个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis [作者：CHOU DANNY HUNGCHIEH; BODYCOMBE NICOLE E; CARRINSKI HYMAN A; LEWIS TIMOTHY A; CLEMONS PAUL A; SCHREIBER STUART L; WAGNER BRIDGET K,期刊：ACS CHEMICAL BIOLOGY, 页码：729-734 , 文章类型： Article，,卷期：2010年5-8] Pancreatic beta-cell apoptosis is a critical event during the development of type-1 diabetes. The identification of small molecules capable of preventing cytokine-induced apoptosis could lead to avenues for therapeutic i... ANS Binding Reveals Common Features of Cytotoxic Amyloid Species [作者：BOLOGNESI BENEDETTA; KUMITA JANET R; BARROS TERESA P; ESBJORNER ELIN K; LUHESHI LEILA M; CROWTHER DAMIAN C; WILSON MARK R; DOBSON CHRISTOPHER M; FAVRIN GIORGIO; YERBURY JUSTIN J,期刊：ACS CHEMICAL BIOLOGY, 页码：735-740 , 文章类型： Article，,卷期：2010年5-8] Oligomeric assemblies formed from a variety of disease-associated peptides and proteins have been strongly associated with toxicity in many neurodegenerative conditions, such as Alzheimer's disease. The precise nature of... Zinc Is Not Required for Activity of TPO Agonists Acting at the c-Mpl Receptor Transmembrane Domain [作者：ANDRADE JESSICA; CABLEWSKI TERESA; CONDIE GLENN; HAYLOCK DAVID; MEAGHER LAURENCE; RICHES ANDREW; TARASOVA ANNA; WERKMEISTER JEROME; WHITE JACINTA; WINKLER DAVID,期刊：ACS CHEMICAL BIOLOGY, 页码：741-745 , 文章类型： Article，,卷期：2010年5-8] Molecules that mimic the cytokine thrombopoietin that act by an atypical mechanism of binding to a receptor transmembrane (TM) domain are widely understood to require zinc for their biological activity. We investigated p... Potent Delivery of Functional Proteins into Mammalian Cells in Vitro and in Vivo Using a Supercharged Protein [作者：CRONICAN JAMES J; THOMPSON DAVID B; BEIER KEVIN T; MCNAUGHTON BRIAN R; CEPKO CONSTANCE L; LIU DAVID R,期刊：ACS CHEMICAL BIOLOGY, 页码：747-752 , 文章类型： Article，,卷期：2010年5-8] The inability of proteins to potently penetrate mammalian cells limits their usefulness as tools and therapeutics. When fused to superpositively charged GFP, proteins rapidly (within minutes) entered five different types... Probing Mechanism and Transition State of RNA Refolding [作者：FUERTIG BORIS; WENTER PHILIPP; PITSCH STEFAN; SCHWALBE HARALD,期刊：ACS CHEMICAL BIOLOGY, 页码：753-765 , 文章类型： Article，,卷期：2010年5-8] Kinetics and the atomic detail of RNA refolding are only poorly understood. It has been proposed that conformations with transient base pairing interaction are populated during RNA refolding, but a detailed description o... FMN Binding Site of Yeast NADPH-Cytochrome P450 Reductase Exposed at the Surface Is Highly Specific [作者：IVANOV ALEXIS S; GNEDENKO OKSANA V; MOLNAR ANDREY A; ARCHAKOV ALEXANDER I; PODUST LARISSA M,期刊：ACS CHEMICAL BIOLOGY, 页码：767-776 , 文章类型： Article，,卷期：2010年5-8] NADPH-cytochrome P450 reductase (CPR) transfers two reducing equivalents derived from NADPH via FAD and FMN to microsomal P450 monooxygenases in one-electron transfer steps. The crystal structure of yeast CPR (yCPR) cont... Site-Specific Orthogonal Labeling of the Carboxy Terminus of alpha-Tubulin [作者：BANERJEE ABHIJIT; PANOSIAN TIMOTHY D; MUKHERJEE KAMALIKA; RAVINDRA RUDRAVAJHALA; GAL SUSANNAH; SACKETT DAN L; BANE SUSAN,期刊：ACS CHEMICAL BIOLOGY, 页码：777-785 , 文章类型： Article，,卷期：2010年5-8] A fluorescent probe has been attached to the carboxy terminus of the a-subunit of alpha,beta-tubulin by an enzymatic reaction followed by a chemical reaction. The unnatural amino acid 3-formyltyrosine is attached to the ... Antifolate-Induced Depletion of Intracellular Glycine and Purines Inhibits Thymineless Death in E. coil [作者：KWON YUN KYUNG; HIGGINS MEYTAL B; RABINOWITZ JOSHUA D,期刊：ACS CHEMICAL BIOLOGY, 页码：787-795 , 文章类型： Article，,卷期：2010年5-8] Despite the therapeutic importance of antifolates, the links between their direct antimetabolite activity and downstream consequences remain incompletely understood. Here we employ metabolomics to examine the complete me... Replacing Mn2+ with Co2+ in Human Arginase I Enhances Cytotoxicity toward L-Arginine Auxotrophic Cancer Cell Lines (vol 5, pg 333, 2010) [作者：STONE EVERETT M; GLAZER EVAN S; CHANTRANUPONG LYNNE; CHERUKURI PAUL; BREECE ROBERT M; TIERNEY DAVID L; CURLEY STEVEN A; IVERSON BRENT L; GEORGIOU GEORGE,期刊：ACS CHEMICAL BIOLOGY, 页码：797-797 , 文章类型： Correction，,卷期：2010年5-8] Deep Impact: Scientific Evaluation by the Numbers [作者：MAHAPATRA ANIRBAN,期刊：ACS CHEMICAL BIOLOGY, 页码：715-717 , 文章类型： Editorial Material，,卷期：2010年5-8]