- GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors
[作者:Ahmed, K; Tunaru, S; Offermanns, S,期刊:Trends in Pharmacological Sciences, 页码:557-562 , 文章类型: Review,,卷期:2009年30-11]
- G-protein-coupled receptors (GPCRs) are the most versatile receptor family as they have the ability to respond to chemically diverse ligands. Despite intensive efforts during the past two decades, there are still more th...
- The "Toll" of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia
[作者:Watkins, LR; Hutchinson, MR; Rice, KC; Maier, SF,期刊:Trends in Pharmacological Sciences, 页码:581-591 , 文章类型: Review,,卷期:2009年30-11]
- Glial activation participates in the mediation of pain including neuropathic pain, due to release of neuroexcitatory, proinflammatory products. Glial activation is now known to occur in response to opioids as well. Opioi...
- Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease?
[作者:Yazbeck, R; Howarth, GS; Abbott, CA,期刊:Trends in Pharmacological Sciences, 页码:600-607 , 文章类型: Review,,卷期:2009年30-11]
- Dipeptidyl peptidase (DPP)-4 is a member of the S9b serine protease family, which also includes DPP8 and DPP9. DPP4 cleaves a number of regulatory factors, including chemokines and growth factors. DPP4 inhibitors have re...
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