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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Pharmacological Rescue of p53 in Cancer Therapy: Widening the Sensitive Tumor Spectrum by Targeting MDMX [作者：Marine, JC,期刊：Cancer Cell, 页码：399-400 , 文章类型： Editorial Material，,卷期：2010年18-5] Targeting p53's main negative regulator MDM2 is a promising strategy for treating cancers that retain wildtype p53. Unfortunately, MDM2 inhibitors are largely ineffective against tumors overexpressing MDMX. In this issue... Unfavorable Drug Interactions in Targeted Breast Cancer Therapy [作者：Groner, B; Hynes, NE,期刊：Cancer Cell, 页码：401-402 , 文章类型： Editorial Material，,卷期：2010年18-5] Trastuzumab is used to treat HER2-positive breast cancer; erythropoietin (EPO) is used to alleviate chemotherapy-associated side effects. In this issue of Cancer Cell, Liang et al. show that many breast tumors express EP... Can Antitumor Immunity Help to Explain "Oncogene Addiction"? [作者：Restifo, NP,期刊：Cancer Cell, 页码：403-405 , 文章类型： Editorial Material，,卷期：2010年18-5] Oncogene addiction refers to the process of tumor cell death that can occur after inactivation of a single oncogene. In this issue of Cancer Cell, Rakhra et al. argue that complete tumor clearance after molecular targete... STATistical Power of Clonal Analysis: Differential STAT1 Pathway Activation Downstream of the JAK2V617F Mutation [作者：Mullally, A; Ebert, BL,期刊：Cancer Cell, 页码：405-406 , 文章类型： Editorial Material，,卷期：2010年18-5] The biological basis of the phenotypic diversity observed in JAK2V617F-positive myeloproliferative neoplasms is poorly understood. In this issue of Cancer Cell, Chen et al. show that interferon and STAT1 signaling are ac... Bioinformatic Mining of Gene Expression Datasets Identifies ETV1 as a Critical Regulator of Oncogenesis in Gastrointestinal Stromal Tumors [作者：Rubin, BP,期刊：Cancer Cell, 页码：407-408 , 文章类型： Editorial Material，,卷期：2010年18-5] KIT mutations are the hallmark of gastrointestinal stromal tumors (GISTs). In a paper recently published in Nature, Sawyers and colleagues demonstrate that ETV1 collaborates with oncogenic KIT to initiate a GIST-specific... An Identity Crisis for a Cancer Gene: Subcellular Location Determines ASPP1 Function [作者：Manfredi, JJ,期刊：Cancer Cell, 页码：409-410 , 文章类型： Editorial Material，,卷期：2010年18-5] Two recent papers in Genes and Development argue that the ASPP1 protein has distinct roles in cell survival, depending upon its subcellular localization, that are determined by a complex interplay with LATS kinase and th... A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53 [作者：Bernal, F; Wade, M; Godes, M; Davis, TN; Whitehead, DG; Kung, AL; Wahl, GM; Walensky, LD,期刊：Cancer Cell, 页码：411-422 , 文章类型： Article，,卷期：2010年18-5] Cancer cells neutralize p53 by deletion, mutation, proteasomal degradation, or sequestration to achieve a pathologic survival advantage. Targeting the E3 ubiquitin ligase HDM2 can lead to a therapeutic surge in p53 level... Recombinant Human Erythropoietin Antagonizes Trastuzumab Treatment of Breast Cancer Cells via Jak2-Mediated Src Activation and PTEN Inactivation [作者：Liang, K; Esteva, FJ; Albarracin, C; Stemke-Hale, K; Lu, Y; Bianchini, G; Yang, CY; Li, Y; Li, XQ; Chen, CT; Mills, GB; Hortobagyi, GN; Mendelsohn, J; Hung, MC; Fan, Z,期刊：Cancer Cell, 页码：423-435 , 文章类型： Article，,卷期：2010年18-5] We found that the receptor for erythropoietin (EpoR) is coexpressed with human epidermal growth factor receptor-2 (HER2) in a significant percentage of human breast tumor specimens and breast cancer cell lines. Exposure ... Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability [作者：Bhaskara, S; Knutson, SK; Jiang, GC; Chandrasekharan, MB; Wilson, AJ; Zheng, SY; Yenamandra, A; Locke, K; Yuan, JL; Bonine-Summers, AR; Wells, CE; Kaiser, JF; Washington, MK; Zhao, ZM; Wagner, FF; Sun, ZW; Xia, F; Holson, EB; Khabele, D; Hiebert, SW,期刊：Cancer Cell, 页码：436-447 , 文章类型： Article，,卷期：2010年18-5] Hdac3 is essential for efficient DNA replication and DNA damage control. Deletion of Hdac3 impaired DNA repair and greatly reduced chromatin compaction and heterochromatin content. These defects corresponded to increases... Oncogenic KRas Suppresses Inflammation-Associated Senescence of Pancreatic Ductal Cells [作者：Lee, KE; Bar-Sagi, D,期刊：Cancer Cell, 页码：448-458 , 文章类型： Article，,卷期：2010年18-5] Mutational activation of KRas is the first and most frequently detected genetic lesion in pancreatic ductal adenocarcinoma (PDAC). However, the precise role of oncogenic KRas in the pathogenesis of PDAC is not fully unde... B55 beta-Associated PP2A Complex Controls PDK1-Directed Myc Signaling and Modulates Rapamycin Sensitivity in Colorectal Cancer [作者：Tan, J; Lee, PL; Li, ZM; Jiang, X; Lim, YC; Hooi, SC; Yu, QA,期刊：Cancer Cell, 页码：459-471 , 文章类型： Article，,卷期：2010年18-5] The PP2A serine/threonine protein phosphatase serves as a critical cellular regulator of cell growth, proliferation, and survival. However, how this pathway is altered in human cancer to confer growth advantage is largel... FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis [作者：Gan, BY; Lim, C; Chu, G; Hua, SJ; Ding, ZH; Collins, M; Hu, JA; Jiang, S; Fletcher-Sananikone, E; Zhuang, L; Chang, M; Zheng, HW; Wang, YA; Kwiatkowski, DJ; Kaelin, WG; Signoretti, S; DePinho, RA,期刊：Cancer Cell, 页码：472-484 , 文章类型： Article，,卷期：2010年18-5] mTORC1 is a validated therapeutic target for renal cell carcinoma (RCC). Here, analysis of Tsc1-deficient (mTORC1 hyperactivation) mice uncovered a FoxO-dependent negative feedback circuit constraining mTORC1-mediated re... CD4(+) T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation [作者：Rakhra, K; Bachireddy, P; Zabuawala, T; Zeiser, R; Xu, LW; Kopelman, A; Fan, AC; Yang, QW; Braunstein, L; Crosby, E; Ryeom, S; Felsher, DW,期刊：Cancer Cell, 页码：485-498 , 文章类型： Article，,卷期：2010年18-5] Oncogene addiction is thought to occur cell autonomously. Immune effectors are implicated in the initiation and restraint of tumorigenesis, but their role in oncogene inactivation-mediated tumor regression is unclear. He... Germline Brca2 Heterozygosity Promotes Kras(G12D) -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer [作者：Skoulidis, F; Cassidy, LD; Pisupati, V; Jonasson, JG; Bjarnason, H; Eyfjord, JE; Karreth, FA; Lim, M; Barber, LM; Clatworthy, SA; Davies, SE; Olive, KP; Tuveson, DA; Venkitaraman, AR,期刊：Cancer Cell, 页码：499-509 , 文章类型： Article，,卷期：2010年18-5] Inherited heterozygous BRCA2 mutations predispose carriers to tissue-specific cancers, but somatic deletion of the wild-type allele is considered essential for carcinogenesis. We find in a murine model of familial pancre... Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized [作者：Quintana, E; Shackleton, M; Foster, HR; Fullen, DR; Sabel, MS; Johnson, TM; Morrison, SJ,期刊：Cancer Cell, 页码：510-523 , 文章类型： Article，,卷期：2010年18-5] We investigated whether melanoma is hierarchically organized into phenotypically distinct subpopulations of tumorigenic and nontumorigenic cells or whether most melanoma cells retain tumorigenic capacity, irrespective of... Distinct Clinical Phenotypes Associated with JAK2V617F Reflect Differential STAT1 Signaling [作者：Chen, E; Beer, PA; Godfrey, AL; Ortmann, CA; Li, JA; Costa-Pereira, AP; Ingle, CE; Dermitzakis, ET; Campbell, PJ; Green, AR,期刊：Cancer Cell, 页码：524-535 , 文章类型： Article，,卷期：2010年18-5] The JAK2V617F mutation is associated with distinct myeloproliferative neoplasms, including polycythemia vera (PV) and essential thrombocythemia (ET), but it remains unclear how it generates disparate disorders. By compar...