- Brief report Chromosome aberrations detected by conventional karyotyping using novel mitogens in chronic lymphocytic leukemia with "normal" FISH: correlations with clinicobiologic parameters
[作者：Rigolin, GM; Cibien, F; Martinelli, S; Formigaro, L; Rizzotto, L; Tammiso, E; Saccenti, E; Bardi, A; Cavazzini, F; Ciccone, M; Nichele, I; Pizzolo, G; Zaja, F; Fanin, R; Galieni, P; Dalsass, A; Mestichelli, F; Testa, N; Negrini, M; Cuneo, A,期刊：Blood, 页码：2310-2313 , 文章类型： Article，,卷期：2012年119-10]
- It is unclear whether karyotype aberrations that occur in regions uncovered by the standard fluorescence in situ hybridization (FISH) panel have prognostic relevance in chronic lymphocytic leukemia (CLL). We evaluated th...
- Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML
[作者：Li, ZJ; Huang, H; Li, YY; Jiang, X; Chen, P; Arnovitz, S; Radmacher, MD; Maharry, K; Elkahloun, A; Yang, XN; He, CJ; He, M; Zhang, ZY; Dohner, K; Neilly, MB; Price, C; Lussier, YA; Zhang, YM; Larson, RA; Le Beau, MM; Caligiuri, MA; Bullinger, L; Valk, PJM; Delwel, R; Lowenberg, B; Liu, PP; Marcucci, G; Bloomfield, CD; Rowley, JD; Chen, JJ,期刊：Blood, 页码：2314-2324 , 文章类型： Article，,卷期：2012年119-10]
- Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-...
- Phagocytosis by macrophages and endothelial cells inhibits procoagulant and fibrinolytic activity of acute promyelocytic leukemia cells
[作者：Xie, R; Gao, CY; Li, W; Zhu, JX; Novakovic, V; Wang, J; Ma, RS; Zhou, J; Gilbert, GE; Shi, JL,期刊：Blood, 页码：2325-2334 , 文章类型： Article，,卷期：2012年119-10]
- The coagulopathy of acute promyelocytic leukemia (APL) is mainly related to procoagulant substances and fibrinolytic activators of APL blasts, but the fate of these leukemic cells is unknown. The aim of this study was to...
- Targeting of GSK3 beta promotes imatinib-mediated apoptosis in quiescent CD34(+) chronic myeloid leukemia progenitors, preserving normal stem cells
[作者：Reddiconto, G; Toto, C; Palama, I; De Leo, S; de Luca, E; De Matteis, S; Dini, L; Passerini, CG; Di Renzo, N; Maffia, M; Coluccia, AML,期刊：Blood, 页码：2335-2345 , 文章类型： Article，,卷期：2012年119-10]
- The targeting of BCR-ABL, a hybrid oncogenic tyrosine (Y) kinase, does not eradicate chronic myeloid leukemia (CML)-initiating cells. Activation of beta-catenin was linked to CML leukemogenesis and drug resistance throug...
- Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene
[作者：Agrawal-Singh, S; Isken, F; Agelopoulos, K; Klein, HU; Thoennissen, NH; Koehler, G; Hascher, A; Baumer, N; Berdel, WE; Thiede, C; Ehninger, G; Becker, A; Schlenke, P; Wang, YP; McClelland, M; Krug, U; Koschmieder, S; Buchner, T; Yu, DY; Singh, SV; Hansen, K; Serve, H; Dugas, M; Muller-Tidow, C,期刊：Blood, 页码：2346-2357 , 文章类型： Article，,卷期：2012年119-10]
- With the use of ChIP on microarray assays in primary leukemia samples, we report that acute myeloid leukemia (AML) blasts exhibit significant alterations in histone H3 acetylation (H3Ac) levels at > 1000 genomic loci com...
- Prostaglandin E-2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling
[作者：Zaslona, Z; Serezani, CH; Okunishi, K; Aronoff, DM; Peters-Golden, M,期刊：Blood, 页码：2358-2367 , 文章类型： Article，,卷期：2012年119-10]
- Prostaglandin E-2 (PGE(2)) is a lipid mediator that acts by ligating 4 distinct G protein-coupled receptors, E prostanoid (EP) 1 to 4. Previous studies identified the importance of PGE(2) in regulating macrophage functio...
- Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production
[作者：Fortes, GB; Alves, LS; de Oliveira, R; Dutra, FF; Rodrigues, D; Fernandez, PL; Souto-Padron, T; De Rosa, MJ; Kelliher, M; Golenbock, D; Chan, FKM; Bozza, MT,期刊：Blood, 页码：2368-2375 , 文章类型： Article，,卷期：2012年119-10]
- Diseases that cause hemolysis or myonecrosis lead to the leakage of large amounts of heme proteins. Free heme has proinflammatory and cytotoxic effects. Heme induces TLR4-dependent production of tumor necrosis factor (TN...
- Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia
[作者：Kuramitsu, M; Sato-Otsubo, A; Morio, T; Takagi, M; Toki, T; Terui, K; Wang, RN; Kanno, H; Ohga, S; Ohara, A; Kojima, S; Kitoh, T; Goi, K; Kudo, K; Matsubayashi, T; Mizue, N; Ozeki, M; Masumi, A; Momose, H; Takizawa, K; Mizukami, T; Yamaguchi, K; Ogawa, S; Ito, E; Hamaguchi, I,期刊：Blood, 页码：2376-2384 , 文章类型： Article，,卷期：2012年119-10]
- Fifty percent of Diamond-Blackfan anemia (DBA) patients possess mutations in genes coding for ribosomal proteins (RPs). To identify new mutations, we investigated large deletions in the RP genes RPL5, RPL11, RPL35A, RPS7...
- ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice
[作者：Gandhi, C; Khan, MM; Lentz, SR; Chauhan, AK,期刊：Blood, 页码：2385-2391 , 文章类型： Article，,卷期：2012年119-10]
- ADAMTS13, a metalloprotease, plays a pivotal role in preventing spontaneous microvascular thrombosis by cleaving hyperactive ultra large von Willebrand factor multimers into smaller, less active multimers. Reduced ADAMTS...
- The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies
[作者：Dennis, J; Johnson, CY; Adediran, AS; de Andrade, M; Heit, JA; Morange, PE; Tregouet, DA; Gagnon, F,期刊：Blood, 页码：2392-2400 , 文章类型： Review，,卷期：2012年119-10]
- The endothelial protein C receptor (EPCR) limits thrombus formation by enhancing activation of the protein C anticoagulant pathway, and therefore may play a role in the etiology of thrombotic disorders. The rs867186 sing...
- Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys
[作者：Younis, HS; Crosby, J; Huh, JI; Lee, HS; Rime, S; Monia, B; Henry, SP,期刊：Blood, 页码：2401-2408 , 文章类型： Article，,卷期：2012年119-10]
- A strategy to produce sufficient anticoagulant properties with reduced risk of bleeding may be possible through inhibition of factor XI (FXI), a component of the intrinsic coagulation cascade. The objective of this work ...
- Related transplantation with HLA-1 Ag mismatch in the GVH direction and HLA-8/8 allele-matched unrelated transplantation: a nationwide retrospective study
[作者：Kanda, J; Saji, H; Fukuda, T; Kobayashi, T; Miyamura, K; Eto, T; Kurokawa, M; Kanamori, H; Mori, T; Hidaka, M; Iwato, K; Yoshida, T; Sakamaki, H; Tanaka, J; Kawa, K; Morishima, Y; Suzuki, R; Atsuta, Y; Kanda, Y,期刊：Blood, 页码：2409-2416 , 文章类型： Article，,卷期：2012年119-10]
- To clarify which is preferable, a related donor with an HLA-1 Ag mismatch at the HLA-A, HLA-B, or HLA-DR loci in the graft-versus-host (GVH) direction (RD/1AG-MM-GVH) or an HLA 8/8-allele (HLA-A, HLA-B, HLA-C, and HLA-DR...
- Predicting posttransplantation diabetes mellitus by regulatory T-cell phenotype: implications for metabolic intervention to modulate alloreactivity
[作者：Engelhardt, BG; Jagasia, SM; Crowe, JE; Griffith, ML; Savani, BN; Kassim, AA; Lu, PC; Weitkamp, JH; Moore, DJ; Yoder, SM; Rock, MT; Jagasia, M,期刊：Blood, 页码：2417-2421 , 文章类型： Article，,卷期：2012年119-10]
- Chronic inflammation and decreased frequency of regulatory T cells (Tregs) in visceral adipose tissue contribute to the propagation of insulin resistance to diabetes mellitus. We tested the hypothesis that new-onset post...
- e-Blood High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations
[作者：Kuhn, MWM; Radtke, I; Bullinger, L; Goorha, S; Cheng, JJ; Edelmann, J; Gohlke, J; Su, XP; Paschka, P; Pounds, S; Krauter, J; Ganser, A; Quessar, A; Ribeiro, R; Gaidzik, VI; Shurtleff, S; Kronke, J; Holzmann, K; Ma, J; Schlenk, RF; Rubnitz, JE; Dohner, K; Dohner, H; Downing, JR,期刊：Blood, 页码：E67-E75 , 文章类型： Editorial Material，,卷期：2012年119-10]
- To identify cooperating lesions in core-binding factor acute myeloid leukemia, we performed single-nucleotide polymorphism-array analysis on 300 diagnostic and 41 relapse adult and pediatric leukemia samples. We identifi...
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