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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共9条记录   A Metabolic Alkene Reporter for Spatiotemporally Controlled Imaging of Newly Synthesized Proteins in Mammalian Cells [作者：SONG WENJIAO; WANG YIZHONG; YU ZHIPENG; VERA CLAUDIA I RIVERA; QU JUN; LIN QING,期刊：ACS CHEMICAL BIOLOGY, 页码：875-885 , 文章类型： Article，,卷期：2010年5-9] The nonsymmetrical spatial distribution of newly synthesized proteins in animal cells plays a central role in many cellular processes. Here, we report that a simple alkene tag, homoallylglycine (HAG), was co-translationa... Multicolor Monitoring of Dysregulated Protein Kinases in Chronic Myelogenous Leukemia [作者：WANG QUNZHAO; ZIMMERMAN ERIC I; TOUTCHKINE ATEXEI; MARTIN TIMOTHY D; GRAVES LEE M; LAWRENCE DAVID S,期刊：ACS CHEMICAL BIOLOGY, 页码：887-895 , 文章类型： Article，,卷期：2010年5-9] The Bcr-Abl and Lyn protein tyrosine kinases have been separately linked to the emergence of imatinib resistance in patients with chronic myelogenous leukemia. We have developed fluorescent sensors for these kinases that... Researchers in a Brave New Web 2.0 World [作者：MAHAPATRA ANIRBAN,期刊：ACS CHEMICAL BIOLOGY, 页码：799-800 , 文章类型： Editorial Material，,卷期：2010年5-9] Enhanced Antimicrobial Activity of Engineered Human Lysozyme [作者：SCANLON THOMAS C; TENEBACK CHARLOTTE C; GILL AVINASH; BEMENT JENNA L; WEINER JOSHUA A; LAMPPA JOHN W; LECLAIR LAURIE W; GRISWOLD KARL E,期刊：ACS CHEMICAL BIOLOGY, 页码：809-818 , 文章类型： Article，,卷期：2010年5-9] Lysozymes contain a disproportionately large fraction of cationic residues, and are thereby attracted toward the negatively charged surface of bacterial targets. Importantly, this conserved biophysical property may inhib... Critical Role of Membrane Cholesterol in Exocytosis Revealed by Single Platelet Study [作者：GE SHENCHENG; WHITE JAMES G; HAYNES CHRISTY L,期刊：ACS CHEMICAL BIOLOGY, 页码：819-828 , 文章类型： Article，,卷期：2010年5-9] Exocytosis is a fundamental cellular process, pivotal in a wide range of cell types, used to deliver chemical messengers from one cell to another cell or tissue. While a tremendous amount of knowledge has been gained in ... Mutagenesis of a Modular Polyketide Synthase Enoylreductase Domain Reveals Insights into Catalysis and Stereospecificity [作者：KWAN DAVID H; LEADLAY PETER F,期刊：ACS CHEMICAL BIOLOGY, 页码：829-838 , 文章类型： Article，,卷期：2010年5-9] Modular type I polyketide synthases (PKSs) such as the 6-deoxyerythronolide B synthase (DEBS) or the rapamycin synthase (RAPS) biosynthesize their polyketide products in a fashion similar to fatty acid biosynthesis. Each... Targeting Multifunctional Proteins by Virtual Screening: Structurally Diverse Cytohesin Inhibitors with Differentiated Biological Functions [作者：STUMPFE DAGMAR; BILL ANKE; NOVAK NINA; LOCH GERRIT; BLOCKUS HEIKE; GEPPERT HANNA; BECKER THOMAS; SCHMITZ ANTON; HOCH MICHAEL; KOLANUS WALDEMAR; FAMULOK MICHAEL; BAJORATH JUERGEN,期刊：ACS CHEMICAL BIOLOGY, 页码：839-849 , 文章类型： Article，,卷期：2010年5-9] Virtual screening (VS) of chemical libraries formatted in silico provides an alternative to experimental high-throughput screening (HTS) for the identification of small molecule modulators of protein function. We have ta... Engineering a Direct and Inducible Protein-RNA Interaction To Regulate RNA Biology [作者：BELMONT BRIAN J; NILES JACQUIN C,期刊：ACS CHEMICAL BIOLOGY, 页码：851-861 , 文章类型： Article，,卷期：2010年5-9] The importance and pervasiveness of naturally occurring regulation of RNA function in biology is increasingly being recognized. A common mechanism uses inducible protein RNA interactions to shape diverse aspects of cellu... Peptide Arrays Identify Isoform-Selective Substrates for Profiling Endogenous Lysine Deacetylase Activity [作者：GURARDLEVIN ZACHARY A; KILIAN KRISTOPHER A; KIM JOOHOON; BAEHR KATINKA; MRKSICH MILAN,期刊：ACS CHEMICAL BIOLOGY, 页码：863-873 , 文章类型： Article，,卷期：2010年5-9] This paper reports the development of a class of isoform-selective peptide substrates for measuring endogenous lysine deacetylase (KDAC) activities in cell culture. The peptides were first identified by comparing the sub...