- Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)
[作者:Finn, RD; McLaughlin, LA; Ronseaux, S; Rosewell, I; Houston, JB; Henderson, CJ; Wolf, CR,期刊:Journal of Biological Chemistry, 页码:31385-31393 , 文章类型: Article,,卷期:2008年283-46]
- In vitro, cytochrome b(5) modulates the rate of cytochrome P450-dependent mono-oxygenation reactions. However, the role of this enzyme in determining drug pharmacokinetics in vivo and the consequential effects on drug ab...
- Requirement of Inducible Nitric-oxide Synthase in Lipopolysaccharide-mediated Src Induction and Macrophage Migration
[作者:Maa, MC; Chang, MY; Chen, YJ; Lin, CH; Yu, CJ; Yang, YL; Li, JR; Chen, PR; Tang, CH; Lei, HY; Leu, TH,期刊:Journal of Biological Chemistry, 页码:31408-31416 , 文章类型: Article,,卷期:2008年283-46]
- Previously, we have demonstrated the induction of Src in lipopolysaccharide (LPS)-stimulated macrophages. In this study, we observed that pharmacological blockade or knockout of inducible nitric-oxide synthase (iNOS) red...
- Identification of Mycobacterium tuberculosis Clinical Isolates with Altered Phagocytosis by Human Macrophages Due to a Truncated Lipoarabinomannan
[作者:Torrelles, JB; Knaup, R; Kolareth, A; Slepushkina, T; Kaufman, TM; Kang, P; Hill, PJ; Brennan, PJ; Chatterjee, D; Belisle, JT; Musser, JM; Schlesinger, LS,期刊:Journal of Biological Chemistry, 页码:31417-31428 , 文章类型: Article,,卷期:2008年283-46]
- Phenotypically distinct clinical isolates of Mycobacterium tuberculosis are capable of altering the balance that exists between the pathogen and human host and ultimately the outcome of infection. This study has identifi...
- Characterization of Ser(338) Phosphorylation for Raf-1 Activation
[作者:Zang, MW; Gong, J; Luo, LQ; Zhou, J; Xiang, XQ; Huang, W; Huang, QR; Luo, XX; Olbrot, M; Peng, YH; Chen, CY; Luo, ZJ,期刊:Journal of Biological Chemistry, 页码:31429-31437 , 文章类型: Article,,卷期:2008年283-46]
- Raf kinases are essential for regulating cell proliferation, survival, and tumorigenesis. However, the mechanisms by which Raf is activated are still incompletely understood. Phosphorylation plays a critical role in Raf ...
- Tunable Calcium Current through TRPV1 Receptor Channels
[作者:Samways, DSK; Khakh, BS; Egan, TM,期刊:Journal of Biological Chemistry, 页码:31274-31278 , 文章类型: Article,,卷期:2008年283-46]
- TRPV1 receptors are polymodal cation channels that open in response to diverse stimuli including noxious heat, capsaicin, and protons. Because Ca2+ is vital for TRPV1 signaling, we sought to precisely measure its contrib...
- The Structural Basis for T-antigen Hydrolysis by Streptococcus pneumoniae A TARGET FOR STRUCTURE-BASED VACCINE DESIGN
[作者:Caines, MEC; Zhu, HZ; Vuckovic, M; Willis, LM; Withers, SG; Wakarchuk, WW; Strynadka, NCJ,期刊:Journal of Biological Chemistry, 页码:31279-31283 , 文章类型: Article,,卷期:2008年283-46]
- Streptococcus pneumoniae endo-alpha-N-acetylgalactosaminidase is a cell surface-anchored glycoside hydrolase from family GH101 involved in the breakdown of mucin type O-linked glycans. The 189-kDa mature enzyme specifica...
- The Antiherpetic Drug Acyclovir Inhibits HIV Replication and Selects the V75I Reverse Transcriptase Multidrug Resistance Mutation
[作者:McMahon, MA; Siliciano, JD; Lai, J; Liu, JO; Stivers, JT; Siliciano, RF; Kohli, RM,期刊:Journal of Biological Chemistry, 页码:31289-31293 , 文章类型: Article,,卷期:2008年283-46]
- The antiviral drug acyclovir is a guanosine nucleoside analog that potently inhibits herpes simplex virus (HSV) replication. Acyclovir treatment in patients coinfected with HSV and human immunodeficiency virus (HIV) has ...
- Kinetic Analyses of the Magnesium Chelatase Provide Insights into the Mechanism, Structure, and Formation of the Complex
[作者:Sawicki, A; Willows, RD,期刊:Journal of Biological Chemistry, 页码:31294-31302 , 文章类型: Article,,卷期:2008年283-46]
- The metabolic pathway known as (bacterio) chlorophyll biosynthesis is initiated by magnesium chelatase (BchI, BchD, BchH). This first step involves insertion of magnesium into protoporphyrin IX (proto), a process requiri...
- Impaired Cardiac Contractility in Mice Lacking Both the AE3 Cl-/HCO3- Exchanger and the NKCC1 Na+-K+-2Cl(-) Cotransporter EFFECTS ON Ca2+ HANDLING AND PROTEIN PHOSPHATASES
[作者:Prasad, V; Bodi, I; Meyer, JW; Wang, YG; Ashraf, M; Engle, SJ; Doetschman, T; Sisco, K; Nieman, ML; Miller, ML; Lorenz, JN; Shull, GE,期刊:Journal of Biological Chemistry, 页码:31303-31314 , 文章类型: Article,,卷期:2008年283-46]
- To analyze the cardiac functions of AE3, we disrupted its gene (Slc4a3) in mice. Cl-/HCO3- exchange coupled with Na+-dependent acid extrusion can mediate pH-neutral Na+ uptake, potentially affecting Ca2+ handling via eff...
- Biophysical Characterization of the Interaction between Hepatic Glucokinase and Its Regulatory Protein IMPACT OF PHYSIOLOGICAL AND PHARMACOLOGICAL EFFECTORS
[作者:Anderka, O; Boyken, J; Aschenbach, U; Batzer, A; Boscheinen, O; Schmoll, D,期刊:Journal of Biological Chemistry, 页码:31333-31340 , 文章类型: Article,,卷期:2008年283-46]
- Glucokinase (GK) is a key enzyme of glucose metabolism in liver and pancreatic beta-cells, and small molecule activators of GK (GKAs) are under evaluation for the treatment of type 2 diabetes. In liver, GK activity is co...
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