- Toll-like receptors as therapeutic targets in gastrointestinal diseases
[作者:Pimentel-Nunes, P; Soares, JB; Roncon-Albuquerque, R; Dinis-Ribeiro, M; Leite-Moreira, AF,期刊:Expert Opinion on Therapeutic Targets, 页码:347-368 , 文章类型: Review,,卷期:2010年14-4]
- Importance of the field: Toll-like receptors (TLRs) are innate immunity receptors that recognize several different antigens, initiating immunological/inflammatory responses. Recent evidence associates numerous pathophysi...
- Targeting mitochondrial dysfunction in neurodegenerative disease: Part I
[作者:Burchell, VS; Gandhi, S; Deas, E; Wood, NW; Abramov, AY; Plun-Favreau, H,期刊:Expert Opinion on Therapeutic Targets, 页码:369-385 , 文章类型: Review,,卷期:2010年14-4]
- Importance of the field: The socioeconomic burden of an aging population has accelerated the urgency of novel therapeutic strategies for neurodegenerative disease. One possible approach is to target mitochondrial dysfunc...
- The endocannabinoid system as a target for the treatment of neuronal damage
[作者:Fernandez-Ruiz, J; Garcia, C; Sagredo, O; Gomez-Ruiz, M; de Lago, E,期刊:Expert Opinion on Therapeutic Targets, 页码:387-404 , 文章类型: Review,,卷期:2010年14-4]
- Importance of the field: Cannabinoids have been proposed as clinically promising neuroprotective molecules, based on their capability to normalize glutamate homeostasis, reducing excitotoxicity, to inhibit calcium influx...
- Targeting orphan nuclear receptor SHP in the treatment of metabolic diseases
[作者:Kim, MK; Chanda, D; Lee, IK; Choi, HS; Park, KG,期刊:Expert Opinion on Therapeutic Targets, 页码:453-466 , 文章类型: Review,,卷期:2010年14-4]
- Importance of the field: The orphan nuclear receptor small heterodimer partner (SHP; NR0B2) is an atypical nuclear receptor that contains a ligand-binding domain, but lacks the conserved DNA-binding domain. Since its dis...
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