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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共9条记录   Rational Conversion of Affinity Reagents into Label-Free Sensors for Peptide Motifs by Designed Allostery [作者：HUANG JIN; KOIDE SHOHEI,期刊：ACS CHEMICAL BIOLOGY, 页码：273-277 , 文章类型： Article，,卷期：2010年5-3] Optical biosensors for short peptide motifs, an important class of biomarkers, have been developed based on "affinity clamps", a new class of recombinant affinity reagents. Affinity clamps are engineered by linking a pep... Why Does Binding of Proteins to DNA or Proteins to Proteins Not Necessarily Spell Function? [作者：MA BUYONG; TSAI CHUNGJUNG; PAN YONGPING; NUSSINOV RUTH,期刊：ACS CHEMICAL BIOLOGY, 页码：265-272 , 文章类型： Article，,卷期：2010年5-3] Studies of binding are often question: first, is the observed binding functional, and second, if it is, which function? Is it activation or repression? The first question relates to binding at different sites; the second... Inhibition of DC-SIGN-Mediated HIV Infection by a Linear Trimannoside Mimic in a Tetravalent Presentation [作者：SATTIN SARA; DAGHETTI ANNA; THEPAUT MICHEL; BERZI ANGELA; SANCHEZNAVARRO MACARENA; TABARANI GEORGES; ROJO JAVIER; FIESCHI FRANCK; CLERICI MARIO; BERNARDI ANNA,期刊：ACS CHEMICAL BIOLOGY, 页码：301-312 , 文章类型： Article，,卷期：2010年5-3] HIV infection is pandemic in humans and is responsible for millions of deaths every year. The discovery of new cellular targets that can be used to prevent the infection process represents a new opportunity for developin... Chemical Probes of Surface Layer Biogenesis in Clostridium difficile [作者：DANG T H TAM; DE LA RIVA LUCIA; FAGAN ROBERT P; STORCK ELISABETH M; HEAL WILLIAM P; JANOIR CLAIRE; FAIRWEATHER NEIL F; TATE EDWARD W,期刊：ACS CHEMICAL BIOLOGY, 页码：279-285 , 文章类型： Article，,卷期：2010年5-3] Clostridium difficile, a leading cause of hospital-acquired infection, possesses a dense surface layer (S-layer) that mediates host-pathogen interactions. The key structural components of the S-layer result from proteoly... Chemical Biology Strategy Reveals Pathway-Selective Inhibitor of NF-kappa B Activation Induced by Protein Kinase C [作者：SHI RANXIN; RE DANIEL; DUDL ERIC; CUDDY MICHAEL; OKOTOTOWICZ KARL J; DAHL RUSSELL; SU YING; HURDER ANDREW; KITADA SHINICHI; PEDDIBHOTLA SATYAMAHESHWAR; ROTH GREGORY P; SMITH LAYTON H; KIPPS THOMAS J; COSFORD NICHOLAS; CASHMAN JOHN; REED JOHN C,期刊：ACS CHEMICAL BIOLOGY, 页码：287-299 , 文章类型： Article，,卷期：2010年5-3] Dysregulation of NF-kappa B activity contributes to many autoimmune and inflammatory diseases. At least nine pathways for NF-kappa B activation have been identified, most of which converge on the I kappa B kinases (IKKs)... Organic Linking [作者：SHAW JARED T; MCINTOSH MATT,期刊：ACS CHEMICAL BIOLOGY, 页码：255-256 , 文章类型： Editorial Material，,卷期：2010年5-3] no Replacing Mn2+ with Co2+ in Human Arginase I Enhances Cytotoxicity toward L-Arginine Auxotrophic Cancer Cell Lines [作者：STONE EVERETT M; GLAZER EVAN S; CHANTRANUPONG LYNNE; CHERUKURI PAUL; BREECE ROBERT M; TIERNEY DAVID L; CURLEY STEVEN A; IVERSON BRENT L; GEORGIOU GEORGE,期刊：ACS CHEMICAL BIOLOGY, 页码：333-342 , 文章类型： Article，,卷期：2010年5-3] Replacing the two Mn2+ ions normally present in human Arginase I with Co2+ resulted in a significantly lowered Km value without a concomitant reduction in k(cat). In addition, the pH dependence of the reaction was shifte... Light-Activated Gene Expression Directs Segregation of Co-cultured Cells in Vitro [作者：SAUERS DANIEL J; TEMBURNI MURALI K; BIGGINS JOHN B; CEO LUKE M; GALILEO DEN S; KOH JOHN T,期刊：ACS CHEMICAL BIOLOGY, 页码：313-320 , 文章类型： Article，,卷期：2010年5-3] Light-directed gene patterning methods have been described as a means to regulate gene expression in a spatially and temporally controlled manner. Several methods have been reported that use photocaged forms of small mol... Characterization of Plant-Derived Saponin Natural Products against Candida albicans [作者：COLEMAN JEFFREY J; OKOLI IKECHUKWU; TEGOS GEORGE P; HOLSON EDWARD B; WAGNER FLORENCE F; HAMBLIN MICHAEL R; MYLONAKIS ELEFTHERIOS,期刊：ACS CHEMICAL BIOLOGY, 页码：321-332 , 文章类型： Article，,卷期：2010年5-3] Candida albicans is an opportunistic fungal pathogen capable of life threatening disseminated infections particularly in immunocompromised patients. Resistance to many clinically used antifungal agents has created a need...