- Ultrasensitive in situ visualization of active glucocerebrosidase molecules
[作者:WITTE MARTIN D; KALLEMEIJN WOUTER W; ATEN JAN; LI KAHYEE; STRIJLAND ANNEKE; DONKERKOOPMAN WILMA E; VAN DEN NIEUWENDIJK ADRIANUS M C H; BLEIJLEVENS BORIS; KRAMER GERTJAN; FLOREA BOGDAN I; HOOIBRINK BEREND; HOLLAK CARLA E M; OTTENHOFF ROELOF; BOOT ROLF G; VAN DER MAREL GIJSBERT A; OVERKLEEFT HERMAN S; AERTS JOHANNES M F G,期刊:NATURE CHEMICAL BIOLOGY, 页码:907-913 , 文章类型: Article,,卷期:2010年6-12]
- Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exi...
- RNA epigenetics?
[作者:HE CHUAN,期刊:NATURE CHEMICAL BIOLOGY, 页码:863-865 , 文章类型: Editorial Material,,卷期:2010年6-12]
- Post-transcriptional RNA modifications can be dynamic and might have functions beyond fine-tuning the structure and function of RNA. Understanding these RNA modification pathways and their functions may allow researchers...
- CHAPERONES A story of thrift unfolds
[作者:BANEYX FRANCOIS; NANNENGA BRENT L,期刊:NATURE CHEMICAL BIOLOGY, 页码:880-881 , 文章类型: News Item,,卷期:2010年6-12]
- Although members of the Hsp70-DnaK family of heat shock proteins are involved in nearly all aspects of cell physiology, some mechanistic details of their mode of action remain obscure. A new substrate helps establish Dna...
- MOLECULAR PROBES Getting lucky in the lysosome
[作者:GODDARDBORGER ETHAN D; WENNEKES TOM; WITHERS STEPHEN G,期刊:NATURE CHEMICAL BIOLOGY, 页码:881-883 , 文章类型: News Item,,卷期:2010年6-12]
- Conjugation of a known, mechanism-based glycosidase inhibitor to sensitive fluorophores yielded unexpectedly potent and selective probes for quantifying active lysosomal glucocerebrosidase. These conjugates could prove t...
- GLYCOBIOLOGY Cellulose squeezes through
[作者:ENDLER ANNE; SANCHEZRODRIGUEZ CLARA; PERSSON STAFFAN,期刊:NATURE CHEMICAL BIOLOGY, 页码:883-884 , 文章类型: News Item,,卷期:2010年6-12]
- The glucose-based polymer cellulose is of great biological and economical importance; however, little is known about how cellulose is synthesized. Now, structural estimates of one of the cellulose-synthesizing subunits i...
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