- Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma
[作者：Snuderl, M; Fazlollahi, L; Le, LP; Nitta, M; Zhelyazkova, BH; Davidson, CJ; Akhavanfard, S; Cahil, DP; Aldape, KD; Betensky, RA; Louis, DN; Iafrate, AJ,期刊：Cancer Cell, 页码：810-817 , 文章类型： Article，,卷期：2011年20-6]
- Tumor heterogeneity has been implicated in tumor growth and progression as well as resistance to therapy. We present an example of genetic heterogeneity in human malignant brain tumors in which multiple closely related d...
- Metastatic Cells Will Take Any Help They Can Get
[作者：Hynes, RO,期刊：Cancer Cell, 页码：689-690 , 文章类型： Editorial Material，,卷期：2011年20-6]
- Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis. First, monocyte/macrophages expressing alpha ...
- Stable IL-10: A New Therapeutic that Promotes Tumor Immunity
[作者：Teng, MWL; Darcy, PK; Smyth, MJ,期刊：Cancer Cell, 页码：691-693 , 文章类型： Editorial Material，,卷期：2011年20-6]
- In this issue of Cancer Cell, Mumm et al. demonstrate that pegylated IL-10 increases CD8(+) T cell numbers, IFN-gamma secretion, and cytotoxicity in established tumors, enhancing antigen presentation machinery and suppre...
- Ring-Fencing BRCA1 Tumor Suppressor Activity
[作者：Patel, KJ; Crossan, GP; Hodskinson, MRG,期刊：Cancer Cell, 页码：693-695 , 文章类型： Editorial Material，,卷期：2011年20-6]
- BRCA1 is a crucial human breast and ovarian cancer tumor suppressor gene. The article by Drost et al. in this issue of Cancer Cell together with a recent paper in Science now provide a clearer picture of how this large a...
- Many Tumors in One: A Daunting Therapeutic Prospect
[作者：Ene, CI; Fine, HA,期刊：Cancer Cell, 页码：695-697 , 文章类型： Editorial Material，,卷期：2011年20-6]
- In this issue of Cancer Cell, Snuderl and coworkers demonstrate intratumoral genetic heterogeneity in glioblastoma based on in situ amplification of distinct genomic loci within individual cells in a mutually exclusive p...
- Targeting Liver Cancer: First Steps toward a miRacle?
[作者：Schwabe, RF; Wang, TC,期刊：Cancer Cell, 页码：698-699 , 文章类型： Editorial Material，,卷期：2011年20-6]
- In a recent issue of Cell, Iliopoulos and colleagues demonstrate a novel and targetable epigenetic amplification loop in hepatocellular carcinoma involving HNF4 alpha, miR-124, IL6-R, Stat3, miR-24, and miR-629. These re...
- VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging alpha 4 beta 1-Positive Osteoclast Progenitors
[作者：Lu, X; Mu, E; Wei, Y; Riethdorf, S; Yang, QF; Yuan, M; Yan, J; Hua, YL; Tiede, BJ; Lu, XM; Haffty, BG; Pantel, K; Massague, J; Kang, YB,期刊：Cancer Cell, 页码：701-714 , 文章类型： Article，,卷期：2011年20-6]
- Breast cancer patients often develop locoregional or distant recurrence years after mastectomy. Understanding the mechanism of metastatic recurrence after dormancy is crucial for improving the cure rate for breast cancer...
- Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia
[作者：Packer, LM; Rana, S; Hayward, R; O'Hare, T; Eide, CA; Rebocho, A; Heidorn, S; Zabriskie, MS; Niculescu-Duvaz, I; Druker, BJ; Springer, C; Marais, R,期刊：Cancer Cell, 页码：715-727 , 文章类型： Article，,卷期：2011年20-6]
- We show that imatinib, nilotinib, and dasatinib possess weak off-target activity against RAF and, therefore, drive paradoxical activation of BRAF and CRAF in a RAS-dependent manner. Critically, because RAS is activated b...
