个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Teaching the design principles of metabolism [作者：RABINOWITZ JOSHUA D; VASTAG LIVIA,期刊：NATURE CHEMICAL BIOLOGY, 页码：497-501 , 文章类型： Editorial Material，,卷期：2012年8-6] STRUCTURAL BIOLOGY CrkL is not Crk-like [作者：KOBASHIGAWA YOSHIHIRO; INAGAKI FUYUHIKO,期刊：NATURE CHEMICAL BIOLOGY, 页码：504-505 , 文章类型： News Item，,卷期：2012年8-6] BIOSYNTHESIS Ringing in a new view [作者：KELLY WENDY L,期刊：NATURE CHEMICAL BIOLOGY, 页码：505-507 , 文章类型： News Item，,卷期：2012年8-6] ANTISENSE THERAPEUTICS New ways to nudge splicing [作者：EPERON IAN,期刊：NATURE CHEMICAL BIOLOGY, 页码：507-508 , 文章类型： News Item，,卷期：2012年8-6] Rethinking glycolysis: on the biochemical logic of metabolic pathways [作者：BAREVEN ARREN; FLAMHOLZ AVI; NOOR ELAD; MILO RON,期刊：NATURE CHEMICAL BIOLOGY, 页码：509-517 , 文章类型： Review，,卷期：2012年8-6] Metabolic pathways may seem arbitrary and unnecessarily complex. In many cases, a chemist might devise a simpler route for the biochemical transformation, so why has nature chosen such complex solutions? In this review, ... Engineering synthetic recursive pathways to generate non-natural small molecules [作者：FELNAGLE LIZABETH A; CHAUBEY ASHA; NOEY ELIZABETH L; HOUK KENDALL N; LIAO JAMES C,期刊：NATURE CHEMICAL BIOLOGY, 页码：518-526 , 文章类型： Review，,卷期：2012年8-6] Recursive pathways are broadly defined as those that catalyze a series of reactions such that the key, bond-forming functional group of the substrate is always regenerated in each cycle, allowing for a new cycle of react... Natural strategies for the spatial optimization of metabolism in synthetic biology [作者：AGAPAKIS CHRISTINA M; BOYLE PATRICK M; SILVER PAMELA A,期刊：NATURE CHEMICAL BIOLOGY, 页码：527-535 , 文章类型： Review，,卷期：2012年8-6] Metabolism is a highly interconnected web of chemical reactions that power life. Though the stoichiometry of metabolism is well understood, the multidimensional aspects of metabolic regulation in time and space remain di... Systems metabolic engineering of microorganisms for natural and non-natural chemicals [作者：LEE JEONG WOOK; NA DOKYUN; PARK JONG MYOUNG; LEE JOUNGMIN; CHOI SOL; LEE SANG YUP,期刊：NATURE CHEMICAL BIOLOGY, 页码：536-546 , 文章类型： Review，,卷期：2012年8-6] Growing concerns over limited fossil resources and associated environmental problems are motivating the development of sustainable processes for the production of chemicals, fuels and materials from renewable resources. ... Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-gamma and p53 signaling [作者：SAJISH MATHEW; ZHOU QUANSHENG; KISHI SHUJI; VALDEZ DELGADO M JR; KAPOOR MILI; GUO MIN; LEE SUNHEE; KIM SUNGHOON; YANG XIANGLEI; SCHIMMEL PAUL,期刊：NATURE CHEMICAL BIOLOGY, 页码：547-554 , 文章类型： Article，,卷期：2012年8-6] Interferon-gamma (IFN-gamma) engenders strong antiproliferative responses, in part through activation of p53. However, the long-known IFN-gamma-dependent upregulation of human Trp-tRNA synthetase (TrpRS), a cytoplasmic e... Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing [作者：RIGO FRANK; HUA YIMIN; CHUN SEUNG J; PRAKASH THAZHA P; KRAINER ADRIAN R; BENNETT C FRANK,期刊：NATURE CHEMICAL BIOLOGY, 页码：555-561 , 文章类型： Article，,卷期：2012年8-6] We describe a new technology for recruiting specific proteins to RNA through selective recognition of heteroduplexes formed with chemically modified antisense oligonucleotides (ASOs). Typically, ASOs function by hybridiz... Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase [作者：XU YIFAN; AMADORNOGUEZ DANIEL; REAVES MARSHALL LOUIS; FENG XIAOJIANG; RABINOWITZ JOSHUA D,期刊：NATURE CHEMICAL BIOLOGY, 页码：562-568 , 文章类型： Article，,卷期：2012年8-6] Anapleurosis is the filling of the tricarboxylic acid cycle with four-carbon units. The common substrate for both anapleurosis and glucose phosphorylation in bacteria is the terminal glycolytic metabolite phosphoenolpyru... YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations [作者：DUNBAR KYLE L; MELBY JOEL O; MITCHELL DOUGLAS A,期刊：NATURE CHEMICAL BIOLOGY, 页码：569-575 , 文章类型： Article，,卷期：2012年8-6] Thiazole/oxazole-modified microcins (TOMMs) encompass a recently defined class of ribosomally synthesized natural products with a diverse set of biological activities. Although TOMM biosynthesis has been investigated for... A selective inhibitor reveals PI3K gamma dependence of T(H)17 cell differentiation [作者：BERGAMINI GIOVANNA; BELL KATHRYN; SHIMAMURA SATOKO; WERNER THILO; CANSFIELD ANDREW; MUELLER KATRIN; PERRIN JESSICA; RAU CHRISTINA; ELLARD KATIE; HOPF CARSTEN; DOCE CAROLA; LEGGATE DANIEL; MANGANO RAFFAELLA; MATHIESON TOBY; OMAHONY ALISON; PLAVEC IVAN; RHARBAOUI FAIZA; REINHARD FRIEDRICH; SAVITSKI MIKHAIL M; RAMSDEN NIGEL; HIRSCH EMILIO; DREWES GERARD; RAUSCH OLIVER; BANTSCHEFF MARCUS; NEUBAUER GITTE,期刊：NATURE CHEMICAL BIOLOGY, 页码：576-582 , 文章类型： Article，,卷期：2012年8-6] We devised a high-throughput chemoproteomics method that enabled multiplexed screening of 16,000 compounds against native protein and lipid kinases in cell extracts. Optimization of one chemical series resulted in CZC248... Fluorescent castasterone reveals BRI1 signaling from the plasma membrane [作者：IRANI NILOUFER G; DI RUBBO SIMONE; MYLLE EVELIEN; VAN DEN BEGIN JOS; SCHNEIDERPIZON JOANNA; HNILIKOVA JAROSLAVA; SISA MIROSLAV; BUYST DIETER; VILARRASABLASI JOSEP; SZATMARI ANNAMARIA; VAN DAMME DANIEL; MISHEV KIRIL; CODREANU MIRELACORINA; KOHOUT LADISLAV; STRNAD MIROSLAV; CANODELGADO ANA I; FRIML JIRI; MADDER ANNEMIEKE; RUSSINOVA EUGENIA,期刊：NATURE CHEMICAL BIOLOGY, 页码：583-589 , 文章类型： Article，,卷期：2012年8-6] Receptor-mediated endocytosis is an integral part of signal transduction as it mediates signal attenuation and provides spatial and temporal dimensions to signaling events. One of the best-studied leucine-rich repeat rec... Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII [作者：JANKOWSKI WOJCIECH; SALEH TAMJEED; PAI MINGTAO; SRIRAM GANAPATHY; BIRGE RAYMOND B; KALODIMOS CHARALAMPOS G,期刊：NATURE CHEMICAL BIOLOGY, 页码：590-596 , 文章类型： Article，,卷期：2012年8-6] CrkL is a key signaling protein that mediates the leukemogenic activity of Bcr-Abl. CrkL is thought to adopt a structure that is similar to that of its CrkII homolog. The two proteins share high sequence identity and ind... Beyond blueprints [作者：ANONYMOUS,期刊：NATURE CHEMICAL BIOLOGY, 页码：495-495 , 文章类型： Editorial Material，,卷期：2012年8-6]