- Predicting protein function from structure - The roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis
[作者：King, JD; Harmer, NJ; Preston, A; Palmer, CM; Rejzek, M; Field, RA; Blundell, TL; Maskell, DJ,期刊：Journal of Molecular Biology, 页码：749-763 , 文章类型： Article，,卷期：2007年374-3]
- The pathogenic bacteria Bordetella parapertussis and Bordetella bronchiseptica express a lipopolysaccharide 0 antigen containing a polymer of 2,3-diacetamido-2,3-dideoxy-L-galacturonic acid. The O-antigen cluster contain...
- cHS4 insulator-mediated alleviation of promoter interference during cell-based expression of tandemly associated transgenes
[作者：Yahata, K; Maeshima, K; Sone, T; Ando, T; Okabe, M; Imamoto, N; Imamoto, F,期刊：Journal of Molecular Biology, 页码：580-590 , 文章类型： Article，,卷期：2007年374-3]
- Expression of multiple transgenes in cells or whole organisms is a powerful tool for basic research of various biological functions and potentially for clinical applications such as gene therapy. As a model system for th...
- Crystal structure of the transcriptional regulator AcrR from Escherichia coli
[作者：Li, M; Gu, RY; Su, CC; Routh, MD; Harris, KC; Jewell, ES; McDermott, G; Yu, EW,期刊：Journal of Molecular Biology, 页码：591-603 , 文章类型： Article，,卷期：2007年374-3]
- The AcrAB multidrug efflux pump, which belongs to the resistance nodulation division (RND) family, recognizes and extrudes a wide range of antibiotics and chemotherapeutic agents and causes the intrinsic antibiotic resis...
- Phenylalanine promotes interaction of transmembrane domains via GxxxG motifs
[作者：Unterreitmeier, S; Fuchs, A; Schaffler, T; Heym, RG; Frishman, D; Langosch, D,期刊：Journal of Molecular Biology, 页码：705-718 , 文章类型： Article，,卷期：2007年374-3]
- Interactions of transmembrane helices play a crucial role in the folding and oligomerisation of integral membrane proteins. In order to uncover novel sequence motifs mediating these interactions, we randomised one face o...
- Structure of the Janus protein human CLIC2
[作者：Cromer, BA; Gorman, MA; Hansen, G; Adams, JJ; Coggan, M; Littler, DR; Brown, LJ; Mazzanti, M; Breit, SN; Curmi, PMG; Dulhunty, AF; Board, PG; Parker, MW,期刊：Journal of Molecular Biology, 页码：719-731 , 文章类型： Article，,卷期：2007年374-3]
- Chloride intracellular channel (CLIC) proteins possess the remarkable property of being able to convert from a water-soluble state to a membrane channel state. We determined the three-dimensional structure of human CLIC2...
- Structural and thermodynamic insights into the assembly of the heteromeric pyridoxal phosphate synthase from Plasmodium falciparum
[作者：Flicker, K; Neuwirth, M; Strohmeier, M; Kappes, B; Tews, I; Macheroux, P,期刊：Journal of Molecular Biology, 页码：732-748 , 文章类型： Article，,卷期：2007年374-3]
- Pyridoxal 5'-phosphate (PLP) is required as a cofactor by many enzymes. The predominant de novo biosynthetic route is catalyzed by a heteromeric glutamine amidotransferase consisting of the synthase subunit Pdx1 and the ...
- Subunit conformations and assembly states of a DNA-translocating motor: The terminase of bacteriophage P22
[作者：Nemecek, D; Gilcrease, EB; Kang, S; Prevelige, PE; Casjens, S; Thomas, GJ,期刊：Journal of Molecular Biology, 页码：817-836 , 文章类型： Article，,卷期：2007年374-3]
- Bacteriophage P22, a podovirus infecting strains of Salmonella typhimurium, packages a 42-kbp genome using a headful mechanism. DNA translocation is accomplished by the phage terminase, a powerful molecular motor consist...
- Flanking polyproline sequences inhibit beta-sheet structure in polyglutamine segments by inducing PPII-like helix structure
[作者：Darnell, G; Orgel, JPRO; Pahl, R; Meredith, SC,期刊：Journal of Molecular Biology, 页码：688-704 , 文章类型： Review，,卷期：2007年374-3]
- Polyglutamine (poly(Q)) expansion is associated with protein aggregation into beta-sheet amyloid fibrils and neuronal cytotoxicity. In the mutant poly(Q) protein huntingtin, associated with Huntington's disease, both agg...
- Exploring the mitochondrial proteome of the ciliate protozoon Tetrahymena thermophila: Direct analysis by tandem mass spectrometry
[作者：Smith, DGS; Gawryluk, RMR; Spencer, DF; Pearlman, RE; Siu, KWM; Gray, MW,期刊：Journal of Molecular Biology, 页码：837-863 , 文章类型： Review，,卷期：2007年374-3]
- To date, direct analysis of mitochondrial proteomes has largely been limited to animals, fungi and plants. To broaden our knowledge of mitochondrial structure and function, and to provide additional insight into the evol...
- Molecular basis of the Tfs1/Ira2 interaction: A combined protein engineering and molecular modelling study
[作者：Gombault, A; Godin, F; Sy, D; Legrand, B; Chautard, H; Vallee, B; Vovelle, F; Benedetti, H,期刊：Journal of Molecular Biology, 页码：604-617 , 文章类型： Article，,卷期：2007年374-3]
- Tfs1p and Ylr179cp are yeast proteins belonging to the PEBP family. Tfs1p, but not Ylr179cp, has been shown to interact with and inhibit Ira2p, a GTPase-activating protein of Ras. Tfs1p has been shown to be a specific in...
- Glutamate versus glutamine exchange swaps substrate selectivity in tRNA-guanine transglycosylase: Insight into the regulation of substrate selectivity by kinetic and crystallographic studies
[作者：Tidten, N; Stengl, B; Heine, A; Garcia, GA; Klebe, G; Reuter, K,期刊：Journal of Molecular Biology, 页码：764-776 , 文章类型： Article，,卷期：2007年374-3]
- Bacterial tRNA-guanine transglycosylase (Tgt) catalyses the exchange of guanine in the wobble position of particular tRNAs by the modified base preQ(1). In vitro, however, the enzyme is also able to insert the immediate ...
- Differential ubiquitination of Smad1 mediated by CHIP: Implications in the regulation of the bone morphogenetic protein signaling pathway
[作者：Li, RF; Shang, Y; Liu, D; Ren, ZS; Chang, Z; Sui, SF,期刊：Journal of Molecular Biology, 页码：777-790 , 文章类型： Article，,卷期：2007年374-3]
- Smad1, a downstream regulator of the bone morphogenetic protein (BMP) receptors, is tightly regulated by the ubiquitin-proteasomal degradation system. To dissect the mechanisms that underlie the regulation of Smad1, it i...
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