- In vitro reconstruction of tetronate RK-682 biosynthesis
[作者:SUN YUHUI; HAHN FRANK; DEMYDCHUK YULIYA; CHETTLE JAMES; TOSIN MANUELA; OSADA HIROYUKI; LEADLAY PETER F,期刊:NATURE CHEMICAL BIOLOGY, 页码:99-101 , 文章类型: Article,,卷期:2010年6-2]
- The protein phosphatase inhibitor RK-682 is one of a number of potentially valuable tetronate polyketide natural products. Understanding how the tetronate ring is formed has been frustrated by the inaccessibility of the ...
- The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors
[作者:BERNDT ALEX; MILLER SIMON; WILLIAMS OLUSEGUN; LE DANIEL D; HOUSEMAN BENJAMIN T; PACOLD JOSEPH I; GORREC FABRICE; HON WAICHING; LIU YI; ROMMEL CHRISTIAN; GAILLARD PASCALE; RUECKLE THOMAS; SCHWARZ MATTHIAS K; SHOKAT KEVAN M; SHAW JEFFREY P; WILLIAMS ROGER L,期刊:NATURE CHEMICAL BIOLOGY, 页码:117-124 , 文章类型: Article,,卷期:2010年6-2]
- Deregulation of the phosphoinositide-3-OH kinase (PI(3) K) pathway has been implicated in numerous pathologies-including cancer, diabetes, thrombosis, rheumatoid arthritis and asthma. Recently, small-molecule and ATP-com...
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