- Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment
[作者：D'Souza, S; Kurihara, N; Shiozawa, Y; Joseph, J; Taichman, R; Galson, DL; Roodman, GD,期刊：Blood, 页码：1888-1896 , 文章类型： Article，,卷期：2012年119-8]
- Multiple myeloma (MM) is an incurable B-cell malignancy in which the marrow microenvironment plays a critical role in our inability to cure MM. Marrow stromal cells in the microenvironment support homing, lodging, and gr...
- PI3K delta inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma
[作者：Meadows, SA; Vega, F; Kashishian, A; Johnson, D; Diehl, V; Miller, LL; Younes, A; Lannutti, BJ,期刊：Blood, 页码：1897-1900 , 文章类型： Article，,卷期：2012年119-8]
- GS-1101 (CAL-101) is an oral PI3K delta-specific inhibitor that has shown preclinical and clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. To investigate the potential role of PI3K delta in Hod...
- IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma
[作者：Cairns, RA; Iqbal, J; Lemonnier, F; Kucuk, C; de Leval, L; Jais, JP; Parrens, M; Martin, A; Xerri, L; Brousset, P; Chan, LC; Chan, WC; Gaulard, P; Mak, TW,期刊：Blood, 页码：1901-1903 , 文章类型： Article，,卷期：2012年119-8]
- Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) occur in most grade 2 and 3 gliomas, secondary glioblastomas, and a subset of acute myelogenous leukemias but have not been detected in...
- Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
[作者：Yuan, HF; Wang, ZQ; Li, L; Zhang, H; Modi, H; Horne, D; Bhatia, R; Chen, WY,期刊：Blood, 页码：1904-1914 , 文章类型： Article，,卷期：2012年119-8]
- The tyrosine kinase inhibitor imatinib is highly effective in the treatment of chronic myelogenous leukemia (CML), but primary and acquired resistance of CML cells to the drug offset its efficacy. Molecular mechanisms fo...
- Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin
[作者：Lebensburger, JD; Howard, T; Hu, YM; Pestina, TI; Gao, GL; Johnson, M; Zakharenko, SS; Ware, RE; Tuomanen, EI; Persons, DA; Rosch, JW,期刊：Blood, 页码：1915-1921 , 文章类型： Article，,卷期：2012年119-8]
- Sickle cell anemia is characterized by chronic hemolysis coupled with extensive vascular inflammation. This inflammatory state also mechanistically promotes a high risk of lethal, invasive pneumococcal infection. Current...
- Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children
[作者：Prentice, AM; Doherty, CP; Abrams, SA; Cox, SE; Atkinson, SH; Verhoef, H; Armitage, AE; Drakesmith, H,期刊：Blood, 页码：1922-1928 , 文章类型： Article，,卷期：2012年119-8]
- Iron supplementation strategies in the developing world remain controversial because of fears of exacerbating prevalent infectious diseases. Understanding the conditions in which iron will be absorbed and incorporated in...
- Influence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: the ARIC Study
[作者：Campos, M; Buchanan, A; Yu, FL; Barbalic, M; Xiao, Y; Chambless, LE; Wu, KK; Folsom, AR; Boerwinkle, E; Dong, JF,期刊：Blood, 页码：1929-1934 , 文章类型： Article，,卷期：2012年119-8]
- Factor VIII (FVIII) functions as a cofactor for factor IXa in the contact coagulation pathway and circulates in a protective complex with von Willebrand factor (VWF). Plasma FVIII activity is strongly influenced by envir...
- Anewly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling
[作者：Ma, PS; Cierniewska, A; Signarvic, R; Cieslak, M; Kong, H; Sinnamon, AJ; Neubig, RR; Newman, DK; Stalker, TJ; Brass, LF,期刊：Blood, 页码：1935-1945 , 文章类型： Article，,卷期：2012年119-8]
- Platelets are essential for normal hemostasis, but close regulation is required to avoid the destructive effects of either inappropriate platelet activation or excessive responses to injury. Here, we describe a novel com...
- The adaptor protein Shc integrates growth factor and ECM signaling during postnatal angiogenesis
[作者：Sweet, DT; Chen, ZM; Wiley, DM; Bautch, VL; Tzima, E,期刊：Blood, 页码：1946-1955 , 文章类型： Article，,卷期：2012年119-8]
- Angiogenesis requires integration of cues from growth factors, extracellular matrix (ECM) proteins, and their receptors in endothelial cells. In the present study, we show that the adaptor protein Shc is required for ang...
- In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling
[作者：Nishimura, S; Manabe, I; Nagasaki, M; Kakuta, S; Iwakura, Y; Takayama, N; Ooehara, J; Otsu, M; Kamiya, A; Petrich, BG; Urano, T; Kadono, T; Sato, S; Aiba, A; Yamashita, H; Sugiura, S; Kadowaki, T; Nakauchi, H; Eto, K; Nagai, R,期刊：Blood, 页码：E45-E56 , 文章类型： Article，,卷期：2012年119-8]
- The mechanism by which thrombotic vessel occlusion occurs independently of plaque development or endothelial cell (EC) disruption remains unclear, largely because of an inability to visualize the formation of thrombus, e...
- A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy
[作者：Canavan, JB; Afzali, B; Scotta, C; Fazekasova, H; Edozie, FC; Macdonald, TT; Hernandez-Fuentes, MP; Lombardi, G; Lord, GM,期刊：Blood, 页码：E57-E66 , 文章类型： Article，,卷期：2012年119-8]
- Regulatory T cells (CD4(+)CD25(hi)CD127(lo)-FOXP3(+) T cells [Tregs]) are a population of lymphocytes involved in the maintenance of self-tolerance. Abnormalities in function or number of Tregs are a feature of autoimmun...
- Emerging roles for multipotent, bone marrow-derived stromal cells in host defense
[作者：Auletta, JJ; Deans, RJ; Bartholomew, AM,期刊：Blood, 页码：1801-1809 , 文章类型： Article，,卷期：2012年119-8]
- Multipotent, bone marrow-derived stromal cells (BMSCs, also known as mesenchymal stem cells [MSCs]), are culture-expanded, nonhematopoietic cells with immunomodulatory effects currently being investigated as novel cellul...
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