个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共35条记录   LYMPHOID NEOPLASIA Taking it up a notch in MCL [作者：Parekh, S,期刊：Blood, 页码：1957-1958 , 文章类型： Editorial Material，,卷期：2012年119-9] In this issue of Blood, Kridel et al describe recurrent NOTCH1 mutations in mantle cell lymphoma (MCL) by next-generation sequencing of patient samples and cell lines. They further demonstrate a negative prognostic impac... MYELOID NEOPLASIA Unveiling the complexity of CK plus AML [作者：Medeiros, BC,期刊：Blood, 页码：1958-1959 , 文章类型： Editorial Material，,卷期：2012年119-9] In acute myeloid leukemia (AML), cytogenetic abnormalities are present in more than half of patients and these chromosomal alterations are critical factors that determine response to chemotherapy and survival.(1,2) THROMBOSIS & HEMOSTASIS VWF sequence variants: innocent until proven guilty [作者：Babushok, D; Cuker, A,期刊：Blood, 页码：1959-1960 , 文章类型： Editorial Material，,卷期：2012年119-9] William James, the 19th century American philosopher, famously asserted, "To study the abnormal is the best way of understanding the normal." In this issue of Blood, using a distinctly non-Jamesian approach, Bellissimo a... Aleukemic variant of mast cell leukemia [作者：Zeerleder, S; van Oers, M,期刊：Blood, 页码：1961-1961 , 文章类型： Editorial Material，,卷期：2012年119-9] Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma [作者：Kridel, R; Meissner, B; Rogic, S; Boyle, M; Telenius, A; Woolcock, B; Gunawardana, J; Jenkins, C; Cochrane, C; Ben-Neriah, S; Tan, K; Morin, RD; Opat, S; Sehn, LH; Connors, JM; Marra, MA; Weng, AP; Steidl, C; Gascoyne, RD,期刊：Blood, 页码：1963-1971 , 文章类型： Article，,卷期：2012年119-9] Mantle cell lymphoma (MCL), an aggressive subtype of non-Hodgkin lymphoma, is characterized by the hallmark translocation t(11;14)(q13;q32) and the resulting overexpression of cyclin D1 (CCND1). Our current knowledge of ... Selection of optimal alternative graft source: mismatched unrelated donor, umbilical cord blood, or haploidentical transplant [作者：Ballen, KK; Koreth, J; Chen, YB; Dey, BR; Spitzer, TR,期刊：Blood, 页码：1972-1980 , 文章类型： Review，,卷期：2012年119-9] Only 30% of patients who require an allogeneic hematopoietic cell transplant will have an HLA-matched sibling donor. A search for an unrelated donor will be undertaken for patients without a matched family donor. However... Improved survival in chronic myeloid leukemia since the introduction of imatinib therapy: a single-institution historical experience [作者：Kantarjian, H; O'Brien, S; Jabbour, E; Garcia-Manero, G; Quintas-Cardama, A; Shan, J; Rios, MB; Ravandi, F; Faderl, S; Kadia, T; Borthakur, G; Huang, XL; Champlin, R; Talpaz, M; Cortes, J,期刊：Blood, 页码：1981-1987 , 文章类型： Article，,卷期：2012年119-9] A total of 1569 patients with chronic myeloid leukemia (CML) referred to our institution within 1 month of diagnosis since 1965 were reviewed: 1148 chronic phase (CP), 175 accelerated phase (AP), and 246 blastic phase (B... Fludarabine and rituximab for relapsed or refractory hairy cell leukemia [作者：Gerrie, AS; Zypchen, LN; Connors, JM,期刊：Blood, 页码：1988-1991 , 文章类型： Article，,卷期：2012年119-9] The purine analogs, pentostatin and cladribine, induce high remission rates when used as first-line monotherapy for hairy cell leukemia (HCL); however, patients continue to relapse. Re-treatment with the same or alternat... p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC-and FANCA-deficient mononuclear phagocytes [作者：Anur, P; Yates, J; Garbati, MR; Vanderwerf, S; Keeble, W; Rathbun, K; Hays, LE; Tyner, JW; Svahn, J; Cappelli, E; Dufour, C; Bagby, GC,期刊：Blood, 页码：1992-2002 , 文章类型： Article，,卷期：2012年119-9] Fanconi anemia, complementation