ACS CHEMICAL BIOLOGY————————个性化文献订阅—

Natural Products as Chemical Probes
[作者：CARLSON ERIN E,期刊：ACS CHEMICAL BIOLOGY, 页码：639-653 , 文章类型： Article，,卷期：2010年5-7]
Natural products have evolved to encompass a broad spectrum of chemical and functional diversity. It is this diversity, along with their structural complexity, that enables nature's small molecules to target a nearly lim...

A Stereoelectronic Effect in Prebiotic Nucleotide Synthesis
[作者：CHOUDHARY AMIT; KAMER KIMBERLI J; POWNER MATTHEW W; SUTHERLAND JOHN D; RAINES RONALD T,期刊：ACS CHEMICAL BIOLOGY, 页码：655-657 , 文章类型： Article，,卷期：2010年5-7]
A plausible route for the spontaneous synthesis of an activated ribonucleotide that is poised for polymerization has been put forth (Powner et al. (2009) Nature, 459, 239-242). A key step in this route necessitates the r...

Douglas Weibel: Using Microfluidics for Microbiology
[作者：BROWNLEE CHRISTEN,期刊：ACS CHEMICAL BIOLOGY, 页码：633-637 , 文章类型： Article，,卷期：2010年5-7]
The ubiquity of microorganisms is unparalleled in any other known organism. These creatures surround our outsides and colonize our insides, a fact that has been known for centuries. However, despite their prevalence and ...

Exploiting a Global Regulator for Small Molecule Discovery in Photorhabdus luminescens
[作者：KONTNIK RENEE; CRAWFORD JASON M; CLARDY JON,期刊：ACS CHEMICAL BIOLOGY, 页码：659-665 , 文章类型： Article，,卷期：2010年5-7]
Bacterially produced small molecules demonstrate a remarkable range of structural and functional diversity and include some of our most useful biological probes and therapeutic agents. Annotations of bacterial genomes re...

Controlling Science
[作者：SEEBERGER PETER H,期刊：ACS CHEMICAL BIOLOGY, 页码：623-624 , 文章类型： Editorial Material，,卷期：2010年5-7]
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Intein-Mediated Cyclization of Randomized Peptides in the Periplasm of Escherichia coli and Their Extracellular Secretion
[作者：DESCHUYTENEER GENEVIEVE; GARCIA STEPHANIE; MICHIELS BENJAMIN; BAUDOUX BRUNO; DEGAND HERVE; MORSOMME PIERRE; SOUMILLION PATRICE,期刊：ACS CHEMICAL BIOLOGY, 页码：691-700 , 文章类型： Article，,卷期：2010年5-7]
Split-inteins can be used to generate backbone cyclized peptide as a source of new bioactive molecules. In this work we show that cysteine-mediated splicing can be performed in the oxidative environment of the periplasm ...

Proteomic and Mass Spectroscopic Quantitation of Protein S-Nitrosation Differentiates NO-Donors
[作者：SINHA VAISHALI; WIJEWICKRAMA GIHANI T; CHANDRASENA R ESALA P; XU HUA; EDIRISINGHE PRANEETH D; SCHIEFER ISAAC T; THATCHER GREGORY R J,期刊：ACS CHEMICAL BIOLOGY, 页码：667-680 , 文章类型： Article，,卷期：2010年5-7]
Protein S-nitrosation has been argued to be the most important signaling pathway mediating the bioactivity of NO. This post-translational modification of protein thiols is the result of chemical nitrosation of cysteine r...

Influence of Charge on Cell Permeability and Tumor Imaging of GPR30-Targeted In-111-Labeled Nonsteroidal Imaging Agents
[作者：NAYAK TAPAN K; DENNIS MEGAN K; RAMESH CHINNASAMY; BURAI RITWIK; ATCHER ROBERT W; SKLAR LARRY A; NORENBERG JEFFREY P; HATHAWAY HELEN J; ARTERBURN JEFFREY B; PROSSNITZ ERIC R,期刊：ACS CHEMICAL BIOLOGY, 页码：681-690 , 文章类型： Article，,卷期：2010年5-7]
Recent clinical studies implicate the role of G protein-coupled estrogen receptor, GPR30, in aggressive forms of breast, ovarian, and endometrial cancers. However, the functional role of GPR30 at cellular and molecular l...

Functional and Structural Analysis of a Key Region of the Cell Wall Inhibitor Moenomycin
[作者：FUSE SHINICHIRO; TSUKAMOTO HIROKAZU; YUAN YANQIU; WANG TSUNGSHING ANDREW; ZHANG YI; BOLLA MEGAN; WALKER SUZANNE; SLIZ PIOTR; KAHNE DANIEL,期刊：ACS CHEMICAL BIOLOGY, 页码：701-711 , 文章类型： Article，,卷期：2010年5-7]
Moenomycin A (MmA) belongs to a family of natural products that inhibit peptidoglycan biosynthesis by binding to the peptidoglycan glycosyltransferases, the enzymes that make the glycan chains of peptidoglycan. MmA is re...