- Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta(3)-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes
[作者:Ahmad, F; Lindh, R; Tang, Y; Ruishalme, I; Ost, A; Sahachartsiri, B; Stralfors, P; Degerman, E; Manganiello, VC,期刊:Biochemical Journal, 页码:399-410 , 文章类型: Article,,卷期:2009年424-Part 3]
- In adipocytes, PDE3B (phosphodiesterase 3B) is an important regulatory effector in signalling pathways controlled by insulin and cAMP-increasing hormones. Stimulation of 3T3-L1 adipocytes with insulin or the beta(3)-adre...
- A putrescine-anthracene conjugate: a paradigm for selective drug delivery
[作者:Palmer, AJ; Ghani, RA; Kaur, N; Phanstiel, O; Wallace, HM,期刊:Biochemical Journal, 页码:431-438 , 文章类型: Article,,卷期:2009年424-Part 3]
- Increased polyamine concentrations play an important role in the development of cancer at all stages, from initiation through to maintenance of the transformed phenotype. One way cancer cells accumulate increased concent...
- Threonine at position 306 of the KAT1 potassium channel is essential for channel activity and is a target site for ABA-activated SnRK2/OST1/SnRK2.6 protein kinase
[作者:Sato, A; Sato, Y; Fukao, Y; Fujiwara, M; Umezawa, T; Shinozaki, K; Hibi, T; Taniguchi, M; Miyake, H; Goto, DB; Uozumi, N,期刊:Biochemical Journal, 页码:439-448 , 文章类型: Article,,卷期:2009年424-Part 3]
- The Arabidopsis thaliana K+ channel KAT1 has been suggested to have a key role in mediating the aperture of stomata pores on the surface of plant leaves. Although the activity of KAT1 is thought to be regulated by phosph...
- Mesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathway
[作者:Chang, MC; Chen, CA; Hsieh, CY; Lee, CN; Su, YN; Hu, YH; Cheng, WF,期刊:Biochemical Journal, 页码:449-458 , 文章类型: Article,,卷期:2009年424-Part 3]
- Mesothelin, a secreted protein, is overexpressed in some cancers, but its exact function remains unclear. The aim of the present Study was to evaluate the possible function of mesothelin. Real-time PCR, RT (reverse trans...
- Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets
[作者:Casimir, M; Rubi, B; Frigerio, F; Chaffard, G; Maechler, P,期刊:Biochemical Journal, 页码:459-466 , 文章类型: Article,,卷期:2009年424-Part 3]
- Transfer of reducing equivalents between cytosolic compartments and the mitochondrial matrix is mediated by NADH shuttles. Among these, the malate-aspartate shuttle has been proposed to play a major role in beta-cells fo...
- Nucleic-acid-binding properties of the C2-L1Tc nucleic acid chaperone encoded by L1Tc retrotransposon
[作者:Heras, SR; Thomas, MC; Macias, F; Patarroyo, ME; Alonso, C; Lopez, MC,期刊:Biochemical Journal, 页码:479-490 , 文章类型: Article,,卷期:2009年424-Part 3]
- It has been reported previously that the C2-L1Tc protein located in the Trypanosoma cruzi LINE (long interspersed nuclear element) L1Tc 3' terminal end has NAC (nucleic acid chaperone) activity, an essential activity for...
- Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-kappa B modulates glucocorticoid receptor and NF-kappa B signalling in HEK-293 cells (vol 422, pg 521, 2009)
[作者:Psarra, AMG; Hermann, S; Panayotou, G; Spyrou, G,期刊:Biochemical Journal, 页码:501-501 , 文章类型: Correction,,卷期:2009年424-Part 3]
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- Calling International Rescue: knowledge lost in literature and data landslide!
[作者:Attwood, TK; Kell, DB; McDermott, P; Marsh, J; Pettifer, SR; Thorne, D,期刊:Biochemical Journal, 页码:317-333 , 文章类型: Review,,卷期:2009年424-Part 3]
- We live in interesting times. Portents of impending catastrophe pervade the literature, calling us to action in the face of unmanageable volumes of scientific data. But it isn't so much data generation per se, but the sy...
- A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis
[作者:Walters, J; Pop, C; Scott, FL; Drag, M; Swartz, P; Mattos, C; Salvesen, GS; Clark, AC,期刊:Biochemical Journal, 页码:335-345 , 文章类型: Article,,卷期:2009年424-Part 3]
- The caspase-3 zymogen has essentially zero activity until it is cleaved by initiator caspases during apoptosis. However, a mutation of V266E in the dimer interface activates the protease in the absence of chain cleavage....
- Mechanistic insights into Cu(I) cluster transfer between the chaperone CopZ and its cognate Cu(I)-transporting P-type ATPase, CopA
[作者:Singleton, C; Hearnshaw, S; Zhou, L; Le Brun, NE; Hemmings, AM,期刊:Biochemical Journal, 页码:347-356 , 文章类型: Article,,卷期:2009年424-Part 3]
- Multinuclear Cu(I) clusters are common in nature, but little is known about their formation or transfer between proteins. CopZ and CopA from Bacillus subtilis, which are involved in a copper-efflux pathway, both readily ...
- Binary and ternary crystal structure analyses of a novel inhibitor with 17 beta-HSD type 1: a lead compound for breast cancer therapy
[作者:Mazumdar, M; Fournier, D; Zhu, DW; Cadot, C; Poirier, D; Lin, SX,期刊:Biochemical Journal, 页码:357-366 , 文章类型: Article,,卷期:2009年424-Part 3]
- Oestradiol is a well-characterized sex hormone that stimulates breast cancer and other oestrogen-related diseases. 17 beta-hydroxysteroid dehydrogenase type 1 (17 beta-HSD1) catalyses the last step in the synthesis of oe...
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