- Knickkopf protein protects and organizes chitin in the newly synthesized insect exoskeleton
[作者:Chaudhari, SS; Arakane, Y; Specht, CA; Moussian, B; Boyle, DL; Park, Y; Kramer, KJ; Beeman, RW; Muthukrishnan, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17028-17033 , 文章类型: Article,,卷期:2011年108-41]
- During each molting cycle of insect development, synthesis of new cuticle occurs concurrently with the partial degradation of the overlying old exoskeleton. Protection of the newly synthesized cuticle from molting fluid ...
- More diverse plant communities have higher functioning over time due to turnover in complementary dominant species
[作者:Allan, E; Weisser, W; Weigelt, A; Roscher, C; Fischer, M; Hillebrand, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17034-17039 , 文章类型: Article,,卷期:2011年108-41]
- More diverse communities have been shown to have higher and more temporally stable ecosystem functioning than less diverse ones, suggesting they should also have a consistently higher level of functioning over time. Dive...
- Evidence for evolution in response to natural selection in a contemporary human population
[作者:Milot, E; Mayer, FM; Nussey, DH; Boisvert, M; Pelletier, F; Reale, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17040-17045 , 文章类型: Article,,卷期:2011年108-41]
- It is often claimed that modern humans have stopped evolving because cultural and technological advancements have annihilated natural selection. In contrast, recent studies show that selection can be strong in contempora...
- Interspecific Y chromosome introgressions disrupt testis-specific gene expression and male reproductive phenotypes in Drosophila
[作者:Sackton, TB; Montenegro, H; Hartl, DL; Lemos, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17046-17051 , 文章类型: Article,,卷期:2011年108-41]
- The Drosophila Y chromosome is a degenerated, heterochromatic chromosome with few functional genes. Nonetheless, natural variation on the Y chromosome in Drosophila melanogaster has substantial trans-acting effects on th...
- Quantifying why urea is a protein denaturant, whereas glycine betaine is a protein stabilizer
[作者:Guinn, EJ; Pegram, LM; Capp, MW; Pollock, MN; Record, MT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16932-16937 , 文章类型: Article,,卷期:2011年108-41]
- To explain the large, opposite effects of urea and glycine betaine (GB) on stability of folded proteins and protein complexes, we quantify and interpret preferential interactions of urea with 45 model compounds displayin...
- Inference of seed bank parameters in two wild tomato species using ecological and genetic data
[作者:Tellier, A; Laurent, SJY; Lainer, H; Pavlidis, P; Stephan, W,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17052-17057 , 文章类型: Article,,卷期:2011年108-41]
- Seed and egg dormancy is a prevalent life-history trait in plants and invertebrates whose storage effect buffers against environmental variability, modulates species extinction in fragmented habitats, and increases genet...
- Acoustic interference and recognition space within a complex assemblage of dendrobatid frogs
[作者:Amezquita, A; Flechas, SV; Lima, AP; Gasser, H; Hodl, W,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17058-17063 , 文章类型: Article,,卷期:2011年108-41]
- In species-rich assemblages of acoustically communicating animals, heterospecific sounds may constrain not only the evolution of signal traits but also the much less-studied signal-processing mechanisms that define the r...
- Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model
[作者:Meyer, C; Sevko, A; Ramacher, M; Bazhin, AV; Falk, CS; Osen, W; Borrello, I; Kato, M; Schadendorf, D; Baniyash, M; Umansky, V,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17111-17116 , 文章类型: Article,,卷期:2011年108-41]
- Tumor microenvironment is characterized by chronic inflammation represented by infiltrating leukocytes and soluble mediators, which lead to a local and systemic immunosuppression associated with cancer progression. Here,...
- Tumor suppressor protein (p)53, is a regulator of NF-kappa B repression by the glucocorticoid receptor
[作者:Murphy, SH; Suzuki, K; Downes, M; Welch, GL; De Jesus, P; Miraglia, LJ; Orth, AP; Chanda, SK; Evans, RM; Verma, IM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17117-17122 , 文章类型: Article,,卷期:2011年108-41]
- Glucocorticoids can inhibit inflammation by abrogating the activity of NF-kappa B, a family of transcription factors that regulates the production of proinflammatory cytokines. To understand the molecular mechanism of re...
- Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages
[作者:Jiang, DD; Brady, CA; Johnson, TM; Lee, EY; Park, EJ; Scott, MP; Attardi, LD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17123-17128 , 文章类型: Article,,卷期:2011年108-41]
- Over half of all human cancers, of a wide variety of types, sustain mutations in the p53 tumor suppressor gene. Although p53 limits tumorigenesis through the induction of apoptosis or cell cycle arrest, its molecular mec...
- Antiapoptotic protein Lifeguard is required for survival and maintenance of Purkinje and granular cells
[作者:de Mendoza, TH; Perez-Garcia, CG; Kroll, TT; Hoong, NH; O'Leary, DDM; Verma, IM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17189-17194 , 文章类型: Article,,卷期:2011年108-41]
- Lifeguard (LFG) is an inhibitor of Fas-mediated cell death and is highly expressed in the cerebellum. We investigated the biological role of LFG in the cerebellum in vivo, using mice with reduced LFG expression generated...
- Regulatory elements required for the activation and repression of the protocadherin-alpha gene cluster
[作者:Kehayova, P; Monahan, K; Chen, WS; Maniatis, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17195-17200 , 文章类型: Article,,卷期:2011年108-41]
- The mouse protocadherin (Pcdh) -alpha, -beta, and -gamma gene clusters encode more than 50 protein isoforms, the combinatorial expression of which generates vast single-cell diversity in the brain. At present, the mechan...
- Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)
[作者:Li, GR; Du, XL; Vass, WC; Papageorge, AG; Lowy, DR; Qian, XL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17129-17134 , 文章类型: Article,,卷期:2011年108-41]
- The deleted in liver cancer 1 (DLC1) tumor suppressor gene, which is frequently inactivated in cancer, encodes a Rho-GAP (GTPase activating protein) focal adhesion protein whose negative regulation of Rho-GTPases is nece...
- Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling
[作者:Scholer-Dahirel, A; Schlabach, MR; Loo, A; Bagdasarian, L; Meyer, R; Guo, RB; Woolfenden, S; Yu, KK; Markovits, J; Killary, K; Sonkin, D; Yao, YM; Warmuth, M; Sellers, WR; Schlegel, R; Stegmeier, F; Mosher, RE; McLaughlin, ME,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17135-17140 , 文章类型: Article,,卷期:2011年108-41]
- Persistent expression of certain oncogenes is required for tumor maintenance. This phenotype is referred to as oncogene addiction and has been clinically validated by anticancer therapies that specifically inhibit oncopr...
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