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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共41条记录   Mechanisms of glomerulosclerosis in diabetic nephropathy [作者：Qian, Y; Feldman, E; Pennathur, S; Kretzler, M; Brosius, FC,期刊：Diabetes, 页码：1439-1445 , 文章类型： Article，,卷期：2008年57-6] Reduced glucocorticoid production rate, decreased 5 alpha-reductase activity, and adipose tissue insulin sensitization after weight loss [作者：Tomlinson, JW; Finney, J; Hughes, BA; Hughes, SV; Stewart, PM,期刊：Diabetes, 页码：1536-1543 , 文章类型： Article，,卷期：2008年57-6] OBJECTIVE-The epidemics of obesity, insulin resistance, and type 2 diabetes have heightened the need to understand mechanisms that contribute to their pathogenesis. Increased endogenous glucocorticoid production has been... Transgenic mice overexpressing neuropeptide Y in noradrenergic neurons - A novel model of increased adiposity and impaired glucose tolerance [作者：Ruohonen, ST; Pesonen, U; Moritz, N; Kaipio, K; Roytta, M; Koulu, M; Savontaus, E,期刊：Diabetes, 页码：1517-1525 , 文章类型： Article，,卷期：2008年57-6] OBJECTIVE-A functional polymorphism leucine 7 proline in the human neuropeptide Y (NPY) gene leading to increased NPY release from sympathetic nerves is associated with traits of metabolic syndrome. Although hypothala... Oxidative stress as a major culprit in kidney disease in diabetes [作者：Forbes, JM; Coughlan, MT; Cooper, ME,期刊：Diabetes, 页码：1446-1454 , 文章类型： Article，,卷期：2008年57-6] It is postulated that localized tissue oxidative stress is a key component in the development of diabetic nephropathy. There remains controversy, however, as to whether this is an early link between hyperglycemia and ren... Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance [作者：Li, M; Kim, DH; Tsenovoy, PL; Peterson, SJ; Rezzani, R; Rodella, LF; Aronow, WS; Ikehara, S; Abraham, NG,期刊：Diabetes, 页码：1526-1535 , 文章类型： Article，,卷期：2008年57-6] OBJECTIVE-We hypothesized that the induction of heme oxygenase (HO)-1 and increased HO activity, which induces arterial antioxidative enzymes and vasoprotection in a mouse and a rat model of diabetes, would ameliorate in... Interaction of oral antidiabetic drugs with hepatic uptake transporters - Focus on organic anion transporting polypeptides and organic cation transporter 1 [作者：Bachmakov, L; Glaeser, H; Fromm, MF; Konig, J,期刊：Diabetes, 页码：1463-1469 , 文章类型： Article，,卷期：2008年57-6] OBJECTIVE-The uptake of drugs into hepatocytes is a key determinant for hepatic metabolism, intrahepatic action, their subsequent systemic plasma concentrations, and extrahepatic actions. In vitro and in vivo studies ind... A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes [作者：Phillips, B; Nylander, K; Harnaha, J; Machen, J; Lakomy, R; Styche, A; Gillis, K; Brown, L; Lafreniere, D; Gallo, M; Knox, J; Hogeland, K; Trucco, M; Giannoukakis, N,期刊：Diabetes, 页码：1544-1555 , 文章类型： Article，,卷期：2008年57-6] OBJECTIVE-This study was aimed at ascertaining the efficacy of antisense oligonucleotide-formulated microspheres to prevent type 1 diabetes and to reverse new-onset disease.RESEARCH DESIGN AND METHODS-Microspheres carryi... Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice [作者：Cani, PD; Bibiloni, R; Knauf, C; Neyrinck, AM; Neyrinck, AM; Delzenne, NM; Burcelin, R,期刊：Diabetes, 页码：1470-1481 , 文章类型： Article，,卷期：2008年57-6] OBJECTIVE-Diabetes and obesity are characterized by a low-grade inflammation whose molecular origin is unknown. We previously determined, first, that metabolic endotoxemia controls the inflammatory tone, body weight gain... The caspase selective inhibitor EP1013 augments human islet graft function arid longevity in marginal mass islet transplantation in mice [作者：Emamaullee, JA; Davis, J; Pawlick, R; Toso, C; Merani, S; Cai, SX; Tseng, B; Shapiro, AMJ,期刊：Diabetes, 页码：1556-1566 , 文章类型： Article，,卷期：2008年57-6] OBJECTIVE-Clinical islet transplantation can provide insulin independence in patients with type 1 diabetes, but chronic graft failure has been observed. This has been attributed in part to loss of >= 60% of the transplan... Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion [作者：Stafford, JM; Yu, F; Printz, R; Hasty, AH; Swift, LL; Niswender, KD,期刊：Diabetes, 页码：1482-1490 , 文章类型： Article，,卷期：2008年57-6] OBJECTIVE-Elevated triglyceride (TG) is the major plasma lipid abnormality in obese and diabetic patients and contributes to cardiovascular morbidity in these disorders. We sought to identify novel mechanisms leading to ... Kinin B-1 receptor deficiency leads to leptin hypersensitivity and resistance to obesity [作者：Mori, MA; Araujo, RC; Reis, FCG; Sgai, DG; Fonseca, RG; Barros, CC; Merino, VF; Passadore, M; Barbosa, AM; Ferrari, B; Carayon, P; Castro, CHM; Shimuta, SI; Luz, J; Bascands, JL; Schanstra, JP; Even, PC; Oliveira, SM; Bader, M; Pesquero, JB,期刊：Diabetes, 页码：1491-1500 , 文章类型： Article，,卷期：2008年57-6] OBJECTIVE-Kinins mediate pathophysiological processes related to hypertension, pain, and inflammation through the activation of two G-protein-coupled receptors, named B-1 and B-2. Although these peptides have been relate... Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance [作者：Tan, BK; Heutling, D; Chen, J; Farhatullah, S; Adya, R; Keay, SD; Kennedy, CR; Lehnert, H; Randeva, HS,期刊：Diabetes, 页码：1501-1507 , 文章类型： Article，,卷期：2008年57-6] OBJECTIVE-Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. Vaspin (visceral adipose tissue-derived serine protease inhibitor) levels increase with hyperinsulinemia and obesity. Currentl... Malonyl coenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle [作者：Bouzakri, K; Austin, R; Rune, A; Lassman, ME; Garcia-Roves, PM; Berger, JP; Krook, A; Chibalin, AV; Zhang, BB; Zierath, JR,期刊：Diabetes, 页码：1508-1516 , 文章类型： Article，,卷期：2008年57-6] OBJECTIVE-Malonyl coenzyme A (CoA) decarboxylase (MCD) is a key enzyme responsible for malonyl-CoA turnover and functions in the control of the balance between lipid and glucose metabolism. We utilized RNA interference (... Critical roles for macrophages in islet angiogenesis and maintenance during pancreatic degeneration [作者：Tessem, JS; Jensen, JN; Pelli, H; Dai, XM; Zong, XH; Stanley, ER; Jensen, J; DeGregori, J,期刊：Diabetes, 页码：1605-1617 , 文章类型： Article，,卷期：2008年57-6] OBJECTIVE-Chronic pancreatitis, characterized by pancreatic exocrine tissue destruction with initial maintenance of islets, eventually leads to insulin-dependent diabetes in most patients. Mice deficient for the transcri... Voltage-gated ion channels in human pancreatic beta-cells: Electrophysiological characterization and role in insulin secretion [作者：Braun, M; Rantracheya, R; Bengtsson, M; Zhang, Q; Karanauskaite, J; Partridge, C; Johnson, PR; Rorsman, P,期刊：Diabetes, 页码：1618-1628 , 文章类型： Article，,卷期：2008年57-6] OBJECTIVE-To characterize the voltage-gated ion channels in human beta-cells from nondiabetic donors and their role in glucose-stimulated insulin release.RESEARCH DESIGN AND METHODS-Insulin release was, measured from int... Suppressors of cytokine-signaling proteins induce insulin resistance in the retina and promote survival of retinal cells [作者：Liu, XB; Mameza, MG; Lee, YS; Eseonu, CI; Yu, CR; Derwent, JJK; Egwuagu, CE,期刊：Diabetes, 页码：1651-1658 , 文章类型： Article，,卷期：2008年57-6] OBJECTIVE-Suppressors of cytokine signaling (SOCS) are implicated in the etiology of diabetes, obesity, and metabolic syndrome. Here, we show that some SOCS members are induced, while others are constitutively expressed,...