- Probing Structural Features of Alzheimer's Amyloid-beta Pores in Bilayers Using Site-Specific Amino Acid Substitutions
[作者:Capone, R; Jang, H; Kotler, SA; Kagan, BL; Nussinov, R; Lal, R,期刊:Biochemistry, 页码:776-785 , 文章类型: Article,,卷期:2012年51-3]
- A current hypothesis for the pathology of Alzheimer's disease (AD) proposes that amyloid-beta (A beta) peptides induce uncontrolled, neurotoxic ion flux across cellular membranes. The mechanism of ion flux is not fully u...
- Investigation of the Catalytic Mechanism of the Hotdog-Fold Enzyme Superfamily Pseudomonas sp Strain CBS3 4-Hydroxybenzoyl-CoA Thioesterase
[作者:Zhuang, ZH; Latham, J; Song, F; Zhang, WH; Trujillo, M; Dunaway-Mariano, D,期刊:Biochemistry, 页码:786-794 , 文章类型: Article,,卷期:2012年51-3]
- The 4-hydroxybenzoyl-CoA (4-HB-CoA) thioesterase from Pseudomonas sp. strain CBS3 catalyzes the final step of the 4-chlorobenzoate degradation pathway, which is the hydrolysis of 4-HB-CoA to coenzyme A (CoA) and 4-hydrox...
- In Vitro Stoichiometry of Complexes between the Soluble RANK Ligand and the Monoclonal Antibody Denosumab
[作者:Arthur, KK; Gabrielson, JP; Hawkins, N; Anafi, D; Wypych, J; Nagi, A; Sullivan, JK; Bondarenko, PV,期刊:Biochemistry, 页码:795-806 , 文章类型: Article,,卷期:2012年51-3]
- The in vitro binding stoichiometry of denosumab, an IgG2 fully human monoclonal therapeutic antibody, to RANK ligand was determined by multiple complementary size separation techniques with mass measuring detectors, incl...
- Solution NMR of a 463-Residue Phosphohexomutase: Domain 4 Mobility, Substates, and Phosphoryl Transfer Defect
[作者:Sarma, AVS; Anbanandam, A; Kelm, A; Mehra-Chaudhary, R; Wei, YR; Qin, PW; Lee, Y; Berjanskii, MV; Mick, JA; Beamer, LJ; Van Doren, SR,期刊:Biochemistry, 页码:807-819 , 文章类型: Article,,卷期:2012年51-3]
- Phosphomannomutase/phosphoglucomutase contributes to the infectivity of Pseudomonas aeruginosa, retains and reorients its intermediate by 180 degrees, and rotates domain 4 to close the deep catalytic cleft. Nuclear magne...
- Solution Structure of CCL21 and Identification of a Putative CCR7 Binding Site
[作者:Love, M; Sandberg, JL; Ziarek, JJ; Gerarden, KP; Rode, RR; Jensen, DR; McCaslin, DR; Peterson, FC; Veldkamp, CT,期刊:Biochemistry, 页码:733-735 , 文章类型: Article,,卷期:2012年51-3]
- CCL21 is a human chemokine that recruits normal immune cells and metastasizing tumor cells to lymph nodes through activation of the G protein-coupled receptor CCR7. The CCL21 structure solved by NMR contains a conserved ...
- Active Site Substitution A82W Improves the Regioselectivity of Steroid Hydroxylation by Cytochrome P450 BM3 Mutants As Rationalized by Spin Relaxation Nuclear Magnetic Resonance Studies
[作者:Rea, V; Kolkman, AJ; Vottero, E; Stronks, EJ; Ampt, KAM; Honing, M; Vermeulen, NPE; Wijmenga, SS; Commandeur, JNM,期刊:Biochemistry, 页码:750-760 , 文章类型: Article,,卷期:2012年51-3]
- Cytochrome P450 BM3 from Bacillus megaterium is a monooxygenase with great potential for biotechnological applications. In this paper, we present engineered drug-metabolizing P450 BM3 mutants as a novel tool for regiosel...
- Channel-Opening Kinetic Mechanism of Wild-Type GluK1 Kainate Receptors and a C-Terminal Mutant
[作者:Han, Y; Wang, CZ; Park, JS; Niu, L,期刊:Biochemistry, 页码:761-768 , 文章类型: Article,,卷期:2012年51-3]
- GluK1 is a kainate receptor subunit in the ionotropic glutamate receptor family and can form functional channels when expressed, for instance, in HEK-293 cells. However, the channel-opening mechanism of GluK1 is poorly u...
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