- Recent Advances in Positron Emission Tomography (PET) Radiotracers for Imaging Phosphodiesterases
[作者:Andres, JI; De Angelis, M; Alcazar, J; Celen, S; Bormans, G,期刊:Current Topics in Medicinal Chemistry, 页码:1224-1236 , 文章类型: Review,,卷期:2012年12-11]
- Phosphodiesterases (PDEs) are a family of enzymes that metabolically inactivate the second messengers 3',5'-cyclic adenosine monophosphate (cAMP) and/or 3', 5'-cyclic guanosine monophosphate (cGMP). These two messengers ...
- The IC50 Concept Revisited
[作者:Caldwell, GW; Yan, ZY; Lang, WS; Masucci, JA,期刊:Current Topics in Medicinal Chemistry, 页码:1282-1290 , 文章类型: Review,,卷期:2012年12-11]
- A major strategy used in drug design is the inhibition of enzyme activity. The ability to accurately measure the concentration of the inhibitor which is required to inhibit a given biological or biochemical function by h...
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