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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Immunomodulatory activity of an anti-HSV-1 synthetic stigmastane analog [作者：MICHELINI FLAVIA M; ZORRILLA PILAR; ROBELLO CARLOS; ALCHE LAURA E,期刊：Bioorganic & Medicinal Chemistry, 页码：560-568 , 文章类型： Article，,卷期：2013年21-2] Many viral infections are associated with the development of immunopathologies and autoimmune diseases, which are of difficult treatment and for which no vaccines are yet available. Obtaining compounds that conjugate bot... Synthesis and in vitro biological evaluation of lipophilic cation conjugated photosensitizers for targeting mitochondria [作者：RAJAPUTRA PALLAVI; NKEPANG GREGORY; WATLEY RYAN; YOU YOUNGJAE,期刊：Bioorganic & Medicinal Chemistry, 页码：379-387 , 文章类型： Article，,卷期：2013年21-2] Mitochondria-specific photosensitizers were designed by taking advantage of the preferential localization of delocalized lipophilic cations (DLCs) in mitochondria. Three DLC-porphyrin conjugates: CMP-Rh (a core modified ... Design, synthesis and molecular docking of alpha,beta-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferative activity [作者：XU YUNYUN; CAO YI; MA HAILKUO; LI HUANQIU; AO GUIZHEN,期刊：Bioorganic & Medicinal Chemistry, 页码：388-394 , 文章类型： Article，,卷期：2013年21-2] A type of novel alpha,beta-unsaturated cyclohexanone analogous, which designed based on the curcumin core structure, have been discovered as potential EGFR inhibitors. These compounds exhibit potent antiproliferative act... Ferrocene tripeptide Gly-Pro-Arg conjugates: Synthesis and inhibitory effects on Alzheimer's A beta(1-42) fibrillogenesis and A beta-induced cytotoxicity in vitro [作者：ZHOU BINBIN; LI CHUNLAN; HAO YUANQIANG; JOHNNY MUYA CHABU; LIU YOUNIAN; LI JUAN,期刊：Bioorganic & Medicinal Chemistry, 页码：395-402 , 文章类型： Article，,卷期：2013年21-2] Alzheimer's disease (AD) is the most common cause of dementia, and currently there is no clinical treatment to cure it or to halt its progression. Aggregation and fibril formation of beta-amyloid peptides (A beta) are ce... Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymerase beta [作者：KURIYAMA ISOKO; MIYAZAKI ANNA; TSUDA YUKO; YOSHIDA HIROMI; MIZUSHINA YOSHIYUKI,期刊：Bioorganic & Medicinal Chemistry, 页码：403-411 , 文章类型： Article，,卷期：2013年21-2] The present study was designed to investigate the anticancer activity of novel nine small peptides (compounds 1-9) derived from TT-232, a somatostatin structural analogue, by analyzing the inhibition of mammalian DNA pol... Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety [作者：KONNO SHO; THANIGAIMALAI PILLAIYAR; YAMAMOTO TAKEHITO; NAKADA KIYOHIKO; KAKIUCHI RIE; TAKAYAMA KENTARO; YAMAZAKI YURI; YAKUSHIJI FUMIKA; AKAJI KENICHI; KISO YOSHIAKI; KAWASAKI YUKO; CHEN SHENEN; FREIRE ERNESTO; HAYASHI YOSHIO,期刊：Bioorganic & Medicinal Chemistry, 页码：412-424 , 文章类型： Article，,卷期：2013年21-2] We describe here the design, synthesis and biological evaluation of a series of molecules toward the development of novel peptidomimetic inhibitors of SARS-CoV 3CL(pro). A docking study involving binding between the init... Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis [作者：CSUK RENE; SCZEPEK RONNY; SIEWERT BIANKA; NITSCHE CHRISTOPH,期刊：Bioorganic & Medicinal Chemistry, 页码：425-435 , 文章类型： Article，,卷期：2013年21-2] Several novel betulin derivatives were prepared and evaluated for their antitumor activity. Among others, 3-O-acetylbetulinic aldehyde served as an ideal starting material for the synthesis of 28-acetylenic derivatives t... Synthesis and structure-activity relationships of 2-hydrazinyladenosine derivatives as A(2A) adenosine receptor ligands [作者：ELTAYEB ALI; GOLLOS SABRINA,期刊：Bioorganic & Medicinal Chemistry, 页码：436-447 , 文章类型： Article，,卷期：2013年21-2] A series of 2-hydrazinyladenosine derivatives was synthesized and investigated in radioligand binding studies for their affinity at the adenosine receptor subtypes with the goal to obtain potent and A(2A)AR selective ago... Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents [作者：WANG HAIHONG; QIU KEMING; CUI HONGEN; YANG YUSHUN; YINLUO; XING MAN; QIU XIAOYANG; BAI LIFEI; ZHU HAILIANG,期刊：Bioorganic & Medicinal Chemistry, 页码：448-455 , 文章类型： Article，,卷期：2013年21-2] A series of novel thiazolyl-pyrazoline derivatives containing benzodioxole (C1-C20) have been designed and synthesized. Among of the synthesized compounds, 2-(5-(benzo[d][1,3]dioxol-5-yl)-3-(4-bromophenyl)-4,5-dihydro-1H... New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) [作者：ORLANDI FRANCESCA; CORONNELLO MARCELLA; BELLUCCI CRISTINA; DEI SILVIA; GUANDALINI LUCA; MANETTI DINA; MARTELLI CECILIA; ROMANELLI MARIA NOVELLA; SCAPECCHI SERENA; SALERNO MILENA; MENIF HAYETTE; BELLO IVAN; MINI ENRICO; TEODORI ELISABETTA,期刊：Bioorganic & Medicinal Chemistry, 页码：456-465 , 文章类型： Article，,卷期：2013年21-2] As a continuation of previous research on a new series of potent and efficacious P-gp-dependent multidrug resistant (MDR) reversers with a N,N-bis(cyclohexanol) amine scaffold, we have designed and synthesized several an... Photoreactivities of 5-Bromouracil-containing RNAs [作者：MORINAGA HIRONOBU; KIZAKI SEIICHIRO; TAKENAKA TOMOHIRO; KANESATO SHUHEI; SANNOHE YUTA; TASHIRO RYU; SUGIYAMA HIROSHI,期刊：Bioorganic & Medicinal Chemistry, 页码：466-469 , 文章类型： Article，,卷期：2013年21-2] 5-Bromouracil (U-Br) was incorporated into three types of synthetic RNA and the products of the photoirradiated U-Br-containing RNAs were investigated using HPLC and MS analysis. The photoirradiation of r(GCA(Br)UGC)(2) ... Synthesis and biological evaluation of 4-hydroxy-4-(4-methoxyphenyl)-substituted proline and pyrrolidin-2-ylacetic acid derivatives as GABA uptake inhibitors [作者：ZHAO XUEQING; PABEL JOERG; HOEFNER GEORG C; WANNER KLAUS T,期刊：Bioorganic & Medicinal Chemistry, 页码：470-484 , 文章类型： Article，,卷期：2013年21-2] A series of enantiomerically pure 4-hydroxy-4-(4-methoxyphenyl)-substituted proline and pyrrolidin-2-ylacetic acid derivatives have been synthesized starting from the respective N-protected 4-hydroxy derivatives via oxid... Synthesis and cellular studies of polyamine conjugates of a mercaptomethyl-carboranylporphyrin [作者：BHUPATHIRAJU N V S DINESH K; GRACA M; VICENTE H,期刊：Bioorganic & Medicinal Chemistry, 页码：485-495 , 文章类型： Article，,卷期：2013年21-2] Seven polyamine conjugates of a tri(p-carboranylmethylthio)tetrafluorophenylporphyrin were prepared in high yields by sequential substitution of the p-phenyl fluoride of tetrakis(pentafluorophenyl) porphyrin (TPPF), and ... Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression [作者：HOLLAND JASON P; JONES MICHAEL W; COHRS SUSAN; SCHIBLI ROGER; FISCHER ELIANE,期刊：Bioorganic & Medicinal Chemistry, 页码：496-507 , 文章类型： Article，,卷期：2013年21-2] Anti-mitotic anti-cancer drugs offer a potential platform for developing new radiotracers for imaging proliferation markers associated with the mitosis-phase of the cell-cycle. One interesting target is kinesin spindle p... Fluorescence 'on-off-on' chemosensor for sequential recognition of Fe3+ and Hg2+ in water based on tetraphenylethylene motif [作者：YAN YUANYUAN; CHE ZHIPING; YU XIANG; ZHI XIAOYAN; WANG JUANJUAN; XU HUI,期刊：Bioorganic & Medicinal Chemistry, 页码：508-513 , 文章类型： Article，,卷期：2013年21-2] A novel selective and sensitive fluorescence 'on-off-on' probe based on tetraphenylethylene (TPE) motif for sequential recognition of Fe3+ and Hg2+ in water has been developed. Especially the complex 6-Fe3+ could behave ... Synthesis and preliminary evaluation of pharmacological properties of some piperazine derivatives of xanthone [作者：SZKARADEK NATALIA; RAPACZ ANNA; PYTKA KAROLINA; FILIPEK BARBARA; SIWEK AGATA; CEGLA MAREK; MARONA HENRYK,期刊：Bioorganic & Medicinal Chemistry, 页码：514-522 , 文章类型： Article，,卷期：2013年21-2] A series of 9 piperazine derivatives of xanthone were synthesized and evaluated for cardiovascular activity. The following pharmacological experiments were conducted: the binding affinity for adrenoceptors, the influence...