- Biochemical and Structural Investigations on Kynurenine Aminotransferase II: An Example of Conformation-Driven Species-Specific Inhibition?
[作者:Casazza, V; Rossi, F; Rizzi, M,期刊:Current Topics in Medicinal Chemistry, 页码:148-157 , 文章类型: Review,,卷期:2011年11-2]
- Kynurenic acid (KYNA), one of the metabolites belonging to the kynurenine pathway, has been described as an important neuroprotective compound, its unbalancing being associated with several pathological conditions. In hu...
- Melatonin-mitochondria Interplay in Health and Disease
[作者:Castroviejo, DA; Lopez, LC; Escames, G; Lopez, A; Garcia, JA; Reiter, RJ,期刊:Current Topics in Medicinal Chemistry, 页码:221-240 , 文章类型: Review,,卷期:2011年11-2]
- Although two main hypotheses of mitochondrial origin have been proposed, i.e., the autogenous and the endosymbiotic, only the second is being seriously considered currently. The 'hydrogen hypothesis' invokes metabolic sy...
- Thermal Motions of the E. coli Glucose-Galactose Binding Protein Studied Using Well-Sampled Semi-Atomistic Simulations
[作者:Cashman, DJ; Mamonov, AB; Bhatt, D; Zuckerman, DM,期刊:Current Topics in Medicinal Chemistry, 页码:211-220 , 文章类型: Review,,卷期:2011年11-2]
- The E. coli glucose-galactose chemosensory receptor is a 309 residue, 32 kDa protein consisting of two distinct structural domains. We used two computational methods to examine the protein's thermal fluctuations, includi...
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