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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共9条记录   Binding of a Small Molecule at a Protein-Protein Interface Regulates the Chaperone Activity of Hsp70-Hsp40 [作者：WISEN SUSANNE; BERTELSEN ERIC B; THOMPSON ANDREA D; PATURY SRIKANTH; UNG PETER; CHANG LYRA; EVANS CHRISTOPHER G; WALTER GLADIS M; WIPF PETER; CARLSON HEATHER A; BRODSKY JEFFREY L; ZUIDERWEG ERIK R P; GESTWICKI JASON E,期刊：ACS CHEMICAL BIOLOGY, 页码：611-622 , 文章类型： Article，,卷期：2010年5-6] Heat shock protein 70 (Hsp70) is a highly conserved molecular chaperone that plays multiple roles in protein homeostasis. In these various tasks, the activity of Hsp70 is shaped by interactions with co-chaperones, such a... Lung Cancer - Genomics and Personalized Medicine [作者：MAHAPATRA ANIRBAN,期刊：ACS CHEMICAL BIOLOGY, 页码：529-531 , 文章类型： Editorial Material，,卷期：2010年5-6] no Gel Electrophoresis and X-ray Fluorescence: A Powerful Combination for the Analysis of Protein Metal Binding [作者：ZAHLER NATHAN H,期刊：ACS CHEMICAL BIOLOGY, 页码：541-543 , 文章类型： Article，,卷期：2010年5-6] Understanding the complex biochemical mechanisms that underlie the regulation, toxicity, and protein binding of metal ions requires the ability to analyze the metal content of individual proteins in complex mixtures. In ... Designed Proteins To Modulate Cellular Networks [作者：CORTAJARENA AITZIBER L; LIU TINA Y; HOCHSTRASSER MARK; REGAN LYNNE,期刊：ACS CHEMICAL BIOLOGY, 页码：545-552 , 文章类型： Article，,卷期：2010年5-6] A major challenge of protein design is to create useful new proteins that interact specifically with biological targets in living cells. Such binding modules have many potential applications, including the targeted pertu... Screening Libraries To Identify Proteins with Desired Binding Activities Using a Split-GFP Reassembly Assay [作者：JACKREL MEREDITH E; CORTAJARENA AITZIBER L; LIU TINA Y; REGAN LYNNE,期刊：ACS CHEMICAL BIOLOGY, 页码：553-562 , 文章类型： Article，,卷期：2010年5-6] Designer protein modules, which bind specifically to a desired target, have numerous potential applications. One approach to creating such proteins Is to construct and screen libraries. Here we present a detailed descrip... Imaging Metals in Proteins by Combining Electrophoresis with Rapid X-ray Fluorescence Mapping [作者：FINNEY LYDIA; CHISHTI YASMIN; KHARE TRIPTI; GIOMETTI CAROL; LEVINA AVIVA; LAY PETER A; VOGT STEFAN,期刊：ACS CHEMICAL BIOLOGY, 页码：577-587 , 文章类型： Article，,卷期：2010年5-6] Growing evidence points toward a very dynamic role for metals in biology. This suggests that physiological circumstance may mandate metal ion redistribution among ligands. This work addresses a critical need for technolo... Site-Activated Chelators Targeting Acetylcholinesterase and Monoamine Oxidase for Alzheimer's Therapy [作者：ZHENG HAILIN; YOUDIM MOUSSE B H; FRIDKIN MATI,期刊：ACS CHEMICAL BIOLOGY, 页码：603-610 , 文章类型： Article，,卷期：2010年5-6] Chelators have the potential to treat the underlying cause of Alzheimer's disease (AD), but their therapeutic use is hampered by their poor targeting and poor permeability to the brain and/or toxic effects. Here, we repo... Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237 [作者：SLOANE DOMINIC A; TRIKIC MICHAEL Z; CHU MATTHEW L H; LAMERS MARIA B A C; MASON CLIVE S; MUELLER ILKA; SAVORY WENDY J; WILLIAMS DAVID H; EYERS PATRICK A,期刊：ACS CHEMICAL BIOLOGY, 页码：563-576 , 文章类型： Article，,卷期：2010年5-6] The Aurora kinases regulate multiple aspects of mitotic progression, and their overexpression in diverse tumor types makes them appealing oncology targets. An intensive research effort over the past decade has led to the... Mutation of Archaeal Isopentenyl Phosphate Kinase Highlights Mechanism and Guides Phosphorylation of Additional Isoprenoid Monophosphates [作者：DELLAS NIKKI; NOEL JOSEPH P,期刊：ACS CHEMICAL BIOLOGY, 页码：589-601 , 文章类型： Article，,卷期：2010年5-6] The biosynthesis of isopentenyl diphosphate (IPP) from either the mevalonate (MVA) or the 1-deoxy-D-xylulose 5-phosphate (DXP) pathway provides the key metabolite for primary and secondary isoprenoid biosynthesis. Isopre...