- N-Acetyl lysyl-tRNA synthetases evolved by a CcdB-based selection possess N-acetyl lysine specificity in vitro and in vivo
[作者:Umehara, T; Kim, J; Lee, S; Guo, LT; Soll, D; Park, HS,期刊:FEBS Letters, 页码:729-733 , 文章类型: Article,,卷期:2012年586-6]
- Posttranslational modifications play a crucial role in modulating protein structure and function. Genetic incorporation of unnatural amino acids into a specific site of a protein facilitates the systematic study of prote...
- Crystal structure of a single-chain trimer of human adiponectin globular domain
[作者:Min, XS; Lemon, B; Tang, J; Liu, Q; Zhang, R; Walker, N; Li, Y; Wang, ZL,期刊:FEBS Letters, 页码:912-917 , 文章类型: Article,,卷期:2012年586-6]
- Adiponectin is increasingly recognized as a potential therapeutic agent for the treatment of diabetes and other metabolic diseases. It circulates in plasma as homotrimers and higher-order oliogomers of homotrimers. To fa...
- Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6
[作者:Cai, Y; Yu, SS; Chen, SR; Pi, RBA; Gao, S; Li, H; Ye, JT; Liu, PQ,期刊:FEBS Letters, 页码:866-874 , 文章类型: Article,,卷期:2012年586-6]
- The discovery of sirtuins (SIRT), a family of nicotinamide adenine dinucleotide (NAD)-dependent deacetylases, has indicated that intracellular NAD level is crucial for the hypertrophic response of cardiomyocytes. Nicotin...
- OIT3 deficiency impairs uric acid reabsorption in renal tubule
[作者:Yan, B; Zhang, ZZ; Huang, LY; Shen, HL; Han, ZG,期刊:FEBS Letters, 页码:760-765 , 文章类型: Article,,卷期:2012年586-6]
- The oncoprotein induced transcript 3 (OIT3), also named liver-specific zona pellucida domain-containing protein (LZP), has been shown to be expressed in kidney, and was confirmed to interact with the Tamm-Horsfall glycop...
- Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins
[作者:Adams-Cioaba, MA; Li, ZH; Tempel, W; Guo, YH; Bian, CB; Li, YJ; Lam, R; Min, JR,期刊:FEBS Letters, 页码:859-865 , 文章类型: Article,,卷期:2012年586-6]
- The human PHD finger protein 20 (PHF20) is a putative transcription factor. While little is known about its cognate cellular role, antibodies against PHF20 are present in sera from patients with hepatocellular carcinoma,...
- Overexpression of lalA, a paralog of labA, is capable of affecting both circadian gene expression and cell growth in the cyanobacterium Synechococcus elongatus PCC 7942
[作者:Taniguchi, Y; Nishikawa, T; Kondo, T; Oyama, T,期刊:FEBS Letters, 页码:753-759 , 文章类型: Article,,卷期:2012年586-6]
- In the cyanobacterium Synechococcus elongatus, LabA negatively regulates circadian gene expression under the control of Kai-protein-based clock. Here we conducted a molecular genetic analysis of lalA, a paralog of labA. ...
- Prediction of replication origins by calculating DNA structural properties
[作者:Chen, W; Feng, PMA; Lin, H,期刊:FEBS Letters, 页码:934-938 , 文章类型: Article,,卷期:2012年586-6]
- In this study, we introduced two DNA structural characteristics, namely, bendability and hydroxyl radical cleavage intensity to analyze origin of replication (ORI) in the Saccharomyces cerevisiae genome. We found that bo...
- Rational design of DNA sequence-specific zinc fingers
[作者:Kono, H; Imanishi, M; Negi, S; Tatsutani, K; Sakaeda, Y; Hashimoto, A; Nakayama, C; Futaki, S; Sugiura, Y,期刊:FEBS Letters, 页码:918-923 , 文章类型: Article,,卷期:2012年586-6]
- We developed a rational scheme for designing DNA binding proteins. The scheme was applied for a zinc finger protein and the designed sequences were experimentally characterized with high DNA sequence specificity. Startin...
- Formation of amyloid fibrils from beta-amylase
[作者:Luo, JC; Wang, SC; Jian, WB; Chen, CH; Tang, JL; Lee, CI,期刊:FEBS Letters, 页码:680-685 , 文章类型: Article,,卷期:2012年586-6]
- Fibril formation has been considered a significant feature of amyloid proteins. However, it has been proposed that fibril formation is a common property of many proteins under appropriate conditions. We studied the fibri...
- Requirement for Pak3 in Rac1-induced organization of actin and myosin during Drosophila larval wound healing
[作者:Baek, SH; Cho, HW; Kwon, YC; Lee, JH; Kim, MJ; Lee, H; Choe, KM,期刊:FEBS Letters, 页码:772-777 , 文章类型: Article,,卷期:2012年586-6]
- Rho-family small GTPases regulate epithelial cell sheet migration by organizing actin and myosin during wound healing. Here, we report that Pak3, but not Pak1, is a downstream target protein for Rac1 in wound closure of ...
- HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-kappa B signaling to protect breast cancer cells from complement attack
[作者:Cui, WJ; Zhao, Y; Shan, CL; Kong, GY; Hu, N; Zhang, YW; Zhang, S; Zhang, WY; Zhang, YY; Zhang, XD; Ye, LH,期刊:FEBS Letters, 页码:766-771 , 文章类型: Article,,卷期:2012年586-6]
- Hepatitis B X-interacting protein (HBXIP) is able to enhance migration of breast cancer cells. However, the role of HBXIP in regulation of complement-dependent cytotoxicity (CDC) in breast cancer is not understood. Here,...
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