- In VIVO biochemistry: quantifying ion and metabolite levels in individual cells or cultures of yeast
[作者:Bermejo, C; Ewald, JC; Lanquar, V; Jones, AM; Frommer, WB,期刊:Biochemical Journal, 页码:1-10 , 文章类型: Review,,卷期:2011年438-Part 1]
- Over the past decade, we have learned that cellular processes, including signalling and metabolism, are highly compartmentalized, and that relevant changes in metabolic state can occur at sub-second timescales. Moreover,...
- Targeting the autolysis loop of urokinase-type plasminogen activator with conformation-specific monoclonal antibodies
[作者:Botkjaer, KA; Fogh, S; Bekes, EC; Chen, Z; Blouse, GE; Jensen, JM; Mortensen, KK; Huang, MD; Deryugina, E; Quigley, JP; Declerck, PJ; Andreasen, PA,期刊:Biochemical Journal, 页码:39-51 , 文章类型: Article,,卷期:2011年438-Part 1]
- Tight regulation of serine proteases is essential for their physiological function, and unbalanced states of protease activity have been implicated in a variety of human diseases. One key example is the presence of uPA (...
- A drug targeting only p110 alpha can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types
[作者:Jamieson, S; Flanagan, JU; Kolekar, S; Buchanan, C; Kendall, JD; Lee, WJ; Rewcastle, GW; Denny, WA; Singh, R; Dickson, J; Baguley, BC; Shepherd, PR,期刊:Biochemical Journal, 页码:53-62 , 文章类型: Article,,卷期:2011年438-Part 1]
- Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted on chromosome 10), amplifications of PIK3CA and mutations in...
- Aldo-keto reductase family 1, member B10 is secreted through a lysosome-mediated non-classical pathway
[作者:Luo, DX; Huang, MC; Ma, J; Gao, Z; Liao, DF; Cao, DL,期刊:Biochemical Journal, 页码:71-80 , 文章类型: Article,,卷期:2011年438-Part 1]
- AKR1B10 (aldo-keto reductase family 1, member B10) protein is primarily expressed in normal human small intestine and colon, but overexpressed in several types of human cancers and considered as a tumour marker. In the p...
- Exo70, a subunit of the exocyst complex, interacts with SNEVhPrp19/hPso4 and is involved in pre-mRNA splicing
[作者:Dellago, H; Loscher, M; Ajuh, P; Ryder, U; Kaisermayer, C; Grillari-Voglauer, R; Fortschegger, K; Gross, S; Gstraunthaler, A; Borth, N; Eisenhaber, F; Lamond, AI; Grillari, J,期刊:Biochemical Journal, 页码:81-91 , 文章类型: Article,,卷期:2011年438-Part 1]
- The Cdc5L (cell division cycle 5-like) complex is a spliceosomal subcomplex that also plays a role in DNA repair. The complex contains the splicing factor hPrp19, also known as SNEV or hPso4, which is involved in cellula...
- Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPAR gamma agonist
[作者:Goto, T; Nagai, H; Egawa, K; Kim, YI; Kato, S; Taimatsu, A; Sakamoto, T; Ebisu, S; Hohsaka, T; Miyagawa, H; Murakami, S; Takahashi, N; Kawada, T,期刊:Biochemical Journal, 页码:111-119 , 文章类型: Article,,卷期:2011年438-Part 1]
- The cholesterol biosynthetic pathway produces not only sterols but also non-sterol mevalonate metabolites involved in isoprenoid synthesis. Mevalonate metabolites affect transcriptional and post-transcriptional events th...
- Protein network study of human AF4 reveals its central role in RNA Pol II-mediated transcription and in phosphorylation-dependent regulatory mechanisms
[作者:Esposito, G; Cevenini, A; Cuomo, A; De Falco, F; Sabbatino, D; Pane, F; Ruoppolo, M; Salvatore, F,期刊:Biochemical Journal, 页码:121-131 , 文章类型: Article,,卷期:2011年438-Part 1]
- AF4 belongs to a family of proteins implicated in childhood lymphoblastic leukaemia, FRAXE (Fragile X E site) mental retardation and ataxia. AF4 is a transcriptional activator that is involved in transcriptional elongati...
- Demonstration that endoplasmic reticulum-associated degradation of glycoproteins can occur downstream of processing by endomannosidase
[作者:Kukushkin, NV; Alonzi, DS; Dwek, RA; Butters, TD,期刊:Biochemical Journal, 页码:133-142 , 文章类型: Article,,卷期:2011年438-Part 1]
- During quality control in the ER (endoplasmic reticulum), nascent glycoproteins are deglucosylated by ER glucosidases I and II. In the post-ER compartments, glycoprotein endo-alpha-mannosidase provides an alternative rou...
- OEP61 is a chaperone receptor at the plastid outer envelope
[作者:von Loeffelholz, O; Kriechbaumer, V; Ewan, RA; Jonczyk, R; Lehmann, S; Young, JC; Abell, BM,期刊:Biochemical Journal, 页码:143-153 , 文章类型: Article,,卷期:2011年438-Part 1]
- Chloroplast precursor proteins encoded in the nucleus depend on their targeting sequences for delivery to chloroplasts. There exist different routes to the chloroplast outer envelope, but a common theme is the involvemen...
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