- Myeloid Leukemia Development in c-Cbl RING Finger Mutant Mice Is Dependent on FLT3 Signaling
[作者：Rathinam, C; Thien, CBF; Flavell, RA; Langdon, WY,期刊：Cancer Cell, 页码：341-352 , 文章类型： Article，,卷期：2010年18-4]
- Although myeloid leukemias are primarily caused by leukemic stem cells, the molecular basis of their transformation remains largely unknown. Here, by analyzing mice with a mutation in the RING finger domain of c-Cbl, we ...
- T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation
[作者：Feng, H; Stachura, DL; White, RM; Gutierrez, A; Zhang, L; Sanda, T; Jette, CA; Testa, JR; Neuberg, DS; Langenau, DM; Kutok, JL; Zon, LI; Traver, D; Fleming, MD; Kanki, JP; Look, AT,期刊：Cancer Cell, 页码：353-366 , 文章类型： Article，,卷期：2010年18-4]
- The molecular events underlying the progression of T-lymphoblastic lymphoma (T-LBL) to acute T-lymphoblastic leukemia (T-ALL) remain elusive. In our zebrafish model, concomitant overexpression of bcl-2 with Myc accelerat...
- Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development
[作者：Pichiorri, F; Suh, SS; Rocci, A; De Luca, L; Taccioli, C; Santhanam, R; Zhou, WC; Benson, DM; Hofmainster, C; Alder, H; Garofalo, M; Di Leva, G; Volinia, S; Lin, HJ; Perrotti, D; Kuehl, M; Aqeilan, RI; Palumbo, A; Croce, CM,期刊：Cancer Cell, 页码：367-381 , 文章类型： Article，,卷期：2010年18-4]
- In multiple myeloma (MM), an incurable B cell neoplasm, mutation or deletion of p53 is rarely detected at diagnosis. Using small-molecule inhibitors of MDM2, we provide evidence that miR-192, 194, and 215, which are down...
- Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage
[作者：Zeng, X; Sigoillot, F; Gaur, S; Choi, S; Pfaff, KL; Oh, DC; Hathaway, N; Dimova, N; Cuny, GD; King, RW,期刊：Cancer Cell, 页码：382-395 , 文章类型： Article，,卷期：2010年18-4]
- Microtubule inhibitors are important cancer drugs that induce mitotic arrest by activating the spindle assembly checkpoint (SAC), which, in turn, inhibits the ubiquitin ligase activity of the anaphase-promoting complex (...
- Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation
[作者：Wilson, BG; Wang, X; Shen, XH; McKenna, ES; Lemieux, ME; Cho, YJ; Koellhoffer, EC; Pomeroy, SL; Orkin, SH; Roberts, CWM,期刊：Cancer Cell, 页码：316-328 , 文章类型： Article，,卷期：2010年18-4]
- Epigenetic alterations have been increasingly implicated in oncogenesis. Analysis of Drosophila mutants suggests that Polycomb and SWI/SNF complexes can serve antagonistic developmental roles. However, the relevance of t...
- Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase
[作者：Aggarwal, P; Vaites, LP; Kim, JK; Mellert, H; Gurung, B; Nakagawa, H; Herlyn, M; Hua, XX; Rustgi, AK; McMahon, SB; Diehl, JA,期刊：Cancer Cell, 页码：329-340 , 文章类型： Article，,卷期：2010年18-4]
- Cyclin D1 elicits transcriptional effects through inactivation of the retinoblastoma protein and direct association with transcriptional regulators. The current work reveals a molecular relationship between cyclin D1/CDK...
- A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells
[作者：Melo, SA; Moutinho, C; Ropero, S; Calin, GA; Rossi, S; Spizzo, R; Fernandez, AF; Davalos, V; Villanueva, A; Montoya, G; Yamamoto, H; Schwartz, S; Esteller, M,期刊：Cancer Cell, 页码：303-315 , 文章类型： Article，,卷期：2010年18-4]
- The global impairment of mature microRNAs (miRNAs) is emerging as a common feature of human tumors. One interesting scenario is that defects in the nuclear export of precursor miRNAs (pre-miRNAs) might occur in transform...
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