- Combined Genetic Inactivation of beta 2-Microglobulin and CD58 Reveals Frequent Escape from Immune Recognition in Diffuse Large B Cell Lymphoma
[作者：Challa-Malladi, M; Lieu, YK; Califano, O; Holmes, AB; Bhagat, G; Murty, VV; Dominguez-Sola, D; Pasqualucci, L; Dalla-Favera, R,期刊：Cancer Cell, 页码：728-740 , 文章类型： Article，,卷期：2011年20-6]
- We report that diffuse large B cell lymphoma (DLBCL) commonly fails to express cell-surface molecules necessary for the recognition of tumor cells by immune-effector cells. In 29% of cases, mutations and deletions inacti...
- beta-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas
[作者：Damsky, WE; Curley, DP; Santhanakrishnan, M; Rosenbaum, LE; Platt, JT; Rothberg, BEG; Taketo, MM; Dankort, D; Rimm, DL; McMahon, M; Bosenberg, M,期刊：Cancer Cell, 页码：741-754 , 文章类型： Article，,卷期：2011年20-6]
- Malignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated i...
- Oncogene-Targeting T Cells Reject Large Tumors while Oncogene Inactivation Selects Escape Variants in Mouse Models of Cancer
[作者：Anders, K; Buschow, C; Herrmann, A; Milojkovic, A; Loddenkemper, C; Kammertoens, T; Daniel, P; Yu, H; Charo, J; Blankenstein, T,期刊：Cancer Cell, 页码：755-767 , 文章类型： Article，,卷期：2011年20-6]
- The genetic instability of cancer cells frequently causes drug resistance. We established mouse cancer models, which allowed targeting of an oncogene by drug-mediated inactivation or monospecific CD8(+) effector T (T(E))...
- WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing
[作者：Amin, EM; Oltean, S; Hua, J; Gammons, MVR; Hamdollah-Zadeh, M; Welsh, GI; Cheung, MK; Ni, L; Kase, S; Renne, ES; Symonds, KE; Nowak, DG; Royer-Pokora, B; Saleem, MA; Hagiwara, M; Schumacher, VA; Harper, SJ; Hinton, DR; Bates, DO; Ladomery, MR,期刊：Cancer Cell, 页码：768-780 , 文章类型： Article，,卷期：2011年20-6]
- Angiogenesis is regulated by the balance of proangiogenic VEGF(165) and antiangiogenic VEGF165b splice isoforms. Mutations in WT1, the Wilms' tumor suppressor gene, suppress VEGF(165)b and cause abnormal gonadogenesis, r...
- IL-10 Elicits IFN gamma-Dependent Tumor Immune Surveillance
[作者：Mumm, JB; Emmerich, J; Zhang, XQ; Chan, I; Wu, LL; Mauze, S; Blaisdell, S; Basham, B; Dai, J; Grein, J; Sheppard, C; Hong, K; Cutler, C; Turner, S; LaFace, D; Kleinschek, M; Judo, M; Ayanoglu, G; Langowski, J; Gu, DL; Paporello, B; Murphy, E; Sriram, V; Naravula, S; Desai, B; Medicherla, S; Seghezzi, W; McClanahan, T; Cannon-Carlson, S; Beebe, AM; Oft, M,期刊：Cancer Cell, 页码：781-796 , 文章类型： Article，,卷期：2011年20-6]
- Tumor immune surveillance and cancer immunotherapies are thought to depend on the intratumoral infiltration of activated CD8(+) T cells. Intratumoral CD8(+) T cells are rare and lack activity. IL-10 is thought to contrib...
- BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance
[作者：Drost, R; Bouwman, P; Rottenberg, S; Boon, U; Schut, E; Klarenbeek, S; Klijn, C; van der Heijden, I; van der Gulden, H; Wientjens, E; Pieterse, M; Catteau, A; Green, P; Solomon, E; Morris, JR; Jonkers, J,期刊：Cancer Cell, 页码：797-809 , 文章类型： Article，,卷期：2011年20-6]
- Hereditary breast cancers are frequently caused by germline BRCA1 mutations. The BRCA1(C61G) mutation in the BRCA1 RING domain is a common pathogenic missense variant, which reduces BRCA1/BARD1 heterodimerization and abr...
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