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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共37条记录   A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice [作者：Frecha, C; Costa, C; Negre, D; Amirache, F; Trono, D; Rio, P; Bueren, J; Cosset, FL; Verhoeyen, E,期刊：Blood, 页码：1139-1150 , 文章类型： Article，,卷期：2012年119-5] In vivo lentiviral vector (LV)-mediated gene delivery would represent a great step forward in the field of gene therapy. Therefore, we have engineered a novel LV displaying SCF and a mutant cat endogenous retroviral glyc... ECSASB2 mediates MLL degradation during hematopoietic differentiation [作者：Wang, JY; Muntean, AG; Hess, JL,期刊：Blood, 页码：1151-1161 , 文章类型： Article，,卷期：2012年119-5] Mixed lineage leukemia (MLL) is a key epigenetic regulator of normal hematopoietic development and chromosomal translocations involving MLL are one of the most common genetic alterations in human leukemia. Here we show t... Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia [作者：Sampath, D; Liu, CM; Vasan, K; Sulda, M; Puduvalli, VK; Wierda, WG; Keating, MJ,期刊：Blood, 页码：1162-1172 , 文章类型： Article，,卷期：2012年119-5] Chronic lymphocytic leukemia (CLL) demonstrates a global down-regulation of miR-15a and miR-16 and a selective silencing of the related miR-29b in aggressive disease. Deletions in chromosome 13 [del(13q14)] partially acc... The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax [作者：Fryrear, KA; Guo, X; Kerscher, O; Semmes, OJ,期刊：Blood, 页码：1173-1181 , 文章类型： Article，,卷期：2012年119-5] The Really Interesting New Gene (RING) Finger Protein 4 (RNF4) represents a class of ubiquitin ligases that target Small Ubiquitin-like Modifier (SUMO)-modified proteins for ubiquitin modification. To date, the regulator... The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo [作者：Ponader, S; Chen, SS; Buggy, JJ; Balakrishnan, K; Gandhi, V; Wierda, WG; Keating, MJ; O'Brien, S; Chiorazzi, N; Burger, JA,期刊：Blood, 页码：1182-1189 , 文章类型： Article，,卷期：2012年119-5] B-cell receptor (BCR) signaling is a critical pathway in the pathogenesis of several B-cell malignancies, including chronic lymphocytic leukemia (CLL), and can be targeted by inhibitors of BCR-associated kinases, such as... The cell cycle regulator CDC25A is a target for JAK2(V617F) oncogene [作者：Gautier, EF; Picard, M; Laurent, C; Marty, C; Villeval, JL; Demur, C; Delhommeau, F; Hexner, E; Giraudier, S; Bonnevialle, N; Ducommun, B; Recher, C; Laurent, G; Manenti, S; Mansat-De Mas, V,期刊：Blood, 页码：1190-1199 , 文章类型： Article，,卷期：2012年119-5] The JAK2(V617F) mutation is present in the majority of patients with polycythemia vera and one-half of those with essential thrombocythemia and primary myelofibrosis. JAK2(V617F) is a gain-of-function mutation resulting ... A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside [作者：McDermott, SP; Eppert, K; Notta, F; Isaac, M; Datti, A; Al-awar, R; Wrana, J; Minden, MD; Dick, JE,期刊：Blood, 页码：1200-1207 , 文章类型： Article，,卷期：2012年119-5] Gene regulatory networks that govern hematopoietic stem cells (HSCs) and leukemia-initiating cells (L-ICs) are deeply entangled. Thus, the discovery of compounds that target L-ICs while sparing HSC is an attractive but d... Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms [作者：Score, J; Hidalgo-Curtis, C; Jones, AV; Winkelmann, N; Skinner, A; Ward, D; Zoi, K; Ernst, T; Stegelmann, F; Dohner, K; Chase, A; Cross, NCP,期刊：Blood, 页码：1208-1213 , 文章类型： Article，,卷期：2012年119-5] The polycomb repressive complex 2 (PRC2) is a highly conserved histone H3 lysine 27 methyltransferase that regulates the expression of developmental genes. Inactivating mutations of the catalytic component of PRC2, EZH2,... Killing by neutrophil extracellular traps: fact or folklore? [作者：Menegazzi, R; Decleva, E; Dri, P,期刊：Blood, 页码：1214-1216 , 文章类型： Article，,卷期：2012年119-5] Neutrophil extracellular traps (NETs) are DNA structures released by dying neutrophils and claimed to constitute a new microbicidal mechanism. Killing by NET-forming cells is ascribed to these structures because it is pr... Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium [作者：Zennadi, R; Whalen, EJ; Soderblom, EJ; Alexander, SC; Thompson, JW; Dubois, LG; Moseley, MA; Telen, MJ,期刊：Blood, 页码：1217-1227 , 文章类型： Article，,卷期：2012年119-5] The core pathology of sickle cell disease (SCD) starts with the erythrocyte (RBC). Aberration in MAPK/ERK1/2 signaling, which can regulate cell adhesion, occurs in diverse pathologies. Because RBCs contain abundant ERK1/... Contrasting dynamic responses in vivo of the Bcl-x(L) and Bim erythropoietic survival pathways [作者：Koulnis, M; Porpiglia, E; Porpiglia, PA; Liu, Y; Hallstrom, K; Hidalgo, D; Socolovsky, M,期刊：Blood, 页码：1228-1239 , 文章类型： Article，,卷期：2012年119-5] Survival signaling by the erythropoietin (Epo) receptor (EpoR) is essential for erythropoiesis and for its acceleration in hypoxic stress. Several apparently redundant EpoR survival pathways were identified in vitro, rai... Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine [作者：Lavelle, D; Vaitkus, K; Ling, YH; Ruiz, MA; Mahfouz, R; Ng, KP; Negrotto, S; Smith, N; Terse, P; Engelke, KJ; Covey, J; Chan, KK; DeSimone, J; Saunthararajah, Y,期刊：Blood, 页码：1240-1247 , 文章类型： Article，,卷期：2012年119-5] The deoxycytidine analog decitabine (DAC) can deplete DNA methyl-transferase 1 (DNMT1) and thereby modify cellular epigenetics, gene expression, and differentiation. However, a barrier to efficacious and accessible DNMT1... Heparin-induced thrombocytopenia: in vitro studies on the interaction of dabigatran, rivaroxaban, and low-sulfated heparin, with platelet factor 4 and anti-PF4/heparin antibodies [作者：Krauel, K; Hackbarth, C; Furll, B; Greinacher, A,期刊：Blood, 页码：1248-1255 , 文章类型： Article，,卷期：2012年119-5] Heparin is a widely used anticoagulant. Because of its negative charge, it forms complexes with positively charged platelet factor 4 (PF4). This can induce anti-PF4/heparin IgG Abs. Resulting immune complexes activate pl... TFPI beta is the GPI-anchored TFPI isoform on human endothelial cells and placental microsomes [作者：Girard, TJ; Tuley, E; Broze, GJ,期刊：Blood, 页码：1256-1262 , 文章类型： Article，,卷期：2012年119-5] Tissue factor pathway inhibitor (TFPI) produces factor Xa-dependent feedback inhibition of factor VIIa/tissue factor-induced coagulation. Messages for 2 isoforms of TFPI have been identified. TFPI alpha mRNA encodes a pr... Desialylation accelerates platelet clearance after refrigeration and initiates GPIb alpha metalloproteinase-mediated cleavage in mice [作者：Jansen, AJG; Josefsson, EC; Rumjantseva, V; Liu, QP; Falet, H; Bergmeier, W; Cifuni, SM; Sackstein, R; von Andrian, UH; Wagner, DD; Hartwig, JH; Hoffmeister, KM,期刊：Blood, 页码：1263-1273 , 文章类型： Article，,卷期：2012年119-5] When refrigerated platelets are rewarmed, they secrete active sialidases, including the lysosomal sialidase Neu1, and express surface Neu3 that remove sialic acid from platelet von Willebrand factor receptor (VWFR), spec... Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells [作者：He, S; Wang, JN; Kato, K; Xie, F; Varambally, S; Mineishi, S; Kuick, R; Mochizuki, K; Liu, YNA; Nieves, E; Mani, RS; Chinnaiyan, AM; Marquez, VE; Zhang, Y,期刊：Blood, 页码：1274-1282 , 文章类型： Article，,卷期：2012年119-5] Histone methylation is thought to be important for regulating Ag-driven T-cell responses. However, little is known about the effect of modulating histone methylation on inflammatory T-cell responses. We demonstrate that ...