- Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma
[作者：Witt, H; Mack, SC; Ryzhova, M; Bender, S; Sill, M; Isserlin, R; Benner, A; Hielscher, T; Milde, T; Remke, M; Jones, DTW; Northcott, PA; Garzia, L; Bertrand, KC; Wittmann, A; Yao, Y; Roberts, SS; Massimi, L; Van Meter, T; Weiss, WA; Gupta, N; Grajkowska, W; Lach, B; Cho, YJ; von Deimling, A; Kulozik, AE; Witt, O; Bader, GD; Hawkins, CE; Tabori, U; Guha, A; Rutka, JT; Lichter, P; Korshunov, A; Taylor, MD; Pfister, SM,期刊：Cancer Cell, 页码：143-157 , 文章类型： Article，,卷期：2011年20-2]
- Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two ...
- Neuregulin-1-Mediated Autocrine Signaling Underlies Sensitivity to HER2 Kinase Inhibitors in a Subset of Human Cancers
[作者：Wilson, TR; Lee, DY; Berry, L; Shames, DS; Settleman, J,期刊：Cancer Cell, 页码：158-172 , 文章类型： Article，,卷期：2011年20-2]
- HER2 kinase inhibitors, such as lapatinib, have demonstrated clinical efficacy in HER2-amplified breast cancers. By profiling nearly 700 human cancer cell lines, we identified a subset of non-HER2 amplified cancer cells ...
- Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression
[作者：Chen, MH; Pratt, CP; Zeeman, ME; Schultz, N; Taylor, BS; O'Neill, A; Castillo-Martin, M; Nowak, DG; Naguib, A; Grace, DM; Murn, J; Navin, N; Atwal, GS; Sander, C; Gerald, WL; Cordon-Cardo, C; Newton, AC; Carver, BS; Trotman, LC,期刊：Cancer Cell, 页码：173-186 , 文章类型： Article，,卷期：2011年20-2]
- Hyperactivation of the PI 3-kinase/AKT pathway is a driving force of many cancers. Here we identify the AKT-inactivating phosphatase PHLPP1 as a prostate tumor suppressor. We show that Phlpp1-loss causes neoplasia and, o...
- Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer
[作者：Cao, Q; Mani, RS; Ateeq, B; Dhanasekaran, SM; Asangani, IA; Prensner, JR; Kim, JH; Brenner, JC; Jing, XJ; Cao, XH; Wang, R; Li, Y; Dahiya, A; Wang, L; Pandhi, M; Lonigro, RJ; Wu, YM; Tomlins, SA; Palanisamy, N; Qin, ZH; Yu, JD; Maher, CA; Varambally, S; Chinnaiyan, AM,期刊：Cancer Cell, 页码：187-199 , 文章类型： Article，,卷期：2011年20-2]
- Polycomb Repressive Complexes (PRC1 and PRC2)-mediated epigenetic regulation is critical for maintaining cellular homeostasis. Members of Polycomb Group (PcG) proteins including EZH2, a PRC2 component, are upregulated in...
- Dominantly Inherited Constitutional Epigenetic Silencing of MLH1 in a Cancer-Affected Family Is Linked to a Single Nucleotide Variant within the 5 ' UTR
[作者：Hitchins, MP; Rapkins, RW; Kwok, CT; Srivastava, S; Wong, JJL; Khachigian, LM; Polly, P; Goldblatt, J; Ward, RL,期刊：Cancer Cell, 页码：200-213 , 文章类型： Article，,卷期：2011年20-2]
- Constitutional epimutations of tumor suppressor genes manifest as promoter methylation and transcriptional silencing of a single allele in normal somatic tissues, thereby predisposing to cancer. Constitutional MLH1 epimu...
- A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression
[作者：Yuan, WC; Lee, YR; Huang, SF; Lin, YM; Chen, TY; Chung, HC; Tsai, CH; Chen, HY; Chiang, CT; Lai, CK; Lu, LT; Chen, CH; Gu, DL; Pu, YS; Jou, YS; Lu, KP; Hsiao, PW; Shih, HM; Chen, RH,期刊：Cancer Cell, 页码：214-228 , 文章类型： Article，,卷期：2011年20-2]
- Tumor hypoxia is associated with disease progression and treatment failure, but the hypoxia signaling mechanism is not fully understood. Here, we show that KLHL20, a Cullin3 (Cul3) substrate adaptor induced by HIF-1, coo...
- ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma
[作者：Sanz-Moreno, V; Gaggioli, C; Yeo, M; Albrengues, J; Wallberg, F; Viros, A; Hooper, S; Mitter, R; Feral, CC; Cook, M; Larkin, J; Marais, R; Meneguzzi, G; Sahai, E; Marshall, CJ,期刊：Cancer Cell, 页码：229-245 , 文章类型： Article，,卷期：2011年20-2]
- Proinflammatory cytokines are frequently observed in the tumor microenvironment, and chronic inflammation is involved in cancer initiation and progression. We show that cytokine signaling through the receptor subunit GP1...
- Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia
[作者：Kikushige, Y; Ishikawa, F; Miyamoto, T; Shima, T; Urata, S; Yoshimoto, G; Mori, Y; Iino, T; Yamauchi, T; Eto, T; Niiro, H; Iwasaki, H; Takenaka, K; Akashi, K,期刊：Cancer Cell, 页码：246-259 , 文章类型： Article，,卷期：2011年20-2]
- We report here that in chronic lynnphocytic leukemia (CLL), the propensity to generate clonal B cells has been acquired already at the hematopoietic stem cell (HSC) stage. HSCs purified from patients with CLL displayed l...
- Coexpression of Normally Incompatible Developmental Pathways in Retinoblastoma Genesis
[作者：McEvoy, J; Flores-Otero, J; Zhang, JK; Nemeth, K; Brennan, R; Bradley, C; Krafcik, F; Rodriguez-Galindo, C; Wilson, M; Xiong, SB; Lozano, G; Sage, J; Fu, L; Louhibi, L; Trimarchi, J; Pani, A; Smeyne, R; Johnson, D; Dyer, MA,期刊：Cancer Cell, 页码：260-275 , 文章类型： Article，,卷期：2011年20-2]
- It is widely believed that the molecular and cellular features of a tumor reflect its cell of origin and can thus provide clues about treatment targets. The retinoblastoma cell of origin has been debated for over a centu...
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