- Epigenetic regulation of cancer growth by histone demethylases
[作者:Lim, S; Metzger, E; Schule, R; Kirfel, J; Buettner, R,期刊:International Journal of Cancer, 页码:1991-1998 , 文章类型: Review,,卷期:2010年127-9]
- Cancer is traditionally viewed as a primarily genetic disorder. However, it is now increasingly apparent that epigenetic abnormalities play a fundamental role in cancer development. Aberrant expression of histone-modifyi...
- Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration
[作者:An, ZW; Dobra, K; Lock, JG; Stromblad, S; Hjerpe, A; Zhang, HQ,期刊:International Journal of Cancer, 页码:1999-2008 , 文章类型: Article,,卷期:2010年127-9]
- Kindlin-2 is a novel integrin-interacting focal adhesion protein that belongs to the Kindlin family. Focal adhesion proteins control cytoskeleton dynamics and promote cancer cell growth, survival, migration and metastasi...
- Exogenous luminal nitric oxide exposure accelerates columnar transformation of rat esophagus
[作者:Endo, H; Iijima, K; Asanuma, K; Ara, N; Ito, H; Asano, N; Uno, K; Koike, T; Imatani, A; Shimosegawa, T,期刊:International Journal of Cancer, 页码:2009-2019 , 文章类型: Article,,卷期:2010年127-9]
- Exposure of the esophageal mucosa to refluxed gastroduodenal contents is recognized to be an important risk factor for Barrett's esophagus (BE). At the human gastroesophageal junction, nitric oxide is generated luminally...
- CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide
[作者:Sharma, PK; Singh, R; Novakovic, KR; Eaton, JW; Grizzle, WE; Singh, S,期刊:International Journal of Cancer, 页码:2020-2030 , 文章类型: Article,,卷期:2010年127-9]
- Despite recent advances in treatment and management of prostate cancer (PCa), it remains the second leading cause of cancer-related deaths among men in the US. Chemotherapy is one of the treatment alternatives for hormon...
- Intraepithelial p63-dependent expression of distinct components of cell adhesion complexes in normal esophageal mucosa and squamous cell carcinoma
[作者:Thepot, A; Hautefeuille, A; Cros, MP; Abedi-Ardekani, B; Petre, A; Damour, O; Krutovskikh, V; Hainaut, P,期刊:International Journal of Cancer, 页码:2051-2062 , 文章类型: Article,,卷期:2010年127-9]
- TP63 gene is a member of TP53 tumor suppressor gene family that encodes several protein isoforms involved in the process of epithelial stratification and in epithelial-mesenchyme interactions. TP63 is amplified in a sign...
- Tumor-specific mutation and downregulation of ING5 detected in oral squamous cell carcinoma
[作者:Cengiz, B; Gunduz, E; Gunduz, M; Beder, LB; Tamamura, R; Bagci, C; Yamanaka, N; Shimizu, K; Nagatsuka, H,期刊:International Journal of Cancer, 页码:2088-2094 , 文章类型: Article,,卷期:2010年127-9]
- Our previous study showed high frequency of allelic loss at chromosome 2q37 region in oral cancer. This location contains several candidate tumor suppressor genes such as PPP1R7, ILKAP, DTYMK and ING5. We previously show...
- Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers
[作者:An, B; Kondo, Y; Okamoto, Y; Shinjo, K; Kanemitsu, Y; Komori, K; Hirai, T; Sawaki, A; Tajika, M; Nakamura, T; Yamao, K; Yatabe, Y; Fujii, M; Murakami, H; Osada, H; Tani, T; Matsuo, K; Shen, L; Issa, JPJ; Sekido, Y,期刊:International Journal of Cancer, 页码:2095-2105 , 文章类型: Article,,卷期:2010年127-9]
- Aberrant DNA methylation is involved in colon carcinogenesis. Although the CpG island methylator phenotype (CIMP) is defined as a subset of colorectal cancers (CRCs) with remarkably high levels of DNA methylation, it is ...
- MGMT activity, promoter methylation and immunohistochemistry of pretreatment and recurrent malignant gliomas: a comparative study on astrocytoma and glioblastoma
[作者:Christmann, M; Nagel, G; Horn, S; Krahn, U; Wiewrodt, D; Sommer, C; Kaina, B,期刊:International Journal of Cancer, 页码:2106-2118 , 文章类型: Article,,卷期:2010年127-9]
- The DNA repair protein O-6-methylguanine-DNA methyltransferase (MGMT) is a key player in tumor cell resistance. Promoter methylation, MGMT activity and immunohistochemistry are used for determining the MGMT status. Howev...
- The BCR/ABL-inhibitors Imatinib, Nilotinib and Dasatinib differentially affect NK cell reactivity
[作者:Salih, J; Hilpert, J; Placke, T; Grunebach, F; Steinle, A; Salih, HR; Krusch, M,期刊:International Journal of Cancer, 页码:2119-2128 , 文章类型: Article,,卷期:2010年127-9]
- In chronic myeloid leukemia (CML), BCR/ABL-mediated oncogenic signaling can be targeted with the BCR/ABL-inhibitors Imatinib, Nilotinib and Dasatinib. However, these agents may also affect anti-tumor immunity. Here, we a...
- In vivo tumor suppression activity by T cell-specific T-bet restoration
[作者:Lee, K; Min, HJ; Jang, EJ; Hong, JH; Hwang, ES,期刊:International Journal of Cancer, 页码:2129-2137 , 文章类型: Article,,卷期:2010年127-9]
- T-box-containing protein expressed in T cells (T-bet) is a master transcription factor for the development of interferon (IFN) gamma-producing T helper 1 (Th1) cells, and also functions in other immune cells including na...
- Plasma decorin predicts the presence of esophageal squamous cell carcinoma
[作者:Wu, IC; Wu, DC; Huang, CC; Lin, HS; Chen, YK; Tsai, HJ; Lu, CY; Chou, SH; Chou, YP; Li, LH; Tai, SY; Wu, MT,期刊:International Journal of Cancer, 页码:2138-2146 , 文章类型: Article,,卷期:2010年127-9]
- Using a microarray technique, we found decorin to be underexpressed, but osteopontin (OPN) to be overexpressed, in esophageal squamous cell carcinoma (ESCC). This study aims to examine whether plasma decorin and OPN plus...
- The health and economic effects of HPV DNA screening in the Netherlands
[作者:Berkhof, J; Coupe, VM; Bogaards, JA; van Kemenade, FJ; Helmerhorst, TJ; Snijders, PJ; Meijer, CJ,期刊:International Journal of Cancer, 页码:2147-2158 , 文章类型: Article,,卷期:2010年127-9]
- We studied the health and economic effects of human papillomavirus (HPV) DNA testing in cervical screening using a simulation model. The key data source was a Dutch longitudinal screening trial. We compared cytological t...
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