- Antibody-dependent anti-cytomegalovirus activity of human gamma delta T cells expressing CD16 (Fc gamma RIIIa)
[作者：Couzi, L; Pitard, V; Sicard, X; Garrigue, I; Hawchar, O; Merville, P; Moreau, JF; Dechanet-Merville, J,期刊：Blood, 页码：1418-1427 , 文章类型： Article，,卷期：2012年119-6]
- Human cytomegalovirus (HCMV) infection is an important cause of morbidity and mortality in transplant recipients. Long-term protective immunity against HCMV requires both sustained specific T-cell response and neutralizi...
- Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID
[作者：Sauer, AV; Brigida, I; Carriglio, N; Hernandez, RJ; Scaramuzza, S; Clavenna, D; Sanvito, F; Poliani, PL; Gagliani, N; Carlucci, F; Tabucchi, A; Roncarolo, MG; Traggiai, E; Villa, A; Aiuti, A,期刊：Blood, 页码：1428-1439 , 文章类型： Article，,卷期：2012年119-6]
- Adenosine acts as anti-inflammatory mediator on the immune system and has been described in regulatory T cell (Treg)-mediated suppression. In the absence of adenosine deaminase (ADA), adenosine and other purine metabolit...
- BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation
[作者：Wensveen, FM; Derks, IAM; van Gisbergen, KPJM; de Bruin, AM; Meijers, JCM; Yigittop, H; Nolte, MA; Eldering, E; van Lier, RAW,期刊：Blood, 页码：1440-1449 , 文章类型： Article，,卷期：2012年119-6]
- The efficiency of humoral immune responses depends on the selective outgrowth of B cells and plasmacells that produce high affinity antibodies. The factors responsible for affinity maturation of B cell clones in the germ...
- KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells
[作者：Mannava, S; Zhuang, DZ; Nair, JR; Bansal, R; Wawrzyniak, JA; Zucker, SN; Fink, EE; Moparthy, KC; Hu, Q; Liu, S; Boise, LH; Lee, KP; Nikiforov, MA,期刊：Blood, 页码：1450-1458 , 文章类型： Article，,卷期：2012年119-6]
- Bortezomib, a therapeutic agent for multiple myeloma (MM) and mantle cell lymphoma, suppresses proteosomal degradation leading to substantial changes in cellular transcriptional programs and ultimately resulting in apopt...
- Partial plasma cell differentiation as a mechanism of lost major histocompatibility complex class II expression in diffuse large B-cell lymphoma
[作者：Wilkinson, ST; Vanpatten, KA; Fernandez, DR; Brunhoeber, P; Garsha, KE; Glinsmann-Gibson, BJ; Grogan, TM; Teruya-Feldstein, J; Rimsza, LM,期刊：Blood, 页码：1459-1467 , 文章类型： Article，,卷期：2012年119-6]
- Loss of major histocompatibility complex class II (MHC II) expression is associated with poor patient outcome in diffuse large B-cell lymphoma (DLBCL). As MHC II molecules are lost with plasmacytic differentiation in nor...
- P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment
[作者：Azab, AK; Quang, P; Azab, F; Pitsillides, C; Thompson, B; Chonghaile, T; Patton, JT; Maiso, P; Monrose, V; Sacco, A; Ngo, HT; Flores, LM; Lin, CP; Magnani, JL; Kung, AL; Letai, A; Carrasco, R; Roccaro, AM; Ghobrial, IM,期刊：Blood, 页码：1468-1478 , 文章类型： Article，,卷期：2012年119-6]
- Interactions between multiple myeloma (MM) cells and the BM microenvironment play a critical role in the pathogenesis of MM and in the development of drug resistance by MM cells. Selectins are involved in extravasation a...
- High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas
[作者：Zocchi, MR; Catellani, S; Canevali, P; Tavella, S; Garuti, A; Villaggio, B; Zunino, A; Gobbi, M; Fraternali-Orcioni, G; Kunkl, A; Ravetti, JL; Boero, S; Musso, A; Poggi, A,期刊：Blood, 页码：1479-1489 , 文章类型： Article，,卷期：2012年119-6]
- Herein we describe that in classic Hodgkin lymphomas (cHL, n = 25) the lymph node (LN) stroma displayed in situ high levels of transcription and expression of the disulfide-isomerase ERp5 and of the disintegrin-metallopr...
- Mitochondrial dysfunction in ataxia-telangiectasia
[作者：Valentin-Vega, YA; MacLean, KH; Tait-Mulder, J; Milasta, S; Steeves, M; Dorsey, FC; Cleveland, JL; Green, DR; Kastan, MB,期刊：Blood, 页码：1490-1500 , 文章类型： Article，,卷期：2012年119-6]
- Ataxia-telangiectasia mutated (ATM) plays a central role in DNA damage responses, and its loss leads to development of T-cell malignancies. Here, we show that ATM loss also leads to intrinsic mitochondrial abnormalities ...
- Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival
[作者：Hamilton, A; Helgason, GV; Schemionek, M; Zhang, B; Myssina, S; Allan, EK; Nicolini, FE; Muller-Tidow, C; Bhatia, R; Brunton, VG; Koschmieder, S; Holyoake, TL,期刊：Blood, 页码：1501-1510 , 文章类型： Article，,卷期：2012年119-6]
- Recent evidence suggests chronic myeloid leukemia (CML) stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated patients. We investigated whether CML stem cells, in a trans...
- KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice
[作者：Zhao, L; Melenhorst, JJ; Alemu, L; Kirby, M; Anderson, S; Kench, M; Hoogstraten-Miller, S; Brinster, L; Kamikubo, Y; Gilliland, DG; Liu, PP,期刊：Blood, 页码：1511-1521 , 文章类型： Article，,卷期：2012年119-6]
- KIT mutations are the most common secondary mutations in inv(16) acute myeloid leukemia (AML) patients and are associated with poor prognosis. It is therefore important to verify that KIT mutations cooperate with CBFB-MY...
- Distinct classes of c-Kit-activating mutations differ in their ability to promote RUNX1-ETO-associated acute myeloid leukemia
[作者：Nick, HJ; Kim, HG; Chang, CW; Harris, KW; Reddy, V; Klug, CA,期刊：Blood, 页码：1522-1531 , 文章类型： Article，,卷期：2012年119-6]
- The t(8; 21) RUNX1-ETO translocation is one of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML). In RUNX1-ETO+ patient samples, differing classes of activating c-KIT receptor tyrosine kinase mu...
- Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes
[作者：Frisan, E; Vandekerckhove, J; de Thonel, A; Pierre-Eugene, C; Sternberg, A; Arlet, JB; Floquet, C; Gyan, E; Kosmider, O; Dreyfus, F; Gabet, AS; Courtois, G; Vyas, P; Ribeil, JA; Zermati, Y; Lacombe, C; Mayeux, P; Solary, E; Garrido, C; Hermine, O; Fontenay, M,期刊：Blood, 页码：1532-1542 , 文章类型： Article，,卷期：2012年119-6]
- Normal human erythroid cell maturation requests the transcription factor GATA-1 and a transient activation of caspase-3, with GATA-1 being protected from caspase-3-mediated cleavage by interaction with the chaperone heat...
- IFN gamma induces monopoiesis and inhibits neutrophil development during inflammation
[作者：de Bruin, AM; Libregts, SF; Valkhof, M; Boon, L; Touw, IP; Nolte, MA,期刊：Blood, 页码：1543-1554 , 文章类型： Article，,卷期：2012年119-6]
- Steady-state hematopoiesis is altered on infection, but the cellular and molecular mechanisms driving these changes are largely unknown. Modulation of hematopoiesis is essential to increase the output of the appropriate ...
- High VWF, low ADAMTS13, and oral contraceptives increase the risk of ischemic stroke and myocardial infarction in young women
[作者：Andersson, HM; Siegerink, B; Luken, BM; Crawley, JTB; Algra, A; Lane, DA; Rosendaal, FR,期刊：Blood, 页码：1555-1560 , 文章类型： Article，,卷期：2012年119-6]
- VWF and ADAMTS13 are major determinants of platelet adhesion after vessel injury. In the present study, we aimed to determine whether VWF or ADAMTS13 plasma antigen levels influence the risks of ischemic stroke (IS) or m...
- Thigh-length versus below-knee compression elastic stockings for prevention of the postthrombotic syndrome in patients with proximal-venous thrombosis: a randomized trial
[作者：Prandoni, P; Noventa, F; Quintavalla, R; Bova, C; Cosmi, B; Siragusa, S; Bucherini, E; Astorri, F; Cuppini, S; Dalla Valle, F; Lensing, AWA; Prins, MH; Villalta, S,期刊：Blood, 页码：1561-1565 , 文章类型： Article，,卷期：2012年119-6]
- Although below-knee compression elastic stockings (CES) are effective for the prevention of the postthrombotic syndrome (PTS), a substantial number of patients with deep venous thrombosis still develop PTS. In the presen...
- Transfusion in the absence of inflammation induces antigen-specific tolerance to murine RBCs
[作者：Smith, NH; Hod, EA; Spitalnik, SL; Zimring, JC; Hendrickson, JE,期刊：Blood, 页码：1566-1569 , 文章类型： Article，,卷期：2012年119-6]
- Most human transfusion recipients fail to make detectable alloantibodies to foreign RBC antigens ("nonresponders"). Herein, we use a murine model to test the hypothesis that nonresponders may be immuno-logically tolerant...
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