- Structure and Hemimethylated CpG Binding of the SRA Domain from Human UHRF1
[作者:Qian, CM; Li, SD; Jakoncic, J; Zeng, L; Walsh, MJ; Zhou, MM,期刊:Journal of Biological Chemistry, 页码:34490-34494 , 文章类型: Article,,卷期:2008年283-50]
- Human UHRF1((u) under bar biquitin-like P (H) under barD and (R) under bar ING (f) under bar inger (1) under bar) functions to maintain CpG DNA methylation patterns through DNA replication by co-localizing with the DNA m...
- Differential Dependence of Hypoxia-inducible Factors 1 alpha and 2 alpha on mTORC1 and mTORC2
[作者:Toschi, A; Lee, E; Gadir, N; Ohh, M; Foster, DA,期刊:Journal of Biological Chemistry, 页码:34495-34499 , 文章类型: Article,,卷期:2008年283-50]
- Constitutive expression of hypoxia-inducible factor (HIF) has been implicated in several proliferative disorders. Constitutive expression of HIF1 alpha and HIF2 alpha has been linked to a number of human cancers, especia...
- Abnormal Patterns of Lipoprotein Lipase Release into the Plasma in GPIHBP1-deficient Mice
[作者:Weinstein, MM; Yin, L; Beigneux, AP; Davies, BSJ; Gin, P; Estrada, K; Melford, K; Bishop, JR; Esko, JD; Dallinga-Thie, GM; Fong, LG; Bensadoun, A; Young, SG,期刊:Journal of Biological Chemistry, 页码:34511-34518 , 文章类型: Article,,卷期:2008年283-50]
- GPIHBP1-deficient mice (Gpihbp1(-/-)) exhibit severe chylomicronemia. GPIHBP1 is located within capillaries of muscle and adipose tissue, and expression of GPIHBP1 in Chinese hamster ovary cells confers upon those cells ...
- Locally Generated Methylseleninic Acid Induces Specific Inactivation of Protein Kinase C Isoenzymes RELEVANCE TO SELENIUM-INDUCED APOPTOSIS IN PROSTATE CANCER CELLS
[作者:Gundimeda, U; Schiffman, JE; Chhabra, D; Wong, J; Wu, A; Gopalakrishna, R,期刊:Journal of Biological Chemistry, 页码:34519-34531 , 文章类型: Article,,卷期:2008年283-50]
- In this study, we show that methylselenol, a selenometabolite implicated in cancer prevention, did not directly inactivate protein kinase C (PKC). Nonetheless, its oxidation product, methylseleninic acid (MSA), inactivat...
- The Low Density Lipoprotein Receptor-related Protein 1 Mediates Uptake of Amyloid beta Peptides in an in Vitro Model of the Blood-Brain Barrier Cells
[作者:Yamada, K; Hashimoto, T; Yabuki, C; Nagae, Y; Tachikawa, M; Strickland, DK; Liu, Q; Bu, G; Basak, JM; Holtzman, DM; Ohtsuki, S; Terasaki, T; Iwatsubo, T,期刊:Journal of Biological Chemistry, 页码:34554-34562 , 文章类型: Article,,卷期:2008年283-50]
- The metabolism of amyloid beta peptide (A beta) in the brain is crucial to the pathogenesis of Alzheimer disease. A body of evidence suggests that A beta is actively transported from brain parenchyma to blood across the ...
- Kinetic Characterization of Lipid II-Ala:Alanyl-tRNA Ligase (MurN) from Streptococcus pneumoniae using Semisynthetic Aminoacyl-lipid II Substrates
[作者:De Pascale, G; Lloyd, AJ; Schouten, JA; Gilbey, AM; Roper, DI; Dowson, CG; Bugg, TDH,期刊:Journal of Biological Chemistry, 页码:34571-34579 , 文章类型: Article,,卷期:2008年283-50]
- MurM and MurN are tRNA-dependent ligases that catalyze the addition of the first (L-Ala/L-Ser) and second (L-Ala) amino acid onto lipid II substrates in the biosynthesis of the peptidoglycan layer of Streptococcus pneumo...
- Active Cystathionine beta-Synthase Can Be Expressed in Heme-free Systems in the Presence of Metal-substituted Porphyrins or a Chemical Chaperone
[作者:Majtan, T; Singh, LR; Wang, LQ; Kruger, WD; Kraus, JP,期刊:Journal of Biological Chemistry, 页码:34588-34595 , 文章类型: Article,,卷期:2008年283-50]
- Cystathionine beta-synthase (CBS), a key enzyme in the metabolism of homocysteine, has previously been shown to require a heme co-factor for maximal activity. However, the biochemical function of the CBS heme is not well...
- Extreme Substrate Promiscuity of the Neisseria Oligosaccharyl Transferase Involved in Protein O-Glycosylation
[作者:Faridmoayer, A; Fentabil, MA; Haurat, MF; Yi, W; Woodward, R; Wang, PG; Feldman, MF,期刊:Journal of Biological Chemistry, 页码:34596-34604 , 文章类型: Article,,卷期:2008年283-50]
- Neisseria meningitidis PglL belongs to a novel family of bacterial oligosaccharyltransferases (OTases) responsible for O-glycosylation of type IV pilins. Although members of this family are widespread among pathogenic ba...
- Mechanism of Radical-based Catalysis in the Reaction Catalyzed by Adenosylcobalamin-dependent Ornithine 4,5-Aminomutase
[作者:Wolthers, KR; Rigby, SEJ; Scrutton, NS,期刊:Journal of Biological Chemistry, 页码:34615-34625 , 文章类型: Article,,卷期:2008年283-50]
- We report an analysis of the reaction mechanism of ornithine 4,5-aminomutase, an adenosylcobalamin (AdoCbl)- and pyridoxal L-phosphate (PLP)-dependent enzyme that catalyzes the 1,2-rearrangement of the terminal amino gro...
- G4 Resolvase 1 Binds Both DNA and RNA Tetramolecular Quadruplex with High Affinity and Is the Major Source of Tetramolecular Quadruplex G4-DNA and G4-RNA Resolving Activity in HeLa Cell Lysates
[作者:Creacy, SD; Routh, ED; Iwamoto, F; Nagamine, Y; Akman, SA; Vaughn, JP,期刊:Journal of Biological Chemistry, 页码:34626-34634 , 文章类型: Article,,卷期:2008年283-50]
- Quadruplex structures that result from stacking of guanine quartets in nucleic acids possess such thermodynamic stability that their resolution in vivo is likely to require specific recognition by specialized enzymes. We...
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