- Sequence determinants for amyloid fibrillogenesis of human alpha-synuclein
[作者:Zibaee, S; Jakes, R; Fraser, G; Serpell, LC; Crowther, RA; Goedert, M,期刊:Journal of Molecular Biology, 页码:454-464 , 文章类型: Article,,卷期:2007年374-2]
- Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are characterized by the presence of filamentous inclusions in nerve cells. These filaments are amyloid fibrils that are made of the protein a-synuclein, which...
- R-subunit isoform specificity in protein kinase A: Distinct features of protein interfaces in PKA types I and II by amide H/H-2 exchange mass spectrometry
[作者:Anand, GS; Hotchko, M; Brown, SHJ; Ten Eyck, LF; Komives, EA; Taylor, SS,期刊:Journal of Molecular Biology, 页码:487-499 , 文章类型: Article,,卷期:2007年374-2]
- The two isoforms (RI and RII) of the regulatory (R) subunit of cAMP-dependent protein kinase or protein kinase A (PKA) are similar in sequence yet have different biochemical properties and physiological functions. To fur...
- Structural analysis of kinetic folding intermediates for a TIM barrel protein, indole-3-glycerol phosphate synthase, by hydrogen exchange mass spectrometry and G(o)over-bar model simulation
[作者:Gu, Z; Rao, MK; Forsyth, WR; Finke, JM; Matthews, CR,期刊:Journal of Molecular Biology, 页码:528-546 , 文章类型: Article,,卷期:2007年374-2]
- The structures of partially folded states appearing during the folding of a (beta alpha)(8) TIM barrel protein, the indole-3-glycerol phosphate synthase from Sulfolobus solfataricus (sIGPS), was assessed by hydrogen exch...
- Dynamics of a benzo[a]pyrene-derived guanine DNA lesion in TGT and CGC sequence contexts: Enhanced mobility in TGT explains conformational heterogeneity, flexible bending, and greater susceptibility to nucleotide excision repair
[作者:Cai, Y; Patel, DJ; Geacintov, NE; Broyde, S,期刊:Journal of Molecular Biology, 页码:292-305 , 文章类型: Article,,卷期:2007年374-2]
- The nucleotide excision repair (NER) machinery excises a variety of bulky DNA lesions, but with varying efficiencies. The structural features of the DNA lesions that govern these differences are not well understood. An i...
- Bis-methionyl coordination in the crystal structure of the heme-binding domain of the streptococcal cell surface protein shp
[作者:Aranda, R; Worley, CE; Liu, M; Bitto, E; Cates, MS; Olson, JS; Lei, B; Phillips, GN,期刊:Journal of Molecular Biology, 页码:374-383 , 文章类型: Article,,卷期:2007年374-2]
- Surface proteins Shr, Shp, and the ATP-binding cassette (ABC) transporter HtsABC are believed to make up the machinery for heme uptake in Streptococcus pyogenes. Shp transfers its heme to HtsA, the lipoprotein component ...
- Crystal structure of glycoside hydrolase family 78 alpha-L-rhamnosidase from Bacillus sp GL1
[作者:Cui, Z; Maruyama, Y; Mikami, B; Hashimoto, W; Murata, K,期刊:Journal of Molecular Biology, 页码:384-398 , 文章类型: Article,,卷期:2007年374-2]
- alpha-L-Rhamnosidase (EC 3.2.1.40) catalyzes the hydrolytic release of rhamnose from polysaccharides and glycosides. Bacillus sp. GL1 alpha-L-rhamnosidase (RhaB), a member of glycoside hydrolase (GH) family 78, is respon...
- Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments
[作者:Coquelle, N; Fioravanti, E; Weik, M; Vellieux, F; Madern, D,期刊:Journal of Molecular Biology, 页码:547-562 , 文章类型: Article,,卷期:2007年374-2]
- Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate with concomitant oxidation of NADH during the last step in anaerobic glycolysis. In the present study, we present a comparative biochemical and ...
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