[作者：Eriksson, EM; Milush, JM; Ho, EL; Batista, MD; Holditch, SJ; Keh, CE; Norris, PJ; Keating, SM; Deeks, SG; Hunt, PW; Martin, JN; Rosenberg, MG; Hecht, FM; Nixon, DF,期刊：Blood, 页码：745-755 , 文章类型： Article，,卷期：2012年119-3]
- Sema4D, also known as CD100, is a constitutively expressed immune semaphorin on T cells and NK cells. CD100 has important immune regulatory functions that improve antigen-specific priming by antigen-presenting cells, and...
- Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes
[作者：Montecalvo, A; Larregina, AT; Shufesky, WJ; Stolz, DB; Sullivan, MLG; Karlsson, JM; Baty, CJ; Gibson, GA; Erdos, G; Wang, ZL; Milosevic, J; Tkacheva, OA; Divito, SJ; Jordan, R; Lyons-Weiler, J; Watkins, SC; Morelli, AE,期刊：Blood, 页码：756-766 , 文章类型： Article，,卷期：2012年119-3]
- Dendritic cells (DCs) are the most potent APCs. Whereas immature DCs down-regulate T-cell responses to induce/maintain immunologic tolerance, mature DCs promote immunity. To amplify their functions, DCs communicate with ...
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