- Location, Location, Location: FoxM1 Mediates beta-Catenin Nuclear Translocation and Promotes Glioma Tumorigenesis
[作者：Bowman, A; Nusse, R,期刊：Cancer Cell, 页码：415-416 , 文章类型： Editorial Material，,卷期：2011年20-4]
- Genetic alterations in the Wnt/beta-catenin/TCF-signaling pathway are commonly found in human tumors, but not in glioblastomas. In this issue of Cancer Cell, Zhang et al. report that FoxM1 mediates beta-catenin nuclear t...
- RAIDDing ER Stress for Oncolytic Viral Therapy
[作者：McConkey, DJ,期刊：Cancer Cell, 页码：416-418 , 文章类型： Editorial Material，,卷期：2011年20-4]
- Oncolytic viruses exploit molecular differences between normal and cancer cells to selectively kill the latter. Results of a synthetic lethal screen described in this issue of Cancer Cell demonstrate that components of t...
- Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2
[作者：Kinch, L; Grishin, NV; Brugarolas, J,期刊：Cancer Cell, 页码：418-420 , 文章类型： Editorial Material，,卷期：2011年20-4]
- Fumarate hydratase (FH) is a tumor suppressor, but how it acts is unclear. Two reports in this issue of Cancer Cell reveal that FH deficiency leads to succination of Keap1, stabilization of Nrf2, and induction of stress-...
- Resistance to EGFR-Targeted Therapy: A Family Affair
[作者：Vlacich, G; Coffey, RJ,期刊：Cancer Cell, 页码：423-425 , 文章类型： Editorial Material，,卷期：2011年20-4]
- The EGFR-directed antibody cetuximab has proven, albeit modest, clinical benefit as monotherapy in head and neck and colorectal cancers. In a recent study, Yonesaka et al. uncovered a new mechanism of cetuximab resistanc...
- FoxM1 Promotes beta-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis
[作者：Zhang, N; Wei, P; Gong, AH; Chiu, WT; Lee, HT; Colman, H; Huang, H; Xue, JF; Liu, MG; Wang, Y; Sawaya, R; Xie, KP; Yung, WKA; Medema, RH; He, X; Huang, SY,期刊：Cancer Cell, 页码：427-442 , 文章类型： Article，,卷期：2011年20-4]
- Wnt/beta-catenin signaling is essential for stem cell regulation and tumorigenesis, but its molecular mechanisms are not fully understood. Here, we report that FoxM1 is a downstream component of Wnt signaling and is crit...
- Virus-Tumor Interactome Screen Reveals ER Stress Response Can Reprogram Resistant Cancers for Oncolytic Virus-Triggered Caspase-2 Cell Death
[作者：Mahoney, DJ; Lefebvre, C; Allan, K; Brun, J; Sanaei, CA; Baird, S; Pearce, N; Gronberg, S; Wilson, B; Prakesh, M; Aman, A; Isaac, M; Mamai, A; Uehling, D; Al-Awar, R; Falls, T; Alain, T; Stojdl, DF,期刊：Cancer Cell, 页码：443-456 , 文章类型： Article，,卷期：2011年20-4]
- To identify therapeutic opportunities for oncolytic viral therapy, we conducted genome-wide RNAi screens to search for host factors that modulate rhabdoviral oncolysis. Our screens uncovered the endoplasmic reticulum (ER...
- Androgen Receptor Gene Expression in Prostate Cancer Is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine-Specific Demethylase 1
[作者：Cai, CM; He, HSHS; Chen, S; Coleman, I; Wang, HY; Fang, Z; Chen, SY; Nelson, PS; Liu, XS; Brown, M; Balk, SP,期刊：Cancer Cell, 页码：457-471 , 文章类型： Article，,卷期：2011年20-4]
- Androgen receptor (AR) is reactivated in castration-resistant prostate cancer (CRPC) through mechanisms including marked increases in AR gene expression. We identify an enhancer in the AR second intron contributing to in...
- A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies
[作者：Schaefer, G; Haber, L; Crocker, LM; Shia, S; Shao, L; Dowbenko, D; Totpal, K; Wong, A; Lee, CV; Stawicki, S; Clark, R; Fields, C; Phillips, GDL; Prell, RA; Danilenko, DM; Franke, Y; Stephan, JP; Hwang, J; Wu, Y; Bostrom, J; Sliwkowski, MX; Fuh, G; Eigenbrot, C,期刊：Cancer Cell, 页码：472-486 , 文章类型： Article，,卷期：2011年20-4]
- Extensive crosstalk among ErbB/HER receptors suggests that blocking signaling from more than one family member may be essential to effectively treat cancer and limit drug resistance. We generated a conventional IgG molec...
- SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity
[作者：Kim, HS; Vassilopoulos, A; Wang, RH; Lahusen, T; Xiao, Z; Xu, XL; Li, CL; Veenstra, TD; Li, B; Yu, HT; Ji, JF; Wang, XW; Park, SH; Cha, YI; Gius, D; Deng, CX,期刊：Cancer Cell, 页码：487-499 , 文章类型： Article，,卷期：2011年20-4]
- Members of sirtuin family regulate multiple critical biological processes, yet their role in carcinogenesis remains controversial. To investigate the physiological functions of SIRT2 in development and tumorigenesis, we ...
- The Metabolic Regulator ERR alpha, a Downstream Target of HER2/IGF-1R, as a Therapeutic Target in Breast Cancer
[作者：Chang, CY; Kazmin, D; Jasper, JS; Kunder, R; Zuercher, WJ; McDonnell, DP,期刊：Cancer Cell, 页码：500-510 , 文章类型： Article，,卷期：2011年20-4]
- A genomic signature designed to assess the activity of the estrogen-related receptor alpha (ERR alpha) was used to profile more than 800 breast tumors, revealing a shorter disease-free survival in patients with tumors ex...
- An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma
[作者：Ooi, A; Wong, JC; Petillo, D; Roossien, D; Perrier-Trudova, V; Whitten, D; Min, BWH; Tan, MH; Zhang, ZF; Yang, XMJ; Zhou, M; Gardie, B; Molinie, V; Richard, S; Tan, PH; Teh, BT; Furge, KA,期刊：Cancer Cell, 页码：511-523 , 文章类型： Article，,卷期：2011年20-4]
- Fumarate hydratase (FH) mutation causes hereditary type 2 papillary renal cell carcinoma (PRCC2). The main effect of FH mutation is fumarate accumulation. The current paradigm posits that the main consequence of fumarate...
- Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
[作者：Adam, J; Hatipoglu, E; O'Flaherty, L; Ternette, N; Sahgal, N; Lockstone, H; Baban, D; Nye, E; Stamp, GW; Wolhuter, K; Stevens, M; Fischer, R; Carmeliet, P; Maxwell, PH; Pugh, CW; Frizzell, N; Soga, T; Kessler, BM; El-Bahrawy, M; Ratcliffe, PJ; Pollard, PJ,期刊：Cancer Cell, 页码：524-537 , 文章类型： Article，,卷期：2011年20-4]
- The Krebs cycle enzyme fumarate hydratase (FH) is a human tumor suppressor whose inactivation is associated with the development of leiomyomata, renal cysts, and tumors. It has been proposed that activation of hypoxia in...
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