- Ulcerative colitis is a disease of accelerated colon aging: Evidence from telomere attrition and DNA damage
[作者：Risques, RA; Lai, LA; Brentnall, TA; Li, L; Feng, ZD; Gallaher, J; Mandelson, MT; Potter, JD; Bronner, MP; Rabinovitch, PS,期刊：Gastroenterology, 页码：410-418 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: Telomere shortening is implicated in cancer and aging and might link these 2 biologic events. We explored this hypothesis in ulcerative colitis (UC), a chronic inflammatory disease that predisposes to ...
- The clinical phenotype of Lynch syndrome due to germ-line PMS2 mutations
[作者：Senter, L; Clendenning, M; Sotamaa, K; Hampel, H; Green, J; Potter, JD; Lindblom, A; Lagerstedt, K; Thibodeau, SN; Lindor, NM; Young, J; Winship, I; Dowty, JG; White, DM; Hopper, JL; Baglietto, L; Jenkins, MA; de la Chaple, A,期刊：Gastroenterology, 页码：419-428 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: Although the clinical phenotype of Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer) has been well described, little is known about disease in PMS2 mutation carriers. Now that mu...
- Identification of EpCAM as the gene for congenital tufting enteropathy
[作者：Sivagnanam, M; Mueller, JL; Lee, H; Chen, Z; Nelson, SF; Turner, D; Zlotkin, SH; Pencharz, PB; Ngan, BY; Libiger, O; Schork, NJ; Lavine, JE; Taylor, S; Newbury, RO; Kolodner, RD; Hoffman, HM,期刊：Gastroenterology, 页码：429-437 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: Congenital tufting enteropathy (CTE) is a rare autosomal recessive diarrheal disorder presenting in the neonatal period. CTE is characterized by intestinal epithelial cell dysplasia leading to severe m...
- Peginterferon alfa-2a and ribavirin for 24 weeks in hepatitis C type 1 and 4 patients with rapid virological response
[作者：Ferenci, P; Laferl, H; Scherzer, TM; Gschwantler, M; Maieron, A; Brunner, H; Stauber, R; Bischof, M; Bauer, B; Datz, C; Loschenberger, K; Formann, E; Staufer, K; Steindl-Munda, P,期刊：Gastroenterology, 页码：451-458 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: This analysis reports the rate of sustained virological response (SVR) in patients infected with hepatitis C virus (HCV) genotype I or 4 who were assigned to 24 weeks of treatment with pegylated interf...
- Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells
[作者：Wendt, MK; Drury, LJ; Vongsa, RA; Dwinell, MB,期刊：Gastroenterology, 页码：508-517 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: CXCL12 and CXCR4 signaling plays critical roles in development, homeostasis, and tumor metastasis. Previously, we have shown that epigenetic silencing of CXCL12 in colorectal. and mammary carcinomas pr...
- Sustained HBeAg and HBsAg loss after long-term follow-up of HBeAg-positive patients treated with peginterferon alpha-2b
[作者：Buster, EHCJ; Flink, HJ; Cakaloglu, Y; Simon, K; Trojan, J; Tabak, F; So, TMK; Feinman, SV; Mach, T; Akarca, US; Schutten, M; Tielemans, W; Van Vuuren, AJ; Hansen, BE; Janssen, HLA,期刊：Gastroenterology, 页码：459-467 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: The aim of this study was to evaluate the long-term sustainability of response in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B treated with pegylated interferon (PEG-IFN) al...
- Donor morbidity after living donation for liver transplantation
[作者：Ghobrial, RM; Freise, CE; Trotter, JF; Tong, L; Ojo, AO; Fair, JH; Fisher, RA; Emond, JC; Koffron, AJ; Pruett, TL; Olthoff, KM,期刊：Gastroenterology, 页码：468-476 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: Reports of complications among adult right hepatic lobe donors have been limited to single centers. The rate and severity of complications in living donors were investigated in the 9-center Adult-to-Ad...
- His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk
[作者：Ohnami, S; Sato, Y; Yoshimura, K; Ohnami, S; Sakamoto, H; Aoki, K; Ueno, H; Ikeda, M; Morizane, C; Shimada, K; Sakamoto, Y; Esaki, M; Saito, I; Hirose, H; Saito, D; Sugimura, H; Kosuge, T; Okusaka, T; Yoshida, T,期刊：Gastroenterology, 页码：477-488 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: This study attempts to elucidate a part of the genetic predisposition to the sporadic invasive ductal adenocarcinoma of the pancreas focusing on the genes implicated in the gene-environment interaction...
- Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients
[作者：Diehl, F; Schmidt, K; Durkee, KH; Moore, KJ; Goodman, SN; Shuber, AP; Kinzler, KW; Vogelstein, B,期刊：Gastroenterology, 页码：489-498 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: Somatic mutations provide uniquely specific markers for the early detection of neoplasia that can be detected in DNA purified from plasma or stool of patients with colorectal cancer. The primary purpos...
- Characterization of mutant MUTYH proteins associated with familial colorectal cancer
[作者：Ali, M; Kim, H; Cleary, S; Cupples, C; Gallinger, S; Bristow, R,期刊：Gastroenterology, 页码：499-507 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: The human mutyh gene encodes a base excision repair protein that prevents G:C to T:A transversions in DNA. Biallelic mutations in this gene are associated with recessively inherited familial colorectal...
- Utility of biomarkers in prediction of response to ablative therapy in Barrett's esophagus
[作者：Prasad, GA; Wang, KK; Halling, KC; Buttar, NS; Wongkeesong, LM; Zinsmeister, AR; Brankley, SM; Fritcher, EGB; Westra, WM; Krishnadath, KK; Lutzke, LS; Borkenhagen, LS,期刊：Gastroenterology, 页码：370-379 , 文章类型： Article，,卷期：2008年135-2]
- Background & Aims: Photodynamic therapy (PDT) has been shown to be effective in the treatment of high-grade dysplasia (HGD)/mucosal carcinoma in Barrett's esophagus (BE). Substantial proportions of patients do not respon...
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