group C (FANCC)-deficient hematopoietic stem and progenitor cells are hypersensitive to a variety of inhibitory cytokines, one of which, TNF alpha, can induce BM failure and clonal evoluti... IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors [作者：Becker, AM; Michael, DG; Satpathy, AT; Sciammas, R; Singh, H; Bhattacharya, D,期刊：Blood, 页码：2003-2012 , 文章类型： Article，,卷期：2012年119-9] While most blood lineages are assumed to mature through a single cellular and developmental route downstream of HSCs, dendritic cells (DCs) can be derived from both myeloid and lymphoid progenitors in vivo. To determine ... HIV-1 envelope-dependent restriction of CXCR4-using viruses in child but not adult untransformed CD4(+) T-lymphocyte lines [作者：Mariani, SA; Brigida, I; Kajaste-Rudnitski, A; Ghezzi, S; Rocchi, A; Plebani, A; Vicenzi, E; Aiuti, A; Poli, G,期刊：Blood, 页码：2013-2023 , 文章类型： Article，,卷期：2012年119-9] Phytohemagglutin-stimulated child and adult leukocytes equally supported CCR5-dependent (R5) and CXCR4-dependent (X4) HIV-1 replication. In contrast, when phytohemagglutin-stimulated leukocytes from either healthy or con... Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection [作者：Zoughlami, Y; Voermans, C; Brussen, K; van Dort, KA; Kootstra, NA; Maussang, D; Smit, MJ; Hordijk, PL; van Hennik, PB,期刊：Blood, 页码：2024-2032 , 文章类型： Article，,卷期：2012年119-9] The chemokine receptor CXCR4 is a critical regulator of cell migration and serves as a coreceptor for HIV-1. The chemokine stromal cell derived factor-1, also known as CXCL12, binds to CXCR4 and exerts its biologic funct... Functional characterization of CD4(+) T cells in aplastic anemia [作者：Kordasti, S; Marsh, J; Al-Khan, S; Jiang, J; Smith, A; Mohamedali, A; Abellan, PP; Veen, C; Costantini, B; Kulasekararaj, AG; Benson-Quarm, N; Seidl, T; Mian, SA; Farzaneh, F; Mufti, GJ,期刊：Blood, 页码：2033-2043 , 文章类型： Article，,卷期：2012年119-9] The role of CD4(+) T cells in the pathogenesis of aplastic anemia (AA) is not well characterized. We investigate CD4(+) T-cell subsets in AA. Sixty-three patients with acquired AA were studied. Th1 and Th2 cells were sig... Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates [作者：Kwissa, M; Nakaya, HI; Oluoch, H; Pulendran, B,期刊：Blood, 页码：2044-2055 , 文章类型： Article，,卷期：2012年119-9] TLR ligands (TLR-Ls) represent novel vaccine adjuvants, but their immunologic effects in humans remain poorly defined in vivo. In the present study, we analyzed the innate responses stimulated by different TLR-Ls in rhes... Conjugation of lymphoma idiotype to CD40 antibody enhances lymphoma vaccine immunogenicity and antitumor effects in mice [作者：Carlring, J; Szabo, MJ; Dickinson, R; De Leenheer, E; Heath, AW,期刊：Blood, 页码：2056-2065 , 文章类型： Article，,卷期：2012年119-9] Personalized immunotherapy of lymphoma based on tumor idiotype (Id) has shown anti-idiotype humoral immune responses in 40%-50% and cellular immune responses in 50%-75% of follicular lymphoma patients, indicating that th... Interim 18-FDG-PET/CT failed to predict the outcome in diffuse large B-cell lymphoma patients treated at the diagnosis with rituximab-CHOP [作者：Pregno, P; Chiappella, A; Bello, M; Botto, B; Ferrero, S; Franceschetti, S; Giunta, F; Ladetto, M; Limerutti, G; Menga, M; Nicolosi, M; Priolo, G; Puccini, B; Rigacci, L; Salvi, F; Vaggelli, L; Passera, R; Bisi, G; Vitolo, U,期刊：Blood, 页码：2066-2073 , 文章类型： Article，,卷期：2012年119-9] Role of interim-PET (I-PET) in diffuse large B-cell Lymphoma (DLBCL) is controversial. To determine predictive value of I-PET on progression-free survival (PFS), we enrolled 88 first-line DLBCL patients treated with 6-8 ...