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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation [作者：REXACH JESSICA E; CLARK PETER M; MASON DANIEL E; NEVE RACHAEL L; PETERS ERIC C; HSIEHWILSON LINDA C,期刊：NATURE CHEMICAL BIOLOGY, 页码：253-261 , 文章类型： Article，,卷期：2012年8-3] The transcription factor cyclic AMP-response element binding protein (CREB) is a key regulator of many neuronal processes, including brain development, circadian rhythm and long-term memory. Studies of CREB have focused ... Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis [作者：TARRANT MARY KATHERINE; RHO HEESOOL; XIE ZHI; JIANG YU LIN; GROSS CHRISTOPHER; CULHANE JEFFREY C; YAN GAI; QIAN JIANG; ICHIKAWA YOSHITAKA; MATSUOKA TATSUJI; ZACHARA NATASHA; ETZKORN FELICIA A; HART GERALD W; JEONG JUN SEOP; BLACKSHAW SETH; ZHU HENG; COLE PHILIP A,期刊：NATURE CHEMICAL BIOLOGY, 页码：262-269 , 文章类型： Article，,卷期：2012年8-3] Protein serine-threonine kinase casein kinase 3II (CK2) is involved in a myriad of cellular processes including cell growth and proliferation through its phosphorylation of hundreds of substrates, yet how CK2 function is... Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development [作者：SHESTOPALOV ILYA A; PITT CAMERON L W; CHEN JAMES K,期刊：NATURE CHEMICAL BIOLOGY, 页码：270-276 , 文章类型： Article，,卷期：2012年8-3] Transcription factors have diverse roles during embryonic development, combinatorially controlling cellular states in a spatially and temporally defined manner. Resolving the dynamic transcriptional profiles that underli... Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia [作者：GREMBECKA JOLANTA; HE SHIHAN; SHI AIBIN; PUROHIT TRUPTA; MUNTEAN ANDREW G; SORENSON RODERICK J; SHOWALTER HOLLIS D; MURAI MARCELO J; BELCHER AMALIA M; HARTLEY THOMAS; HESS JAY L; CIERPICKI TOMASZ,期刊：NATURE CHEMICAL BIOLOGY, 页码：277-284 , 文章类型： Article，,卷期：2012年8-3] Translocations involving the mixed lineage leukemia (MLL) gene result in human acute leukemias with very poor prognosis. The leukemogenic activity of MLL fusion proteins is critically dependent on their direct interactio... BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia [作者：HANTSCHEL OLIVER; WARSCH WOLFGANG; ECKELHART EVA; KAUPE INES; GREBIEN FLORIAN; WAGNER KAYUWE; SUPERTIFURGA GIULIO; SEXL VERONIKA,期刊：NATURE CHEMICAL BIOLOGY, 页码：285-293 , 文章类型： Article，,卷期：2012年8-3] Constitutive activation of STAT5 is critical for the maintenance of chronic myeloid leukemia (CML) characterized by the BCR-ABL oncoprotein. Tyrosine kinase inhibitors (TKIs) for the STAT5-activating kinase JAK2 have bee... Small-molecule-induced DNA damage identifies alternative DNA structures in human genes [作者：RODRIGUEZ RAPHAEL; MILLER KYLE M; FORMENT JOSEP V; BRADSHAW CHARLES R; NIKAN MEHRAN; BRITTON SEBASTIEN; OELSCHLAEGEL TOBIAS; XHEMALCE BLERTA; BALASUBRAMANIAN SHANKAR; JACKSON STEPHEN P,期刊：NATURE CHEMICAL BIOLOGY, 页码：301-310 , 文章类型： Article，,卷期：2012年8-3] Guanine-rich DNA sequences that can adopt non-Watson-Crick structures in vitro are prevalent in the human genome. Whether such structures normally exist in mammalian cells has, however, been the subject of active researc... Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase [作者：KELLER TRACY L; ZOCCO DAVIDE; SUNDRUD MARK S; HENDRICK MARGARET; EDENIUS MAJA; YUM JINAH; KIM YEONJIN; LEE HAKKYO; CORTESE JOSEPH F; WIRTH DYANN F; DIGNAM JOHN DAVID; RAO ANJANA; YEO CHANGYEOL; MAZITSCHEK RALPH; WHITMAN MALCOLM,期刊：NATURE CHEMICAL BIOLOGY, 页码：311-317 , 文章类型： Article，,卷期：2012年8-3] Febrifugine, the bioactive constituent of one of the SO fundamental herbs of traditional Chinese medicine, has been characterized for its therapeutic activity, though its molecular target has remained unknown. Febrifugin... Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans (vol 7, pg 891, 2011) [作者：LUCIANI GENNA M; MAGOMEDOVA LILIA; PUCKRIN RACHEL; URBANUS MALENE L; WALLACE IAIN M; GIAEVER GURI; NISLOW COREY; CUMMINS CAROLYN L; ROY PETER J,期刊：NATURE CHEMICAL BIOLOGY, 页码：318-318 , 文章类型： Correction，,卷期：2012年8-3] Identifying polyglutamine protein species in situ that best predict neurodegeneration (vol 7, pg 925, 2011) [作者：MILLER JASON; ARRASATE MONTSERRAT; BROOKS ELIZABETH; LIBEU CLARE PETERS; LEGLEITER JUSTIN; HATTERS DANNY; CURTIS JESSICA; CHEUNG KENNETH; KRISHNAN PREETHI; MITRA SIDDHARTHA; WIDJAJA KARTIKA; SHABY BENJAMIN A; LOTZ GREGOR P; NEWHOUSE YVONNE; MITCHELL EMILY J; OSMAND ALEX; GRAY MICHELLE; THULASIRAMIN VANITHA; SAUDOU FREDERIC; SEGAL MARK; YANG X WILLIAM; MASLIAH ELIEZER; THOMPSON LESLIE M; MUCHOWSKI PAUL J; WEISGRABER KARL H; FINKBEINER STEVEN,期刊：NATURE CHEMICAL BIOLOGY, 页码：318-318 , 文章类型： Correction，,卷期：2012年8-3] Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors (vol 7, pg 469, 2011) [作者：ADIBEKIAN ALEXANDER; MARTIN BRENT R; WANG CHU; HSU KULUNG; BACHOVCHIN DANIEL A; NIESSEN SHERRY; HOOVER HEATHER; CRAVATT BENJAMIN F,期刊：NATURE CHEMICAL BIOLOGY, 页码：318-318 , 文章类型： Correction，,卷期：2012年8-3] Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis [作者：KHARE SAGAR D; KIPNIS YAKOV; GREISEN PER JR; TAKEUCHI RYO; ASHANI YACOV; GOLDSMITH MOSHE; SONG YIFAN; GALLAHER JASMINE L; SILMAN ISRAEL; LEADER HAIM; SUSSMAN JOEL L; STODDARD BARRY L; TAWFIK DAN S; BAKER DAVID,期刊：NATURE CHEMICAL BIOLOGY, 页码：294-300 , 文章类型： Article，,卷期：2012年8-3] The ability to redesign enzymes to catalyze noncognate chemical transformations would have wide-ranging applications. We developed a computational method for repurposing the reactivity of metalloenzyme active site functi... PROTEIN DESIGN A metalloenzyme reloaded [作者：HOECKER BIRTE,期刊：NATURE CHEMICAL BIOLOGY, 页码：224-225 , 文章类型： News Item，,卷期：2012年8-3] ALTERNATIVE DNA STRUCTURES G4 DNA in cells: itae missa est? [作者：MERGNY JEANLOUIS,期刊：NATURE CHEMICAL BIOLOGY, 页码：225-226 , 文章类型： News Item，,卷期：2012年8-3] PROTEIN FOLDING Chaperoning protein evolution [作者：DE LOS RIOS PAOLO; GOLOUBINOFF PIERRE,期刊：NATURE CHEMICAL BIOLOGY, 页码：226-228 , 文章类型： News Item，,卷期：2012年8-3] BCR-ABL SIGNALING A new STATus in CML [作者：FABBRO DORIANO,期刊：NATURE CHEMICAL BIOLOGY, 页码：228-229 , 文章类型： News Item，,卷期：2012年8-3] HISTONE DEACETYLATION IP4 is an epigenetic coregulator [作者：KUTATELADZE TATIANA G,期刊：NATURE CHEMICAL BIOLOGY, 页码：230-231 , 文章类型： News Item，,卷期：2012年8-3]