- Adenosine 5 '-phosphosulfate reductase (APR2) mutation in Arabidopsis implicates glutathione deficiency in selenate toxicity
[作者:Grant, K; Carey, NM; Mendoza, M; Schulze, J; Pilon, M; Pilon-Smits, EAH; Van Hoewyk, D,期刊:Biochemical Journal, 页码:325-335 , 文章类型: Article,,卷期:2011年438-2]
- APR2 is the dominant APR (adenosine 5'-phosphosulfate reductase) in the model plant Arabidopsis thaliana, and converts activated sulfate to sulfite, a key reaction in the sulfate reduction pathway. To determine whether A...
- Ca(2+)-induced PARP-1 activation and ANF expression are coupled events in cardiomyocytes
[作者:Geistrikh, I; Visochek, L; Klein, R; Miller, L; Mittelman, L; Shainberg, A; Cohen-Armon, M,期刊:Biochemical Journal, 页码:337-347 , 文章类型: Article,,卷期:2011年438-2]
- The nuclear protein PARP-1 [poly(ADP-ribose) polymerase-1] is activated in cardiomyocytes exposed to hypoxia causing DNA breaks. Unlike this stress-induced PARP-1 activation, our results provide evidence for Ca(2+)-induc...
- Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis
[作者:Botham, A; Guo, XD; Xiao, YP; Morice, AH; Compton, SJ; Sadofsky, LR,期刊:Biochemical Journal, 页码:359-367 , 文章类型: Article,,卷期:2011年438-2]
- hPAR(2) (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors). Previous pharmacological stud...
- Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress
[作者:Agouni, A; Mody, N; Owen, C; Czopek, A; Zimmer, D; Bentires-Alj, M; Bence, KK; Delibegovic, M,期刊:Biochemical Journal, 页码:369-378 , 文章类型: Article,,卷期:2011年438-2]
- Obesity is associated with induction of the ER (endoplasmic reticulum)-stress response signalling and insulin resistance. PTP1B (protein tyrosine phosphatase 1B) is a major regulator of adiposity and insulin sensitivity....
- Position-dependent attenuation by Kv1.6 of N-type inactivation of Kv1.4-containing channels
[作者:Al-Sabi, A; Kaza, S; Le Berre, M; O'Hara, L; Bodeker, M; Wang, JF; Dolly, JO,期刊:Biochemical Journal, 页码:389-396 , 文章类型: Article,,卷期:2011年438-2]
- Assembly of distinct alpha subunits of Kv1 (voltage-gated K(+) channels) into tetramers underlies the diversity of their outward currents in neurons. Kv1.4-containing channels normally exhibit N-type rapid inactivation, ...
- Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities
[作者:Birkholtz, LM; Williams, M; Niemand, J; Louw, AI; Persson, L; Heby, O,期刊:Biochemical Journal, 页码:229-244 , 文章类型: Review,,卷期:2011年438-2]
- New drugs are urgently needed for the treatment of tropical and subtropical parasitic diseases, such as African sleeping sickness. Chagas' disease, leishmaniasis and malaria. Enzymes in polyamine biosynthesis and thiol m...
- Crystal structure of the glutamate receptor GluA1 N-terminal domain
[作者:Yao, GR; Zong, YN; Gu, SY; Zhou, J; Xu, HX; Mathews, II; Jin, RS,期刊:Biochemical Journal, 页码:255-263 , 文章类型: Article,,卷期:2011年438-2]
- The AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) subfamily of iGluRs (ionotropic glutamate receptors) is essential for fast excitatory neurotransmission in the central nervous system. The malfunction o...
- Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin
[作者:East, DA; Sousa, D; Martin, SR; Edwards, TA; Lehman, W; Mulvihill, DP,期刊:Biochemical Journal, 页码:265-273 , 文章类型: Article,,卷期:2011年438-2]
- Tm (tropomyosin) is an evolutionarily conserved alpha-helical coiled-coil protein, dimers of which form end-to-end polymers capable of associating with and stabilizing actin filaments, and regulating myosin function. The...
- Catalytic properties of the Gas family beta-(1,3)-glucanosyltransferases active in fungal cell-wall biogenesis as determined by a novel fluorescent assay
[作者:Mazan, M; Ragni, E; Popolo, L; Farkas, V,期刊:Biochemical Journal, 页码:275-282 , 文章类型: Article,,卷期:2011年438-2]
- BGTs [beta-(1,3)-glucanosyltransglycosylases; EC 2.4.1.-] of the GH72 (family 72 of glycosylhydrolases) are GPI (glycosylphosphatidylinositol)-anchored proteins that play an important role in the biogenesis of fungal cel...
- ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis
[作者:Li, HK; Meng, QS; Xiao, F; Chen, SH; Du, Y; Yu, JJ; Wang, CX; Guo, FF,期刊:Biochemical Journal, 页码:283-289 , 文章类型: Article,,卷期:2011年438-2]
- Chronic feeding of HCD (high-carbohydrate diet) is one of the major contributors to the prevailing of metabolic diseases. ATF4 (activating transcription factor 4) has been shown to play an important role in the regulatio...
- Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL
[作者:Ambrosi, E; Capaldi, S; Bovi, M; Saccomani, G; Perduca, M; Monaco, HL,期刊:Biochemical Journal, 页码:291-301 , 文章类型: Article,,卷期:2011年438-2]
- The SOUL protein is known to induce apoptosis by provoking the mitochondrial permeability transition, and a sequence homologous with the BH3 (Bcl-2 homology 3) domains has recently been identified in the protein, thus ma...
- Molecular diversity of the Trypanosoma cruzi TcSMUG family of mucin genes and proteins
[作者:Urban, I; Santurio, LB; Chidichimo, A; Yu, H; Chen, X; Mucci, J; Aguero, F; Buscaglia, CA,期刊:Biochemical Journal, 页码:303-313 , 文章类型: Article,,卷期:2011年438-2]
- The surface of the protozoan Trypanosoma cruzi is covered by a dense coat of mucin-type glycoconjugates, which make a pivotal contribution to parasite protection and host immune evasion. Their importance is further under...
- Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage
[作者:Lian, F; Xing, XB; Yuan, G; Schafer, C; Rauser, S; Walch, A; Rocken, C; Ebeling, M; Wright, MB; Schmid, RM; Ebert, MPA; Burgermeister, E,期刊:Biochemical Journal, 页码:315-323 , 文章类型: Article,,卷期:2011年438-2]
- Bile acids from duodenogastric reflux promote inflammation and increase the risk for gastro-oesophageal cancers. FXR (farnesoid X receptor/NR1H4) is a transcription factor regulated by bile acids such as CDCA (chenodeoxy...
|