- Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans
[作者:Anzai, N; Ichida, K; Jutabha, P; Kimura, T; Babu, E; Jin, CJ; Srivastava, S; Kitamura, K; Hisatome, I; Endou, H; Sakurai, H,期刊:Journal of Biological Chemistry, 页码:26834-26838 , 文章类型: Article,,卷期:2008年283-40]
- Hyperuricemia is a significant factor in a variety of diseases, including gout and cardiovascular diseases. Although renal excretion largely determines plasma urate concentration, the molecular mechanism of renal urate h...
- Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner
[作者:Ding, Q; Gladson, CL; Wu, HJ; Hayasaka, H; Olman, MA,期刊:Journal of Biological Chemistry, 页码:26839-26849 , 文章类型: Article,,卷期:2008年283-40]
- Transforming growth factor (TGF)-beta 1 induces fibroblast transdifferentiation to myofibroblasts, a process that requires the involvement of integrin-mediated signaling and focal adhesion kinase (FAK). FAK-related non-k...
- Suppression of lipopolysaccharide-stimulated tumor necrosis factor-alpha production by adiponectin is mediated by transcriptional and post-transcriptional mechanisms
[作者:Park, PH; Huang, HL; McMullen, MR; Mandal, P; Sun, L; Nagy, LE,期刊:Journal of Biological Chemistry, 页码:26850-26858 , 文章类型: Article,,卷期:2008年283-40]
- Adiponectin is an adipokine with potent anti-inflammatory properties. Treatment of macrophages with adiponectin results in a suppression of lipopolysaccharide (LPS)-stimulated cytokine production. Here we investigated th...
- Activity determinants and functional specialization of Arabidopsis PEN1 syntaxin in innate immunity
[作者:Pajonk, S; Kwon, C; Clemens, N; Panstruga, R; Schulze-Lefert, P,期刊:Journal of Biological Chemistry, 页码:26974-26984 , 文章类型: Article,,卷期:2008年283-40]
- In eukaryotes, proteins of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family are believed to have a general role for the fusion of intracellular transport vesicles with acceptor mem...
- Phosphorylation of MUC1 by met modulates interaction with p53 and MMP1 expression
[作者:Singh, PK; Behrens, ME; Eggers, JP; Cerny, RL; Bailey, JM; Shanmugam, K; Gendler, SJ; Bennett, EP; Hollingsworth, MA,期刊:Journal of Biological Chemistry, 页码:26985-26995 , 文章类型: Article,,卷期:2008年283-40]
- MUC1, a transmembrane mucin, is a key modulator of several signaling pathways that affect oncogenesis, motility, and cell morphology. The interaction of MUC1 cytoplasmic tail (MUC1CT) with signal transducers and its nucl...
- cAMP-responding element-binding protein and c-Ets1 interact in the regulation of ATP-dependent MUC5AC gene expression
[作者:Song, KS; Lee, TJ; Kim, K; Chung, KC; Yoon, JH,期刊:Journal of Biological Chemistry, 页码:26869-26878 , 文章类型: Article,,卷期:2008年283-40]
- Exogenous ATP activates purinoreceptors on the cell surface that regulate diverse cellular functions, including mucous cell secretion in the respiratory epithelium. In this study, ATP increased MUC5AC mRNA in primary hum...
- Coordinate activation of human platelet protease-activated receptor-1 and-4 in response to subnanomolar alpha-thrombin
[作者:Ofosu, FA; Dewar, L; Craven, SJ; Song, YQ; Cedrone, A; Freedman, J; Fenton, JW,期刊:Journal of Biological Chemistry, 页码:26886-26893 , 文章类型: Article,,卷期:2008年283-40]
- We previously demonstrated that human platelets activated with SFLLRN release PAR-1 activation peptide, PAR-1-(1-41), even in the presence of hirudin. This observation suggests that during their activation, platelets gen...
- Histone 2B (H2B) expression is confined to a proper NAD(+)/NADH redox status
[作者:Dai, RP; Yu, FX; Goh, SR; Chng, HW; Tan, YL; Fu, JL; Zheng, L; Luo, Y,期刊:Journal of Biological Chemistry, 页码:26894-26901 , 文章类型: Article,,卷期:2008年283-40]
- S-phase transcription of the histone 2B (H2B) gene is dependent on Octamer-binding factor 1 (Oct-1) and Oct-1 Co-Activator in S-phase (OCA-S), a protein complex comprising glyceraldehyde-3-phosphate dehydrogenase and lac...
- Dictyostelium myosin-5b is a conditional processive motor
[作者:Taft, MH; Hartmann, FK; Rump, A; Keller, H; Chizhov, I; Manstein, DJ; Tsiavaliaris, G,期刊:Journal of Biological Chemistry, 页码:26902-26910 , 文章类型: Article,,卷期:2008年283-40]
- Dictyostelium myosin-5b is the gene product of myoJ and one of two closely related myosin-5 isoenzymes produced in Dictyostelium discoideum. Here we report a detailed investigation of the kinetic and functional propertie...
- Histamine induces Egr-1 expression in human aortic endothelial cells via the H1 receptor-mediated protein kinase C delta-dependent ERK activation pathway
[作者:Hao, F; Tan, MQ; Xu, XM; Cui, MZ,期刊:Journal of Biological Chemistry, 页码:26928-26936 , 文章类型: Article,,卷期:2008年283-40]
- Histamine, a potent inflammatory mediator, has multiple effects on the pathogenesis of atherosclerosis. This study investigates the effect of histamine on the expression of early growth response factor 1 (Egr-1), a maste...
- A network of Kruppel-like factors (klfs) - Klf8 is repressed by Klf3 and activated by Klf1 in vivo
[作者:Eaton, SA; Funnell, APW; Sue, N; Nicholas, H; Pearson, RCM; Crossley, M,期刊:Journal of Biological Chemistry, 页码:26937-26947 , 文章类型: Article,,卷期:2008年283-40]
- Transcription factors of the Sp/Klf (Kruppel-like factor) family regulate biological processes such as hematopoiesis, adipogenesis, and stem cell maintenance. Here we show that Bklf or Klf3 ( Basic Kruppel-like factor) r...
- Mitochondrial oxidative phosphorylation is regulated by fructose 1,6-bisphosphate - A possible role in Crabtree effect induction?
[作者:Diaz-Ruiz, R; Averet, N; Araiza, D; Pinson, B; Uribe-Carvajal, S; Devin, A; Rigoulet, M,期刊:Journal of Biological Chemistry, 页码:26948-26955 , 文章类型: Article,,卷期:2008年283-40]
- In numerous cell types, tumoral cells, proliferating cells, bacteria, and yeast, respiration is inhibited when high concentrations of glucose are added to the culture medium. This phenomenon has been named the "Crabtree ...
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