- SIK2 Is a Centrosome Kinase Required for Bipolar Mitotic Spindle Formation that Provides a Potential Target for Therapy in Ovarian Cancer
[作者：Ahmed, AA; Lu, Z; Jennings, NB; Etemadmoghadam, D; Capalbo, L; Jacamo, RO; Barbosa-Morais, N; Le, XF; Vivas-Mejia, P; Lopez-Berestein, G; Grandjean, G; Bartholomeusz, G; Liao, W; Andreeff, M; Bowtell, D; Glover, DM; Sood, AK; Bast, RC,期刊：Cancer Cell, 页码：109-121 , 文章类型： Article，,卷期：2010年18-2]
- Regulators of mitosis have been successfully targeted to enhance response to taxane chemotherapy. Here, we show that the salt inducible kinase 2 (SIK2) localizes at the centrosome, plays a key role in the initiation of m...
- Che-1 Promotes Tumor Cell Survival by Sustaining Mutant p53 Transcription and Inhibiting DNA Damage Response Activation
[作者：Bruno, T; Desantis, A; Bossi, G; Di Agostino, S; Sorino, C; De Nicola, F; Iezzi, S; Franchitto, A; Benassi, B; Galanti, S; La Rosa, F; Floridi, A; Bellacosa, A; Passananti, C; Blandino, G; Fanciulli, M,期刊：Cancer Cell, 页码：122-134 , 文章类型： Article，,卷期：2010年18-2]
- Che-1 is a RNA polymerase II binding protein involved in the regulation of gene transcription and, in response to DNA damage, promotes p53 transcription. In this study, we investigated whether Che-1 regulates mutant p53 ...
- Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis
[作者：Bennecke, M; Kriegl, L; Bajboubj, M; Retzlaff, K; Robine, S; Jung, A; Arkan, MC; Kirchner, T; Greten, FR,期刊：Cancer Cell, 页码：135-146 , 文章类型： Article，,卷期：2010年18-2]
- Colonic cancers with a serrated morphology have been proposed to comprise a molecularly distinct tumor entity following an alternative pathway of genetic alterations independently of APC mutations. We demonstrate that in...
- Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCF beta-TRCP Ubiquitin Ligase
[作者：Inuzuka, H; Tseng, A; Gao, DM; Zhai, B; Zhang, Q; Shaik, S; Wan, LX; Ang, XL; Mock, C; Yin, HQ; Stommel, JM; Gygi, S; Lahav, G; Asara, J; Xiao, ZXJ; Kaelin, WG; Harper, JW; Wei, WY,期刊：Cancer Cell, 页码：147-159 , 文章类型： Article，,卷期：2010年18-2]
- Mdm2 is the major negative regulator of the p53 pathway. Here, we report that Mdm2 is rapidly degraded after DNA damage and that phosphorylation of Mdm2 by casein kinase I (CKI) at multiple sites triggers its interaction...
- The Therapeutic Effect of Anti-HER2/neu Antibody Depends on Both Innate and Adaptive Immunity
[作者：Park, S; Jiang, ZJ; Mortenson, ED; Deng, LF; Radkevich-Brown, O; Yang, XM; Sattar, H; Wang, Y; Brown, NK; Greene, M; Liu, Y; Tang, J; Wang, SD; Fu, YX,期刊：Cancer Cell, 页码：160-170 , 文章类型： Article，,卷期：2010年18-2]
- Anti-HER2/neu antibody therapy is reported to mediate tumor regression by interrupting oncogenic signals and/or inducing FcR-mediated cytotoxicity. Here, we demonstrate that the mechanisms of tumor regression by this the...
- Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage
[作者：Koh, YJ; Kim, HZ; Hwang, SI; Lee, JE; Oh, N; Jung, K; Kim, M; Kim, KE; Kim, H; Lim, NK; Jeon, CJ; Lee, GM; Jeon, BH; Nam, DH; Sung, HK; Nagy, A; Yoo, OJ; Koh, GY,期刊：Cancer Cell, 页码：171-184 , 文章类型： Article，,卷期：2010年18-2]
- Two vascular growth factor families, VEGF and the angiopoietins, play critical and coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF and angiopoietins is not available. Here, we...
- Regulation of Tumor Angiogenesis by EZH2
[作者：Lu, CH; Han, HD; Mangala, LS; Ali-Fehmi, R; Newton, CS; Ozbun, L; Armaiz-Pena, GN; Hu, W; Stone, RL; Munkarah, A; Ravoori, MK; Shahzad, MMK; Lee, JW; Mora, E; Langley, RR; Carroll, AR; Matsuo, K; Spannuth, WA; Schmandt, R; Jennings, NB; Goodman, BW; Jaffe, RB; Nick, AM; Kim, HS; Guven, EO; Chen, YH; Li, LY; Hsu, MC; Coleman, RL; Calin, GA; Denkbas, EB; Lim, JY; Lee, JS; Kundra, V; Birrer, MJ; Hung, MC; Lopez-Berestein, G; Sood, AK,期刊：Cancer Cell, 页码：185-197 , 文章类型： Article，,卷期：2010年18-2]
- Although VEGF-targeted therapies are showing promise, new angiogenesis targets are needed to make additional gains. Here, we show that increased Zeste homolog 2 (EZH2) expression in either tumor cells or in tumor vascula...
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